Antimicrobial activity of pomegranate peel extract against various type of microorganism
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | MedNEXT Journal of Medical and Health Sciences |
Texto Completo: | https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/340 |
Resumo: | Background: Multidrug-resistant bacteria pose a significant threat, necessitating the development of new antimicrobial agents. Medicinal plants have been explored for their antimicrobial potential, with pomegranate peel being a rich source of bioactive compounds. Studies in Palestine and elsewhere have highlighted the antimicrobial properties of pomegranate peel extract (PPE) against various pathogens. Objective: It was to evaluate the antimicrobial activity of aqueous, ethanolic and methanolic extract of Pomegranate peel on some species of Gram-positive and Gram-negative pathogenic bacteria and Candida albicans. Methods: Aqueous, ethanolic, and methanolic extracts of pomegranate peel were prepared and tested against Gram-positive and Gram-negative bacteria, including clinical isolates, and Candida albicans. Antimicrobial activity was assessed using well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) methods. Results: PPE exhibited good antibacterial activity against Gram-positive bacteria, including S. aureus and MRSA, with the methanolic extract being the most effective. However, VRSA remained resistant to all extracts. Variable results were observed for Gramnegative bacteria, with P. aeruginosa being the most susceptible P. vulgaris showed sensitivity to the ethanolic extract. Notably, all extract types demonstrated antimicrobial activity against Candida albicans, with the methanolic extract being the most potent. Conclusion: Pomegranate peel extract possesses antimicrobial activity against a range of pathogens, with variations based on the type of extract and the target microorganism. Methanolic PPE, in particular, showed strong activity against Candida albicans. These findings suggest the potential use of PPE as an alternative antimicrobial agent in combating infectious diseases, particularly those caused by Gram-positive bacteria and Candida albicans. |
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Antimicrobial activity of pomegranate peel extract against various type of microorganismPomegranate peel extractAntimicrobial agentAqueous extractEthanol extractMethanol extractCandida albicansGram positive bacteriaGram negative bacteriaBackground: Multidrug-resistant bacteria pose a significant threat, necessitating the development of new antimicrobial agents. Medicinal plants have been explored for their antimicrobial potential, with pomegranate peel being a rich source of bioactive compounds. Studies in Palestine and elsewhere have highlighted the antimicrobial properties of pomegranate peel extract (PPE) against various pathogens. Objective: It was to evaluate the antimicrobial activity of aqueous, ethanolic and methanolic extract of Pomegranate peel on some species of Gram-positive and Gram-negative pathogenic bacteria and Candida albicans. Methods: Aqueous, ethanolic, and methanolic extracts of pomegranate peel were prepared and tested against Gram-positive and Gram-negative bacteria, including clinical isolates, and Candida albicans. Antimicrobial activity was assessed using well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) methods. Results: PPE exhibited good antibacterial activity against Gram-positive bacteria, including S. aureus and MRSA, with the methanolic extract being the most effective. However, VRSA remained resistant to all extracts. Variable results were observed for Gramnegative bacteria, with P. aeruginosa being the most susceptible P. vulgaris showed sensitivity to the ethanolic extract. Notably, all extract types demonstrated antimicrobial activity against Candida albicans, with the methanolic extract being the most potent. Conclusion: Pomegranate peel extract possesses antimicrobial activity against a range of pathogens, with variations based on the type of extract and the target microorganism. Methanolic PPE, in particular, showed strong activity against Candida albicans. These findings suggest the potential use of PPE as an alternative antimicrobial agent in combating infectious diseases, particularly those caused by Gram-positive bacteria and Candida albicans.MetaScience Press2023-12-27info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionArticleapplication/pdfhttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/34010.54448/mdnt23409MedNEXT Journal of Medical and Health Sciences; Vol. 4 No. 4 (2023): MedNEXT - November 2023MedNEXT Journal of Medical and Health Sciences; v. 4 n. 4 (2023): MedNEXT - November 20232763-5678reponame:MedNEXT Journal of Medical and Health Sciencesinstname:Faculdade de Medicina em São José do Rio Preto (Faceres)instacron:FACERESenghttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/340/317Copyright (c) 2023 Mohammad Alnees, Lubna Kharraz, Mahdi Awwad, Duha Najajra, Wafaa Menawi, Nour Dalu, Ghofran Kilani, Rozan Mesad, Haya Othman, Hala Hamayel, Abdalaziz Darwishhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessAlnees, MohammadKharraz, LubnaAwwad, MahdiNajajra, DuhaMenawi, WafaaDalu, NourKilani, GhofranMesad, RozanOthman, HayaHamayel, HalaDarwish, Abdalaziz2023-12-27T15:51:16Zoai:ojs2.mednext.zotarellifilhoscientificworks.com:article/340Revistahttps://mednext.zotarellifilhoscientificworks.com/index.php/mednextPUBhttps://mednext.zotarellifilhoscientificworks.com/index.php/mednext/oaimednextjmhs@zotarellifilhoscientificworks.com2763-56782763-5678opendoar:2023-12-27T15:51:16MedNEXT Journal of Medical and Health Sciences - Faculdade de Medicina em São José do Rio Preto (Faceres)false |
