Clonality analysis of giant cell lesions of the jaws
Autor(a) principal: | |
---|---|
Data de Publicação: | 2010 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Brazilian Dental Journal |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013 |
Resumo: | Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions. |
id |
FUNORP-1_41f9aead8b1cfa3cadd4b0e08065e337 |
---|---|
oai_identifier_str |
oai:scielo:S0103-64402010000400013 |
network_acronym_str |
FUNORP-1 |
network_name_str |
Brazilian Dental Journal |
repository_id_str |
|
spelling |
Clonality analysis of giant cell lesions of the jawsclonalityclonal naturegiant cell lesiongiant cell granulomaHUMARADespite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions.Fundação Odontológica de Ribeirão Preto2010-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013Brazilian Dental Journal v.21 n.4 2010reponame:Brazilian Dental Journalinstname:Fundação Odontológica de Ribeirão Preto (FUNORP)instacron:FUNORP10.1590/S0103-64402010000400013info:eu-repo/semantics/openAccessAmaral,Fabrício RezendeGomes,Carolina CavaliériOliveira,Carla SilveiraSouza,Paulo Eduardo Alencar deGomez,Ricardo Santiagoeng2010-10-18T00:00:00Zoai:scielo:S0103-64402010000400013Revistahttps://www.scielo.br/j/bdj/https://old.scielo.br/oai/scielo-oai.phpbdj@forp.usp.br||sergio@fosjc.unesp.br1806-47600103-6440opendoar:2010-10-18T00:00Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP)false |
dc.title.none.fl_str_mv |
Clonality analysis of giant cell lesions of the jaws |
title |
Clonality analysis of giant cell lesions of the jaws |
spellingShingle |
Clonality analysis of giant cell lesions of the jaws Amaral,Fabrício Rezende clonality clonal nature giant cell lesion giant cell granuloma HUMARA |
title_short |
Clonality analysis of giant cell lesions of the jaws |
title_full |
Clonality analysis of giant cell lesions of the jaws |
title_fullStr |
Clonality analysis of giant cell lesions of the jaws |
title_full_unstemmed |
Clonality analysis of giant cell lesions of the jaws |
title_sort |
Clonality analysis of giant cell lesions of the jaws |
author |
Amaral,Fabrício Rezende |
author_facet |
Amaral,Fabrício Rezende Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago |
author_role |
author |
author2 |
Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Amaral,Fabrício Rezende Gomes,Carolina Cavaliéri Oliveira,Carla Silveira Souza,Paulo Eduardo Alencar de Gomez,Ricardo Santiago |
dc.subject.por.fl_str_mv |
clonality clonal nature giant cell lesion giant cell granuloma HUMARA |
topic |
clonality clonal nature giant cell lesion giant cell granuloma HUMARA |
description |
Despite the importance of clonality to understand the pathogenesis and progression of tumors, it has not been investigated yet in giant cell lesions of the jaws. The aim of this study was to analyze the clonality of peripheral giant cell lesions (PGCL) and central giant cell lesions (CGCL) of the jaws. Six samples of PGCL and 5 samples of CGCL were analyzed in this study using the polymorphic human androgen receptor locus (HUMARA) assay. Three out of the 5 samples of the CGCL and 3 out of 6 samples of PGCL exhibited a monoclonal pattern. Our findings demonstrate that some giant cell lesions of the jaws are clonal, which indicate that these lesions may have a common genetic mechanism of development. Further studies are necessary to better elucidate the molecular mechanisms involved in the pathogenesis of such lesions. |
publishDate |
2010 |
dc.date.none.fl_str_mv |
2010-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-64402010000400013 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S0103-64402010000400013 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
publisher.none.fl_str_mv |
Fundação Odontológica de Ribeirão Preto |
dc.source.none.fl_str_mv |
Brazilian Dental Journal v.21 n.4 2010 reponame:Brazilian Dental Journal instname:Fundação Odontológica de Ribeirão Preto (FUNORP) instacron:FUNORP |
instname_str |
Fundação Odontológica de Ribeirão Preto (FUNORP) |
instacron_str |
FUNORP |
institution |
FUNORP |
reponame_str |
Brazilian Dental Journal |
collection |
Brazilian Dental Journal |
repository.name.fl_str_mv |
Brazilian Dental Journal - Fundação Odontológica de Ribeirão Preto (FUNORP) |
repository.mail.fl_str_mv |
bdj@forp.usp.br||sergio@fosjc.unesp.br |
_version_ |
1754204091386429440 |