Yellow fever virus: historical and current issues regarding recent epidemics and vaccination in Brazil

• Autor(a) principal: Ishak, Ricardo
• Data de Publicação: 2019
• Outros Autores: Ishak, Marluísa de Oliveira Guimarães, Vallinoto, Antonio Carlos Rosário, Pinheiro, Francisco de Paula
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
• Texto Completo: https://patua.iec.gov.br/handle/iec/3994
• topic: Febre Amarela; Vacina contra Febre Amarela; Vírus da Febre Amarela / patogenicidade; Prevalência; Monitoramento Epidemiológico

Yellow fever has been recently described in nonurban areas of Brazil despite 80 years of commercial vaccine use. Although the disease does not spread fear in the general population as it did in the past, yellow fever virus continues to cause many cases of severe disease. Persistence of the virus in the host is a new mechanism to be considered in the pathology of the disease. Immunization with a fractional dose of vaccine during emergency situations needs to be evaluated for antibody duration, and new and improved vaccines should be considered.