Genetic divergence and dispersal of Yellow Fever Virus, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2004 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Digital do Instituto Evandro Chagas (Patuá) |
Texto Completo: | https://patua.iec.gov.br/handle/iec/3958 |
Resumo: | An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past. |
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Vasconcelos, Pedro Fernando da CostaBryant, Juliet ERosa, Amélia Paes de Andrade Travassos daTesh, Robert BRodrigues, Sueli GuerreiroBarrett, Alan D. T2019-10-09T11:27:11Z2019-10-09T11:27:11Z2004VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004.1080-6040https://patua.iec.gov.br/handle/iec/3958An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past.CNPq (Brazilian Agency for Scientific and Technologic Development, process 302770/02-0) and the National Institutes of Health (grant AI 50175)Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Arbovirus Reference and Research. Belém, PA, Brasil.University of Texas Medical Branch. Galveston, TX, USA.University of Texas Medical Branch. Galveston, TX, USA.University of Texas Medical Branch. Galveston, TX, USA.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. World Health Organization Collaborating Center for Arbovirus Reference and Research. Belém, PA, Brasil.University of Texas Medical Branch. Galveston, TX, USA.engCenters for Disease Control and PreventionGenetic divergence and dispersal of Yellow Fever Virus, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleFebre Amarela / epidemiologiaFebre Amarela / genéticaFebre Amarela / fisiopatologiaVacina contra Febre Amarela / análiseinfo:eu-repo/semantics/openAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECORIGINALGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdfGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdfapplication/pdf357276https://patua.iec.gov.br/bitstreams/972a030f-d3fc-4ceb-b8ca-bc5f10ab68ac/downloadef1c3da819fa3f02ea45e4876c01a157MD51LICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/9632ddcc-1dea-4a56-b72c-875c61cae100/download11832eea31b16df8613079d742d61793MD52TEXTGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.txtGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.txtExtracted texttext/plain34302https://patua.iec.gov.br/bitstreams/cb8e8990-406f-4389-ab76-49009c15fbc7/download7cd982adb178ebd318ec406a2045139fMD55THUMBNAILGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.jpgGenetic divergence and dispersal of Yellow Fever Virus, Brazil.pdf.jpgGenerated Thumbnailimage/jpeg6159https://patua.iec.gov.br/bitstreams/4ccc43a8-a687-40fa-967c-609148b3865f/download233770fd01c3995293be0399b2137542MD56iec/39582022-10-20 21:06:56.143oai:patua.iec.gov.br:iec/3958https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T21:06:56Repositório Digital do Instituto Evandro Chagas (Patuá) - Instituto Evandro Chagas (IEC)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 |
dc.title.pt_BR.fl_str_mv |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
title |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
spellingShingle |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil Vasconcelos, Pedro Fernando da Costa Febre Amarela / epidemiologia Febre Amarela / genética Febre Amarela / fisiopatologia Vacina contra Febre Amarela / análise |
title_short |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
title_full |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
title_fullStr |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
title_full_unstemmed |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
title_sort |
Genetic divergence and dispersal of Yellow Fever Virus, Brazil |
author |
Vasconcelos, Pedro Fernando da Costa |
author_facet |
Vasconcelos, Pedro Fernando da Costa Bryant, Juliet E Rosa, Amélia Paes de Andrade Travassos da Tesh, Robert B Rodrigues, Sueli Guerreiro Barrett, Alan D. T |
author_role |
author |
author2 |
Bryant, Juliet E Rosa, Amélia Paes de Andrade Travassos da Tesh, Robert B Rodrigues, Sueli Guerreiro Barrett, Alan D. T |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Vasconcelos, Pedro Fernando da Costa Bryant, Juliet E Rosa, Amélia Paes de Andrade Travassos da Tesh, Robert B Rodrigues, Sueli Guerreiro Barrett, Alan D. T |
dc.subject.decsPrimary.pt_BR.fl_str_mv |
Febre Amarela / epidemiologia Febre Amarela / genética Febre Amarela / fisiopatologia Vacina contra Febre Amarela / análise |
topic |
Febre Amarela / epidemiologia Febre Amarela / genética Febre Amarela / fisiopatologia Vacina contra Febre Amarela / análise |
description |
An analysis of 79 yellow fever virus(YFV) isolates collected from 1935 to 2001 in Brazil showed a single genotype (South America) circulating in the country, with the exception of a single strain from Rôndonia, wich represented South America genotype II. Brazilian YFV strains have diverged into two clades; an older clade appears to have become extinct and another has become the dominant lineage in recent years. Pairwise nucleotide diversity between strains ranged from 0 per cent to 7.4 per cent, while amino acid divergence ranged from 0 per cent to 4.6 per cent. Phylogenetic analysis indicated traffic of virus variants through large geographic areas and suggested that migration of infected people may be an important mechanism of virus dispersal. Isolation of vaccine virus from a patient with a fatal case suggests that vaccine-related illness may have been misdiagnosed in the past. |
publishDate |
2004 |
dc.date.issued.fl_str_mv |
2004 |
dc.date.accessioned.fl_str_mv |
2019-10-09T11:27:11Z |
dc.date.available.fl_str_mv |
2019-10-09T11:27:11Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004. |
dc.identifier.uri.fl_str_mv |
https://patua.iec.gov.br/handle/iec/3958 |
dc.identifier.issn.-.fl_str_mv |
1080-6040 |
identifier_str_mv |
VASCONCELOS, Pedro Fernando da Costa et al. Genetic divergence and dispersal of Yellow Fever Virus, Brazil. Emerging Infectious Disease, v. 10, n. 9, p. 1578-1584, Sept. 2004. 1080-6040 |
url |
https://patua.iec.gov.br/handle/iec/3958 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Centers for Disease Control and Prevention |
publisher.none.fl_str_mv |
Centers for Disease Control and Prevention |
dc.source.none.fl_str_mv |
reponame:Repositório Digital do Instituto Evandro Chagas (Patuá) instname:Instituto Evandro Chagas (IEC) instacron:IEC |
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Instituto Evandro Chagas (IEC) |
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IEC |
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IEC |
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Repositório Digital do Instituto Evandro Chagas (Patuá) |
collection |
Repositório Digital do Instituto Evandro Chagas (Patuá) |
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clariceneta@iec.gov.br || Biblioteca@iec.gov.br |
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