Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study

Detalhes bibliográficos
Autor(a) principal: Antinarelli, Luciana Maria Ribeiro
Data de Publicação: 2021
Outros Autores: Silva, Márcio Roberto, Guimarães, Ricardo José de Paula Souza e, Terror, Mariana Sequetto, Lima, Patrícia Enham, Ishii, Joelma de Souza Coimbra, Muniz, Patrícia Fabiano, Coimbra, Elaine Soares
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Digital do Instituto Evandro Chagas (Patuá)
Texto Completo: https://patua.iec.gov.br/handle/iec/4430
Resumo: BACKGROUND: Despite high seroprevalence of asymptomatic infection in humans, toxoplasmosis can manifest as a severe systemic disease, as occurs in the congenital infection. Here we evaluate the seroprevalence of Toxoplasma infection among pregnant women in a highly urbanized area of Brazil. METHODS: A robust seroepidemiological study was conducted using laboratory databases of anti-Toxoplasma gondii serological results together with information on age, month/year of diagnosis and place of residence of pregnant women in the public health system of the city of Juiz de Fora, Brazil. RESULTS: Of 5895 pregnant women analysed, 54.7% showed seronegativity and 44.4% showed seropositivity for immunoglobulin G (IgG) antibodies against Toxoplasma gondii. This seropositivity rate increased to 68.3% when only considering participants from rural areas. Multivariate analysis revealed higher odds of being seropositive associated with age (odds ratio [OR] 1.06 [confidence interval {CI} 1.05 to 1.07]) and with living in rural areas (OR 2.96 [CI 1.64 to 5.36]). The spatial distribution of IgG seropositivity indicated a higher prevalence concentrated in rural and peripheral neighbourhoods. CONCLUSIONS: This is the first report to use spatial analysis to show a cluster of Toxoplasma infection in rural and peripheral neighbourhoods of a highly urbanized municipality, which highlights the need for adequate healthcare actions to be implemented for women living in these areas.
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spelling Antinarelli, Luciana Maria RibeiroSilva, Márcio RobertoGuimarães, Ricardo José de Paula Souza eTerror, Mariana SequettoLima, Patrícia EnhamIshii, Joelma de Souza CoimbraMuniz, Patrícia FabianoCoimbra, Elaine Soares2021-08-30T12:46:21Z2021-08-30T12:46:21Z2021ANTINARELLI, Luciana Maria Ribeiro et al. Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 115, n. 8, p. 896-903, Aug. 2021.1878-3503https://patua.iec.gov.br/handle/iec/443010.1093/trstmh/traa153BACKGROUND: Despite high seroprevalence of asymptomatic infection in humans, toxoplasmosis can manifest as a severe systemic disease, as occurs in the congenital infection. Here we evaluate the seroprevalence of Toxoplasma infection among pregnant women in a highly urbanized area of Brazil. METHODS: A robust seroepidemiological study was conducted using laboratory databases of anti-Toxoplasma gondii serological results together with information on age, month/year of diagnosis and place of residence of pregnant women in the public health system of the city of Juiz de Fora, Brazil. RESULTS: Of 5895 pregnant women analysed, 54.7% showed seronegativity and 44.4% showed seropositivity for immunoglobulin G (IgG) antibodies against Toxoplasma gondii. This seropositivity rate increased to 68.3% when only considering participants from rural areas. Multivariate analysis revealed higher odds of being seropositive associated with age (odds ratio [OR] 1.06 [confidence interval {CI} 1.05 to 1.07]) and with living in rural areas (OR 2.96 [CI 1.64 to 5.36]). The spatial distribution of IgG seropositivity indicated a higher prevalence concentrated in rural and peripheral neighbourhoods. CONCLUSIONS: This is the first report to use spatial analysis to show a cluster of Toxoplasma infection in rural and peripheral neighbourhoods of a highly urbanized municipality, which highlights the need for adequate healthcare actions to be implemented for women living in these areas.Universidade Federal de Minas Gerais. Faculdade de Medicina. Programa de Pós-Graduação em Ciências da Saúde: Infectologia e Medicina Tropical. Belo Horizonte, MG, Brazil / Laboratório Central da Prefeitura de Juiz de Fora. Juiz de Fora, MG, Brazil.Embrapa Gado de Leite. Juiz de Fora, MG, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Geoprocessamento. Ananindeua, PA, Brasil.Universidade Federal de Juiz de Fora. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil.Laboratório Central da Prefeitura de Juiz de Fora. Juiz de Fora, MG, Brazil.Laboratório Central da Prefeitura de Juiz de Fora. Juiz de Fora, MG, Brazil.Laboratório Central da Prefeitura de Juiz de Fora. Juiz de Fora, MG, Brazil.Universidade Federal de Juiz de Fora. Departamento de Parasitologia, Microbiologia e Imunologia. Juiz de Fora, MG, Brazil.engOxford University PressRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional studyinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleToxoplasmose Congênita / patologiaToxoplasmose Congênita / transmissãoGestantesEstudos SoroepidemiológicosZona Ruralinfo:eu-repo/semantics/embargoedAccessreponame:Repositório Digital do Instituto Evandro Chagas (Patuá)instname:Instituto Evandro Chagas (IEC)instacron:IECLICENSElicense.txtlicense.txttext/plain; charset=utf-82182https://patua.iec.gov.br/bitstreams/4cabd432-5fcd-4e9c-a79f-266ff871a8a0/download11832eea31b16df8613079d742d61793MD52ORIGINALRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdfRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdfapplication/pdf551083https://patua.iec.gov.br/bitstreams/1b296910-ab9b-45ad-9a74-949fe4e9c0e6/downloadc9a9c128e29cac82a5d7fdf3f4e6da73MD51TEXTRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdf.txtRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdf.txtExtracted texttext/plain2https://patua.iec.gov.br/bitstreams/4d305343-bd2b-402d-ae63-53b613a4eab6/downloade1c06d85ae7b8b032bef47e42e4c08f9MD55THUMBNAILRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdf.jpgRural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study.pdf.jpgGenerated Thumbnailimage/jpeg3095https://patua.iec.gov.br/bitstreams/b71a034c-493d-4d26-a7f3-e544c2dceaa8/download71859d578212107f7f8c49a4ce09d9eeMD56iec/44302022-10-20 22:19:46.34oai:patua.iec.gov.br:iec/4430https://patua.iec.gov.brRepositório InstitucionalPUBhttps://patua.iec.gov.br/oai/requestclariceneta@iec.gov.br || Biblioteca@iec.gov.bropendoar:2022-10-20T22:19:46Repositório Digital do Instituto Evandro Chagas (Patuá) - 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dc.title.pt_BR.fl_str_mv Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
title Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
spellingShingle Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
Antinarelli, Luciana Maria Ribeiro
Toxoplasmose Congênita / patologia
Toxoplasmose Congênita / transmissão
Gestantes
Estudos Soroepidemiológicos
Zona Rural
title_short Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
title_full Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
title_fullStr Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
title_full_unstemmed Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
title_sort Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study
author Antinarelli, Luciana Maria Ribeiro
author_facet Antinarelli, Luciana Maria Ribeiro
Silva, Márcio Roberto
Guimarães, Ricardo José de Paula Souza e
Terror, Mariana Sequetto
Lima, Patrícia Enham
Ishii, Joelma de Souza Coimbra
Muniz, Patrícia Fabiano
Coimbra, Elaine Soares
author_role author
author2 Silva, Márcio Roberto
Guimarães, Ricardo José de Paula Souza e
Terror, Mariana Sequetto
Lima, Patrícia Enham
Ishii, Joelma de Souza Coimbra
Muniz, Patrícia Fabiano
Coimbra, Elaine Soares
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Antinarelli, Luciana Maria Ribeiro
Silva, Márcio Roberto
Guimarães, Ricardo José de Paula Souza e
Terror, Mariana Sequetto
Lima, Patrícia Enham
Ishii, Joelma de Souza Coimbra
Muniz, Patrícia Fabiano
Coimbra, Elaine Soares
dc.subject.decsPrimary.pt_BR.fl_str_mv Toxoplasmose Congênita / patologia
Toxoplasmose Congênita / transmissão
Gestantes
Estudos Soroepidemiológicos
Zona Rural
topic Toxoplasmose Congênita / patologia
Toxoplasmose Congênita / transmissão
Gestantes
Estudos Soroepidemiológicos
Zona Rural
description BACKGROUND: Despite high seroprevalence of asymptomatic infection in humans, toxoplasmosis can manifest as a severe systemic disease, as occurs in the congenital infection. Here we evaluate the seroprevalence of Toxoplasma infection among pregnant women in a highly urbanized area of Brazil. METHODS: A robust seroepidemiological study was conducted using laboratory databases of anti-Toxoplasma gondii serological results together with information on age, month/year of diagnosis and place of residence of pregnant women in the public health system of the city of Juiz de Fora, Brazil. RESULTS: Of 5895 pregnant women analysed, 54.7% showed seronegativity and 44.4% showed seropositivity for immunoglobulin G (IgG) antibodies against Toxoplasma gondii. This seropositivity rate increased to 68.3% when only considering participants from rural areas. Multivariate analysis revealed higher odds of being seropositive associated with age (odds ratio [OR] 1.06 [confidence interval {CI} 1.05 to 1.07]) and with living in rural areas (OR 2.96 [CI 1.64 to 5.36]). The spatial distribution of IgG seropositivity indicated a higher prevalence concentrated in rural and peripheral neighbourhoods. CONCLUSIONS: This is the first report to use spatial analysis to show a cluster of Toxoplasma infection in rural and peripheral neighbourhoods of a highly urbanized municipality, which highlights the need for adequate healthcare actions to be implemented for women living in these areas.
publishDate 2021
dc.date.accessioned.fl_str_mv 2021-08-30T12:46:21Z
dc.date.available.fl_str_mv 2021-08-30T12:46:21Z
dc.date.issued.fl_str_mv 2021
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv ANTINARELLI, Luciana Maria Ribeiro et al. Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 115, n. 8, p. 896-903, Aug. 2021.
dc.identifier.uri.fl_str_mv https://patua.iec.gov.br/handle/iec/4430
dc.identifier.issn.-.fl_str_mv 1878-3503
dc.identifier.doi.-.fl_str_mv 10.1093/trstmh/traa153
identifier_str_mv ANTINARELLI, Luciana Maria Ribeiro et al. Rural residence remains a risk factor for Toxoplasma infection among pregnant women in a highly urbanized Brazilian area: a robust cross-sectional study. Transactions of the Royal Society of Tropical Medicine and Hygiene, v. 115, n. 8, p. 896-903, Aug. 2021.
1878-3503
10.1093/trstmh/traa153
url https://patua.iec.gov.br/handle/iec/4430
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