Population pharmacokinetic modeling of benznidazole in Brazilian patients with chronic Chagas disease

• Autor(a) principal: Frade, Virgínia Paula
• Data de Publicação: 2022
• Outros Autores: Moreira, Carlos Henrique Valente, Sabino, Ester Cerdeira, Bedor, Danilo César Galindo, Ghilard, Fábio de Rose, Oliveira, Cláudia Di Lorenzo, Sanches, Cristina
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Revista do Instituto de Medicina Tropical de São Paulo
• Texto Completo: https://www.revistas.usp.br/rimtsp/article/view/194761
• topic: Chagas disease; Benznidazole; Pharmacokinetic

The present study aimed to establish a population pharmacokinetic (PopPK) modeling of benznidazole (BZD) in Brazilian patients with chronic Chagas disease. This was part of a Brazilian prospective cohort study with eight patients diagnosed with Chagas disease during the beginning of BZD treatment up to the 60th day. On the 15th day of treatment, a blood sampling was collected and analyzed. A one-compartment PK model was developed using Pmetrics. Patients with an average age of 50.3 (SD: 6.2) years old, 6 female patients and 2 males, 70.2 kg (14.2), receiving a 5 mg/Kg/day dose were included. PK parameters estimated for CL, V and Ka were 6.27 L/h, 38.97 L and 1.66 h-1, respectively. This is the first study to establish a population pharmacokinetic modeling of BZD in Brazilian patients with chronic Chagas disease. Therefore, further studies are needed to obtain the complete characterization of BZD pharmacokinetics.