dc.title.none.fl_str_mv |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
title |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
spellingShingle |
Antimicrobial activity of pomegranate peel extract against various type of microorganism Alnees, Mohammad Pomegranate peel extract Antimicrobial agent Aqueous extract Ethanol extract Methanol extract Candida albicans Gram positive bacteria Gram negative bacteria |
title_short |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
title_full |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
title_fullStr |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
title_full_unstemmed |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
title_sort |
Antimicrobial activity of pomegranate peel extract against various type of microorganism |
author |
Alnees, Mohammad |
author_facet |
Alnees, Mohammad Kharraz, Lubna Awwad, Mahdi Najajra, Duha Menawi, Wafaa Dalu, Nour Kilani, Ghofran Mesad, Rozan Othman, Haya Hamayel, Hala Darwish, Abdalaziz |
author_role |
author |
author2 |
Kharraz, Lubna Awwad, Mahdi Najajra, Duha Menawi, Wafaa Dalu, Nour Kilani, Ghofran Mesad, Rozan Othman, Haya Hamayel, Hala Darwish, Abdalaziz |
author2_role |
author author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Alnees, Mohammad Kharraz, Lubna Awwad, Mahdi Najajra, Duha Menawi, Wafaa Dalu, Nour Kilani, Ghofran Mesad, Rozan Othman, Haya Hamayel, Hala Darwish, Abdalaziz |
dc.subject.por.fl_str_mv |
Pomegranate peel extract Antimicrobial agent Aqueous extract Ethanol extract Methanol extract Candida albicans Gram positive bacteria Gram negative bacteria |
topic |
Pomegranate peel extract Antimicrobial agent Aqueous extract Ethanol extract Methanol extract Candida albicans Gram positive bacteria Gram negative bacteria |
description |
Background: Multidrug-resistant bacteria pose a significant threat, necessitating the development of new antimicrobial agents. Medicinal plants have been explored for their antimicrobial potential, with pomegranate peel being a rich source of bioactive compounds. Studies in Palestine and elsewhere have highlighted the antimicrobial properties of pomegranate peel extract (PPE) against various pathogens. Objective: It was to evaluate the antimicrobial activity of aqueous, ethanolic and methanolic extract of Pomegranate peel on some species of Gram-positive and Gram-negative pathogenic bacteria and Candida albicans. Methods: Aqueous, ethanolic, and methanolic extracts of pomegranate peel were prepared and tested against Gram-positive and Gram-negative bacteria, including clinical isolates, and Candida albicans. Antimicrobial activity was assessed using well diffusion, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) methods. Results: PPE exhibited good antibacterial activity against Gram-positive bacteria, including S. aureus and MRSA, with the methanolic extract being the most effective. However, VRSA remained resistant to all extracts. Variable results were observed for Gramnegative bacteria, with P. aeruginosa being the most susceptible P. vulgaris showed sensitivity to the ethanolic extract. Notably, all extract types demonstrated antimicrobial activity against Candida albicans, with the methanolic extract being the most potent. Conclusion: Pomegranate peel extract possesses antimicrobial activity against a range of pathogens, with variations based on the type of extract and the target microorganism. Methanolic PPE, in particular, showed strong activity against Candida albicans. These findings suggest the potential use of PPE as an alternative antimicrobial agent in combating infectious diseases, particularly those caused by Gram-positive bacteria and Candida albicans. |
publishDate |
2023 |
dc.date.none.fl_str_mv |
2023-12-27 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion Article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/340 10.54448/mdnt23409 |
url |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/340 |
identifier_str_mv |
10.54448/mdnt23409 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://mednext.zotarellifilhoscientificworks.com/index.php/mednext/article/view/340/317 |
dc.rights.driver.fl_str_mv |
https://creativecommons.org/licenses/by/4.0 info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/4.0 |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
MetaScience Press |
publisher.none.fl_str_mv |
MetaScience Press |
dc.source.none.fl_str_mv |
MedNEXT Journal of Medical and Health Sciences; Vol. 4 No. 4 (2023): MedNEXT - November 2023 MedNEXT Journal of Medical and Health Sciences; v. 4 n. 4 (2023): MedNEXT - November 2023 2763-5678 reponame:MedNEXT Journal of Medical and Health Sciences instname:Faculdade de Medicina em São José do Rio Preto (Faceres) instacron:FACERES |
instname_str |
Faculdade de Medicina em São José do Rio Preto (Faceres) |
instacron_str |
FACERES |
institution |
FACERES |
reponame_str |
MedNEXT Journal of Medical and Health Sciences |
collection |
MedNEXT Journal of Medical and Health Sciences |
repository.name.fl_str_mv |
MedNEXT Journal of Medical and Health Sciences - Faculdade de Medicina em São José do Rio Preto (Faceres) |
repository.mail.fl_str_mv |
mednextjmhs@zotarellifilhoscientificworks.com |
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1796798218329128960 |