Modern cancer epidemiological research: genetic polymorphisms and environment

Detalhes bibliográficos
Autor(a) principal: Wünsch Filho,Victor
Data de Publicação: 2005
Outros Autores: Zago,Marco A
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista de Saúde Pública
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102005000300023
Resumo: Individual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposures could be relevant for a better understanding of cancer etiology and the mechanisms of carcinogenesis and also for new insights on cancer prognosis. This study reviews the approaches of molecular epidemiology in cancer research, stressing case-control and cohort designs involving genetic polymorphisms, and factors that could introduce bias and confounding in these studies. Similarly to classical epidemiological research, genetic polymorphisms requires considering aspects of precision and accuracy in the study design.
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spelling Modern cancer epidemiological research: genetic polymorphisms and environmentNeoplasms/epidemiologyPolymorphism/geneticsEnvironmental risksEpidemiology, molecularIndividual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposures could be relevant for a better understanding of cancer etiology and the mechanisms of carcinogenesis and also for new insights on cancer prognosis. This study reviews the approaches of molecular epidemiology in cancer research, stressing case-control and cohort designs involving genetic polymorphisms, and factors that could introduce bias and confounding in these studies. Similarly to classical epidemiological research, genetic polymorphisms requires considering aspects of precision and accuracy in the study design.Faculdade de Saúde Pública da Universidade de São Paulo2005-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102005000300023Revista de Saúde Pública v.39 n.3 2005reponame:Revista de Saúde Públicainstname:Universidade de São Paulo (USP)instacron:USP10.1590/S0034-89102005000300023info:eu-repo/semantics/openAccessWünsch Filho,VictorZago,Marco Aeng2005-06-30T00:00:00Zoai:scielo:S0034-89102005000300023Revistahttp://www.scielo.br/scielo.php?script=sci_serial&pid=0034-8910&lng=pt&nrm=isoONGhttps://old.scielo.br/oai/scielo-oai.phprevsp@org.usp.br||revsp1@usp.br1518-87870034-8910opendoar:2005-06-30T00:00Revista de Saúde Pública - Universidade de São Paulo (USP)false
dc.title.none.fl_str_mv Modern cancer epidemiological research: genetic polymorphisms and environment
title Modern cancer epidemiological research: genetic polymorphisms and environment
spellingShingle Modern cancer epidemiological research: genetic polymorphisms and environment
Wünsch Filho,Victor
Neoplasms/epidemiology
Polymorphism/genetics
Environmental risks
Epidemiology, molecular
title_short Modern cancer epidemiological research: genetic polymorphisms and environment
title_full Modern cancer epidemiological research: genetic polymorphisms and environment
title_fullStr Modern cancer epidemiological research: genetic polymorphisms and environment
title_full_unstemmed Modern cancer epidemiological research: genetic polymorphisms and environment
title_sort Modern cancer epidemiological research: genetic polymorphisms and environment
author Wünsch Filho,Victor
author_facet Wünsch Filho,Victor
Zago,Marco A
author_role author
author2 Zago,Marco A
author2_role author
dc.contributor.author.fl_str_mv Wünsch Filho,Victor
Zago,Marco A
dc.subject.por.fl_str_mv Neoplasms/epidemiology
Polymorphism/genetics
Environmental risks
Epidemiology, molecular
topic Neoplasms/epidemiology
Polymorphism/genetics
Environmental risks
Epidemiology, molecular
description Individual cancer susceptibility seems to be related to factors such as changes in oncogenes and tumor suppressor genes expression, and differences in the action of metabolic enzymes and DNA repair regulated by specific genes. Epidemiological studies on genetic polymorphisms of human xenobiotics metabolizing enzymes and cancer have revealed low relative risks. Research considering genetic polymorphisms prevalence jointly with environmental exposures could be relevant for a better understanding of cancer etiology and the mechanisms of carcinogenesis and also for new insights on cancer prognosis. This study reviews the approaches of molecular epidemiology in cancer research, stressing case-control and cohort designs involving genetic polymorphisms, and factors that could introduce bias and confounding in these studies. Similarly to classical epidemiological research, genetic polymorphisms requires considering aspects of precision and accuracy in the study design.
publishDate 2005
dc.date.none.fl_str_mv 2005-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102005000300023
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0034-89102005000300023
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S0034-89102005000300023
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
publisher.none.fl_str_mv Faculdade de Saúde Pública da Universidade de São Paulo
dc.source.none.fl_str_mv Revista de Saúde Pública v.39 n.3 2005
reponame:Revista de Saúde Pública
instname:Universidade de São Paulo (USP)
instacron:USP
instname_str Universidade de São Paulo (USP)
instacron_str USP
institution USP
reponame_str Revista de Saúde Pública
collection Revista de Saúde Pública
repository.name.fl_str_mv Revista de Saúde Pública - Universidade de São Paulo (USP)
repository.mail.fl_str_mv revsp@org.usp.br||revsp1@usp.br
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