Genetic polymorphism and their contribution to cancer susceptibility

Detalhes bibliográficos
Autor(a) principal: Conforti-Froes,Nívea
Data de Publicação: 1998
Outros Autores: El-Zein,Randa, Au,William
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Cadernos de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002
Resumo: Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.
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spelling Genetic polymorphism and their contribution to cancer susceptibilityPolymorphism/GeneticsNeoplasmMolecular EpidemiologySince the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz1998-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002Cadernos de Saúde Pública v.14 suppl.3 1998reponame:Cadernos de Saúde Públicainstname:Fundação Oswaldo Cruz (FIOCRUZ)instacron:FIOCRUZ10.1590/S0102-311X1998000700002info:eu-repo/semantics/openAccessConforti-Froes,NíveaEl-Zein,RandaAu,Williameng2006-08-30T00:00:00Zoai:scielo:S0102-311X1998000700002Revistahttp://cadernos.ensp.fiocruz.br/csp/https://old.scielo.br/oai/scielo-oai.phpcadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br1678-44640102-311Xopendoar:2006-08-30T00:00Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)false
dc.title.none.fl_str_mv Genetic polymorphism and their contribution to cancer susceptibility
title Genetic polymorphism and their contribution to cancer susceptibility
spellingShingle Genetic polymorphism and their contribution to cancer susceptibility
Conforti-Froes,Nívea
Polymorphism/Genetics
Neoplasm
Molecular Epidemiology
title_short Genetic polymorphism and their contribution to cancer susceptibility
title_full Genetic polymorphism and their contribution to cancer susceptibility
title_fullStr Genetic polymorphism and their contribution to cancer susceptibility
title_full_unstemmed Genetic polymorphism and their contribution to cancer susceptibility
title_sort Genetic polymorphism and their contribution to cancer susceptibility
author Conforti-Froes,Nívea
author_facet Conforti-Froes,Nívea
El-Zein,Randa
Au,William
author_role author
author2 El-Zein,Randa
Au,William
author2_role author
author
dc.contributor.author.fl_str_mv Conforti-Froes,Nívea
El-Zein,Randa
Au,William
dc.subject.por.fl_str_mv Polymorphism/Genetics
Neoplasm
Molecular Epidemiology
topic Polymorphism/Genetics
Neoplasm
Molecular Epidemiology
description Since the majority of chemical carcinogens are not capable of causing hazardous effects per se, the metabolism of these compounds is a crucial part of the initial host response to the environmental exposure. Disturbances in the balance between activation and detoxification may thus explain the individual variations in responses to exposures to carcinogens. The amount of the ultimate carcinogen produced depends on the action of competing activation and detoxification pathways involving cytochrome P450 and glutathione-S-transferases enzymes.
publishDate 1998
dc.date.none.fl_str_mv 1998-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0102-311X1998000700002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0102-311X1998000700002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
publisher.none.fl_str_mv Escola Nacional de Saúde Pública Sergio Arouca, Fundação Oswaldo Cruz
dc.source.none.fl_str_mv Cadernos de Saúde Pública v.14 suppl.3 1998
reponame:Cadernos de Saúde Pública
instname:Fundação Oswaldo Cruz (FIOCRUZ)
instacron:FIOCRUZ
instname_str Fundação Oswaldo Cruz (FIOCRUZ)
instacron_str FIOCRUZ
institution FIOCRUZ
reponame_str Cadernos de Saúde Pública
collection Cadernos de Saúde Pública
repository.name.fl_str_mv Cadernos de Saúde Pública - Fundação Oswaldo Cruz (FIOCRUZ)
repository.mail.fl_str_mv cadernos@ensp.fiocruz.br||cadernos@ensp.fiocruz.br
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