Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone

Detalhes bibliográficos
Autor(a) principal: Baruffi,Marcelo Razera
Data de Publicação: 2002
Outros Autores: Barbieri-Neto,J., Pina-Neto,João Monteiro, Suerzut,C.E., Casartelli,Cacilda
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Genetics and Molecular Biology
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002
Resumo: Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors.
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spelling Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bonebonegiant-cellgranulomatumorchromosomeCytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors.Sociedade Brasileira de Genética2002-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002Genetics and Molecular Biology v.25 n.3 2002reponame:Genetics and Molecular Biologyinstname:Sociedade Brasileira de Genética (SBG)instacron:SBG10.1590/S1415-47572002000300002info:eu-repo/semantics/openAccessBaruffi,Marcelo RazeraBarbieri-Neto,J.Pina-Neto,João MonteiroSuerzut,C.E.Casartelli,Cacildaeng2002-12-06T00:00:00Zoai:scielo:S1415-47572002000300002Revistahttp://www.gmb.org.br/ONGhttps://old.scielo.br/oai/scielo-oai.php||editor@gmb.org.br1678-46851415-4757opendoar:2002-12-06T00:00Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)false
dc.title.none.fl_str_mv Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
title Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
spellingShingle Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
Baruffi,Marcelo Razera
bone
giant-cell
granuloma
tumor
chromosome
title_short Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
title_full Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
title_fullStr Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
title_full_unstemmed Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
title_sort Distinct nonrandom patterns of chromosomal deletions in giant-cell lesions of bone
author Baruffi,Marcelo Razera
author_facet Baruffi,Marcelo Razera
Barbieri-Neto,J.
Pina-Neto,João Monteiro
Suerzut,C.E.
Casartelli,Cacilda
author_role author
author2 Barbieri-Neto,J.
Pina-Neto,João Monteiro
Suerzut,C.E.
Casartelli,Cacilda
author2_role author
author
author
author
dc.contributor.author.fl_str_mv Baruffi,Marcelo Razera
Barbieri-Neto,J.
Pina-Neto,João Monteiro
Suerzut,C.E.
Casartelli,Cacilda
dc.subject.por.fl_str_mv bone
giant-cell
granuloma
tumor
chromosome
topic bone
giant-cell
granuloma
tumor
chromosome
description Cytogenetic analyses were performed on a bone giant cell reparative granuloma (GCRG) and on three bone giant cell tumors (GCT). The present GCRG case is the second to be described cytogenetically. A modal chromosome number of 46 was observed in all samples. Clonal chromosome abnormalities were detected in all cases. The numerical alterations most frequently observed involved the loss of chromosomes 17 and 18. Among the structural anomalies observed, there was preferential involvement of chromosomes 6 and 10. Three GCT cases presented del(10)(p13) and two cases presented del(6)(q25) (1 GCRG and 1 GCT). These breakpoints mapped on 10p and 6q may harbour genes of importance in the development of bone giant cell tumors.
publishDate 2002
dc.date.none.fl_str_mv 2002-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572002000300002
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/S1415-47572002000300002
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Sociedade Brasileira de Genética
publisher.none.fl_str_mv Sociedade Brasileira de Genética
dc.source.none.fl_str_mv Genetics and Molecular Biology v.25 n.3 2002
reponame:Genetics and Molecular Biology
instname:Sociedade Brasileira de Genética (SBG)
instacron:SBG
instname_str Sociedade Brasileira de Genética (SBG)
instacron_str SBG
institution SBG
reponame_str Genetics and Molecular Biology
collection Genetics and Molecular Biology
repository.name.fl_str_mv Genetics and Molecular Biology - Sociedade Brasileira de Genética (SBG)
repository.mail.fl_str_mv ||editor@gmb.org.br
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