Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials
Autor(a) principal: | |
---|---|
Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167 |
Resumo: | The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron. |
id |
FIOCRUZ-5_2222074365479ecc58441495cd334aeb |
---|---|
oai_identifier_str |
oai:ojs.teste-cadernos.ensp.fiocruz.br:article/4167 |
network_acronym_str |
FIOCRUZ-5 |
network_name_str |
Cadernos de Saúde Pública |
repository_id_str |
|
spelling |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trialsAnemiaIron DeficiencyFerrous SulfatePregnant WomenThe objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron.O objetivo deste estudo foi analisar a adesão e os efeitos colaterais de três esquemas de suplementação com sulfato ferroso em gestantes anêmicas. O ensaio clínico incluiu 150 mulheres entre a 16ª e 20ª semanas de gestação, de baixo risco obstétrico e com concentração de hemoglobina entre 8,0 e 11,0g/dL. A intervenção foi realizada com 60mg de ferro elementar, durante 16 (±1) semanas, em três esquemas: uma drágea semanal (n = 48); uma drágea duas vezes por semana (n = 53) ou uma drágea diariamente (n = 49). Os desfechos foram adesão, verificada por entrevista e contagem das drágeas, e efeitos colaterais auto-relatados pelas pacientes. A adesão apresentou tendência declinante (92%, 83% e 71%; p = 0,010) e os efeitos colaterais, ascendente (40%, 45% e 71%; p = 0,002) com o aumento da dose prescrita. Diarréia e dor epigástrica estiveram significativamente associadas à dose administrada (p = 0,002). Os resultados sugerem que em gestantes anêmicas as queixas e a adesão ao tratamento com sulfato ferroso são, respectivamente, direta e inversamente proporcionais à quantidade do ferro medicamentoso.Reports in Public HealthCadernos de Saúde Pública2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlapplication/pdfhttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167Reports in Public Health; Vol. 25 No. 6 (2009): JuneCadernos de Saúde Pública; v. 25 n. 6 (2009): Junho1678-44640102-311Xreponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZenghttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167/8475https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167/8476Souza, Ariani Impieri deBatista Filho, MalaquiasBresani, Cristiane CampelloFerreira, Luiz Oscar CardosoFigueiroa, José Natalinfo:eu-repo/semantics/openAccess2024-03-06T15:28:01Zoai:ojs.teste-cadernos.ensp.fiocruz.br:article/4167Revistahttps://cadernos.ensp.fiocruz.br/ojs/index.php/csphttps://cadernos.ensp.fiocruz.br/ojs/index.php/csp/oaicadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2024-03-06T13:04:48.790485Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)true |
dc.title.none.fl_str_mv |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
spellingShingle |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials Souza, Ariani Impieri de Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
title_short |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_full |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_fullStr |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_full_unstemmed |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_sort |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
author |
Souza, Ariani Impieri de |
author_facet |
Souza, Ariani Impieri de Batista Filho, Malaquias Bresani, Cristiane Campello Ferreira, Luiz Oscar Cardoso Figueiroa, José Natal |
author_role |
author |
author2 |
Batista Filho, Malaquias Bresani, Cristiane Campello Ferreira, Luiz Oscar Cardoso Figueiroa, José Natal |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Souza, Ariani Impieri de Batista Filho, Malaquias Bresani, Cristiane Campello Ferreira, Luiz Oscar Cardoso Figueiroa, José Natal |
dc.subject.por.fl_str_mv |
Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
topic |
Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
description |
The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167 |
url |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167/8475 https://cadernos.ensp.fiocruz.br/ojs/index.php/csp/article/view/4167/8476 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html application/pdf |
dc.publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
publisher.none.fl_str_mv |
Reports in Public Health Cadernos de Saúde Pública |
dc.source.none.fl_str_mv |
Reports in Public Health; Vol. 25 No. 6 (2009): June Cadernos de Saúde Pública; v. 25 n. 6 (2009): Junho 1678-4464 0102-311X reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1798943366389432320 |