Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista Ambiente & Água |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000100310 |
Resumo: | Abstract Tannery is a highly polluting activity due to the waste generated by bovine skin processing. Although there are several studies highlighting the health issues faced by workers exposed to tannery effluent, there are no records of experiments testing the neurobehavioral effects resulting from direct contact with this pollutant. Thus, the aim of the current study is to assess the possible neurobehavioral effects of dermal exposure to tannery effluent on male Swiss mice. Animals were divided in three groups, which were subjected to the same experimental time period and conditions: effluent group - animals in direct contact with tannery effluent (for 20 days); control group - animals in contact with pure water; and dry-control group - animals not exposed to water or to tannery effluent. Neurobehavioral tests started on the 17th experimental day. Results of the elevated plus-maze test (anxiety prediction) showed no anxiogenic or anxiolytic effects, memory deficit or depressive symptoms on animals exposed to tannery effluent. Thus, the current results do not support the hypothesis that male Swiss mice dermal exposure to tannery effluents for the same time period and experimental conditions leads to neurobehavioral changes. Therefore, the herein adopted exposure protocol was not good to study the effects of dermal exposure to tannery effluent on the chosen experimental model. |
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Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss micexenobiotictannery effluentexperimental modeltoxicology.Abstract Tannery is a highly polluting activity due to the waste generated by bovine skin processing. Although there are several studies highlighting the health issues faced by workers exposed to tannery effluent, there are no records of experiments testing the neurobehavioral effects resulting from direct contact with this pollutant. Thus, the aim of the current study is to assess the possible neurobehavioral effects of dermal exposure to tannery effluent on male Swiss mice. Animals were divided in three groups, which were subjected to the same experimental time period and conditions: effluent group - animals in direct contact with tannery effluent (for 20 days); control group - animals in contact with pure water; and dry-control group - animals not exposed to water or to tannery effluent. Neurobehavioral tests started on the 17th experimental day. Results of the elevated plus-maze test (anxiety prediction) showed no anxiogenic or anxiolytic effects, memory deficit or depressive symptoms on animals exposed to tannery effluent. Thus, the current results do not support the hypothesis that male Swiss mice dermal exposure to tannery effluents for the same time period and experimental conditions leads to neurobehavioral changes. Therefore, the herein adopted exposure protocol was not good to study the effects of dermal exposure to tannery effluent on the chosen experimental model.Instituto de Pesquisas Ambientais em Bacias Hidrográficas2018-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000100310Revista Ambiente & Água v.13 n.1 2018reponame:Revista Ambiente & Águainstname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)instacron:IPABHI10.4136/ambi-agua.2143info:eu-repo/semantics/openAccessMendes,Bruna de OliveiraGuimarães,Abraão Tiago BatistaSouza,Joyce Moreira deFerreira,Raíssa de OliveiraSilva,Wellington Alves Mizael daRodrigues,Aline Sueli de LimaMalafaia,Guilhermeeng2018-02-23T00:00:00Zoai:scielo:S1980-993X2018000100310Revistahttp://www.ambi-agua.net/PUBhttps://old.scielo.br/oai/scielo-oai.php||ambi.agua@gmail.com1980-993X1980-993Xopendoar:2018-02-23T00:00Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI)false |
dc.title.none.fl_str_mv |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
title |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
spellingShingle |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice Mendes,Bruna de Oliveira xenobiotic tannery effluent experimental model toxicology. |
title_short |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
title_full |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
title_fullStr |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
title_full_unstemmed |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
title_sort |
Short-term dermal exposure to tannery effluent does not cause behavioral changes in male Swiss mice |
author |
Mendes,Bruna de Oliveira |
author_facet |
Mendes,Bruna de Oliveira Guimarães,Abraão Tiago Batista Souza,Joyce Moreira de Ferreira,Raíssa de Oliveira Silva,Wellington Alves Mizael da Rodrigues,Aline Sueli de Lima Malafaia,Guilherme |
author_role |
author |
author2 |
Guimarães,Abraão Tiago Batista Souza,Joyce Moreira de Ferreira,Raíssa de Oliveira Silva,Wellington Alves Mizael da Rodrigues,Aline Sueli de Lima Malafaia,Guilherme |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Mendes,Bruna de Oliveira Guimarães,Abraão Tiago Batista Souza,Joyce Moreira de Ferreira,Raíssa de Oliveira Silva,Wellington Alves Mizael da Rodrigues,Aline Sueli de Lima Malafaia,Guilherme |
dc.subject.por.fl_str_mv |
xenobiotic tannery effluent experimental model toxicology. |
topic |
xenobiotic tannery effluent experimental model toxicology. |
description |
Abstract Tannery is a highly polluting activity due to the waste generated by bovine skin processing. Although there are several studies highlighting the health issues faced by workers exposed to tannery effluent, there are no records of experiments testing the neurobehavioral effects resulting from direct contact with this pollutant. Thus, the aim of the current study is to assess the possible neurobehavioral effects of dermal exposure to tannery effluent on male Swiss mice. Animals were divided in three groups, which were subjected to the same experimental time period and conditions: effluent group - animals in direct contact with tannery effluent (for 20 days); control group - animals in contact with pure water; and dry-control group - animals not exposed to water or to tannery effluent. Neurobehavioral tests started on the 17th experimental day. Results of the elevated plus-maze test (anxiety prediction) showed no anxiogenic or anxiolytic effects, memory deficit or depressive symptoms on animals exposed to tannery effluent. Thus, the current results do not support the hypothesis that male Swiss mice dermal exposure to tannery effluents for the same time period and experimental conditions leads to neurobehavioral changes. Therefore, the herein adopted exposure protocol was not good to study the effects of dermal exposure to tannery effluent on the chosen experimental model. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000100310 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1980-993X2018000100310 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.4136/ambi-agua.2143 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas |
publisher.none.fl_str_mv |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas |
dc.source.none.fl_str_mv |
Revista Ambiente & Água v.13 n.1 2018 reponame:Revista Ambiente & Água instname:Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) instacron:IPABHI |
instname_str |
Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) |
instacron_str |
IPABHI |
institution |
IPABHI |
reponame_str |
Revista Ambiente & Água |
collection |
Revista Ambiente & Água |
repository.name.fl_str_mv |
Revista Ambiente & Água - Instituto de Pesquisas Ambientais em Bacias Hidrográficas (IPABHI) |
repository.mail.fl_str_mv |
||ambi.agua@gmail.com |
_version_ |
1752129750336274432 |