Genomic and phylogenetic characterization of brazilian yellow fever virus strains

• Autor(a) principal: Nunes, Márcio Roberto Teixeira
• Data de Publicação: 2012
• Outros Autores: Palacios, Gustavo, Cardoso, Jedson Ferreira, Martins, Lívia Caricio, Sousa Junior, Edivaldo C, Lima, Clayton P. S. de, Medeiros, Daniele Barbosa de Almeida, Savji, Nazir, Desai, Aaloki, Rodrigues, Sueli Guerreiro, Carvalho, Valéria Lima, Lipkin, W. Ian
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/378
• topic: Febre Amarela / transmissão; Vírus da Febre Amarela

Globally, yellow fever virus infects nearly 200,000 people, leading to 30,000 deaths annually. Although the virus is endemic to Latin America, only a single genome from this region has been sequenced. Here, we report 12 Brazilian yellow fever virus completegenomes, their genetic traits, phylogenetic characterization, and phylogeographic dynamics. Variable 3= noncoding region (3=NCR) patterns and specific mutations throughout the open reading frame altered predicted secondary structures. Our findingssuggest that whereas the introduction of yellow fever virus in Brazil led to genotype I-predominant dispersal throughout South and Central Americas, genotype II remained confined to Bolivia, Peru, and the western Brazilian Amazon.