Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Cadernos de Saúde Pública |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2009000600005 |
Resumo: | The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron. |
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Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trialsAnemiaIron DeficiencyFerrous SulfatePregnant WomenThe objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz2009-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2009000600005Cadernos de Saúde Pública v.25 n.6 2009reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X2009000600005info:eu-repo/semantics/openAccessSouza,Ariani Impieri deBatista Filho,MalaquiasBresani,Cristiane CampelloFerreira,Luiz Oscar CardosoFigueiroa,José Nataleng2009-06-02T00:00:00Zoai:scielo:S0102-311X2009000600005Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2009-06-02T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false |
dc.title.none.fl_str_mv |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
spellingShingle |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials Souza,Ariani Impieri de Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
title_short |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_full |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_fullStr |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_full_unstemmed |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
title_sort |
Adherence and side effects of three ferrous sulfate treatment regimens on anemic pregnant women in clinical trials |
author |
Souza,Ariani Impieri de |
author_facet |
Souza,Ariani Impieri de Batista Filho,Malaquias Bresani,Cristiane Campello Ferreira,Luiz Oscar Cardoso Figueiroa,José Natal |
author_role |
author |
author2 |
Batista Filho,Malaquias Bresani,Cristiane Campello Ferreira,Luiz Oscar Cardoso Figueiroa,José Natal |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Souza,Ariani Impieri de Batista Filho,Malaquias Bresani,Cristiane Campello Ferreira,Luiz Oscar Cardoso Figueiroa,José Natal |
dc.subject.por.fl_str_mv |
Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
topic |
Anemia Iron Deficiency Ferrous Sulfate Pregnant Women |
description |
The objective of this study was to analyze adherence and side effects of three iron supplement regimens (ferrous sulfate) on anemic pregnant women. The clinical trial involved 150 women between the 16th and 20th gestational weeks, at low obstetric risk and with hemoglobin concentration of between 8.0 and 11.0g/dL. Treatment was provided by ferrous sulfate with 60mg of elemental iron during 16 (± 1) weeks, in three regimens: single tablet a week (n = 48); single tablet twice a week (n = 53) or single tablet a day (n = 49). The outcomes were adherence, assessed through interviews and by counting tablets, and side effects, according to patient information. The adherence showed a declining trend (92%, 83% and 71%; p = 0.010) and the side effects revealed a growing trend (40%, 45% and 71%; p = 0.002) as the dosage increased. Diarrhea and epigastric pain were significantly associated with the dose administered (p = 0.002). These results suggest that in anemic pregnant women, complaints are directly proportional and the compliance is inversely proportional to the amount of medicinal iron. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-06-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2009000600005 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X2009000600005 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0102-311X2009000600005 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
publisher.none.fl_str_mv |
Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz |
dc.source.none.fl_str_mv |
Cadernos de Saúde Pública v.25 n.6 2009 reponame:Cadernos de Saúde Pública instname:Fundação Oswaldo Cruz (FIOCRUZ) instacron:FIOCRUZ |
instname_str |
Fundação Oswaldo Cruz (FIOCRUZ) |
instacron_str |
FIOCRUZ |
institution |
FIOCRUZ |
reponame_str |
Cadernos de Saúde Pública |
collection |
Cadernos de Saúde Pública |
repository.name.fl_str_mv |
Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ) |
repository.mail.fl_str_mv |
cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br |
_version_ |
1754115729142054912 |