Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista do Instituto de Medicina Tropical de São Paulo |
Texto Completo: | https://www.revistas.usp.br/rimtsp/article/view/173923 |
Resumo: | The present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: “Chagas disease”, “benznidazole”, “Drug Therapy”, “Pharmacokinetics”, “Dose-response relationship, drug” and “Chronic disease”. The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease. |
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Ideal benznidazole dose regimen in chronic chagasic patients: a systematic reviewBenznidazoleChagas diseaseDrug therapyChronic phaseThe present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: “Chagas disease”, “benznidazole”, “Drug Therapy”, “Pharmacokinetics”, “Dose-response relationship, drug” and “Chronic disease”. The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease.Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo2020-08-21info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/xmlhttps://www.revistas.usp.br/rimtsp/article/view/17392310.1590/s1678-9946202062052Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e521678-99460036-4665reponame:Revista do Instituto de Medicina Tropical de São Pauloinstname:Instituto de Medicina Tropical (IMT)instacron:IMTenghttps://www.revistas.usp.br/rimtsp/article/view/173923/162894https://www.revistas.usp.br/rimtsp/article/view/173923/162896Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Pauloinfo:eu-repo/semantics/openAccessFrade, Virgínia PaulaSimões, Nathália SoaresBaldoni, Nayara RagiSanches, CristinaOliveira, Cláudia Di Lorenzo2020-10-26T17:39:25Zoai:revistas.usp.br:article/173923Revistahttp://www.revistas.usp.br/rimtsp/indexPUBhttps://www.revistas.usp.br/rimtsp/oai||revimtsp@usp.br1678-99460036-4665opendoar:2022-12-13T16:52:53.470752Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT)true |
dc.title.none.fl_str_mv |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
title |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
spellingShingle |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review Frade, Virgínia Paula Benznidazole Chagas disease Drug therapy Chronic phase |
title_short |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
title_full |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
title_fullStr |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
title_full_unstemmed |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
title_sort |
Ideal benznidazole dose regimen in chronic chagasic patients: a systematic review |
author |
Frade, Virgínia Paula |
author_facet |
Frade, Virgínia Paula Simões, Nathália Soares Baldoni, Nayara Ragi Sanches, Cristina Oliveira, Cláudia Di Lorenzo |
author_role |
author |
author2 |
Simões, Nathália Soares Baldoni, Nayara Ragi Sanches, Cristina Oliveira, Cláudia Di Lorenzo |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Frade, Virgínia Paula Simões, Nathália Soares Baldoni, Nayara Ragi Sanches, Cristina Oliveira, Cláudia Di Lorenzo |
dc.subject.por.fl_str_mv |
Benznidazole Chagas disease Drug therapy Chronic phase |
topic |
Benznidazole Chagas disease Drug therapy Chronic phase |
description |
The present study aimed to review the existing literature and to evaluate the best dose regimen for benznidazole in adult patients with Chagas disease in the chronic phase. A systematic review was conducted followed by meta-analysis. Searches were performed in four databases, to include studies published until May 2019. The descriptors used were: “Chagas disease”, “benznidazole”, “Drug Therapy”, “Pharmacokinetics”, “Dose-response relationship, drug” and “Chronic disease”. The meta-analysis compared studies using the standard dose of 5 mg/kg/day for 30 or 60 days. A total of 608 articles were found, 23 of which were considered eligible for this review and nine were included in the meta-analysis. The studies selected and analyzed were published between 1996 and 2018, with various benznidazole dose regimens, ranging from 2.5 mg/kg/day to 10 mg/kg/day, for 30 to 80 days of treatment. The results pointed to a great diversity of dose regimens, thus there is no consensus on the optimal dose regimen for benznidazole in the chronic phase of Chagas disease. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-08-21 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/173923 10.1590/s1678-9946202062052 |
url |
https://www.revistas.usp.br/rimtsp/article/view/173923 |
identifier_str_mv |
10.1590/s1678-9946202062052 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
https://www.revistas.usp.br/rimtsp/article/view/173923/162894 https://www.revistas.usp.br/rimtsp/article/view/173923/162896 |
dc.rights.driver.fl_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Copyright (c) 2020 Revista do Instituto de Medicina Tropical de São Paulo |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/xml |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
publisher.none.fl_str_mv |
Universidade de São Paulo. Instituto de Medicina Tropical de São Paulo |
dc.source.none.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52 Revista do Instituto de Medicina Tropical de São Paulo; Vol. 62 (2020); e52 Revista do Instituto de Medicina Tropical de São Paulo; v. 62 (2020); e52 1678-9946 0036-4665 reponame:Revista do Instituto de Medicina Tropical de São Paulo instname:Instituto de Medicina Tropical (IMT) instacron:IMT |
instname_str |
Instituto de Medicina Tropical (IMT) |
instacron_str |
IMT |
institution |
IMT |
reponame_str |
Revista do Instituto de Medicina Tropical de São Paulo |
collection |
Revista do Instituto de Medicina Tropical de São Paulo |
repository.name.fl_str_mv |
Revista do Instituto de Medicina Tropical de São Paulo - Instituto de Medicina Tropical (IMT) |
repository.mail.fl_str_mv |
||revimtsp@usp.br |
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1798951652726669312 |