Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine

Detalhes bibliográficos
Autor(a) principal: MELLO, Luiz Carlos de Paula
Data de Publicação: 2023
Outros Autores: GOMIDE, Liana Barbaresco
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9942
Resumo: ObjectiveThis study investigated the effects of supplemental fluorine on the bone characteristics of ovariectomized (castrated) female rats, used as a model for experimental osteoporosis, evaluating the correlation between biomechanical parameters and the physical and chemical bone properties.MethodsSeventy-eight female, 4-month-old Wistar rats were divided into 8 groups: the basal group, generating the initial values for the parameters; group 1, consisting of non-ovariectomized rats; and groups 2 to 7, consisting of ovariectomized rats that ingested increasing concentrations of supplemental sodium fluoride solutions (NaF): 0, 20, 40, 60, 80 and 100mg/L, respectively, for two months.ResultsOvariectomy promoted osteopenia, determined from the morphometric, physical and chemical parameters and causing lower biomechanical resistance of the femurs submitted to flexion trials. The bones of the rats that ingested the 40mg/L fluorine solution demonstrated better physical, biochemical and biomechanical conditions than those of the non-treated ovariectomized and intact control rats.ConclusionBesides promoting protection against the bone loss induced by estrogen deficiency, fluorine improved bone quality, which was demonstrated by the enhanced biomechanical results as compared to the intact group
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spelling Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorineRespostas físicas, químicas e biomecânicas do osso de ratas ovariectomizadas submetidas a diversas ingestões de flúor suplementarbiomechanicsfluorinemenopauseosteoporosisovariectomybiomecânicaflúormenopausaosteoporoseovariectomiaObjectiveThis study investigated the effects of supplemental fluorine on the bone characteristics of ovariectomized (castrated) female rats, used as a model for experimental osteoporosis, evaluating the correlation between biomechanical parameters and the physical and chemical bone properties.MethodsSeventy-eight female, 4-month-old Wistar rats were divided into 8 groups: the basal group, generating the initial values for the parameters; group 1, consisting of non-ovariectomized rats; and groups 2 to 7, consisting of ovariectomized rats that ingested increasing concentrations of supplemental sodium fluoride solutions (NaF): 0, 20, 40, 60, 80 and 100mg/L, respectively, for two months.ResultsOvariectomy promoted osteopenia, determined from the morphometric, physical and chemical parameters and causing lower biomechanical resistance of the femurs submitted to flexion trials. The bones of the rats that ingested the 40mg/L fluorine solution demonstrated better physical, biochemical and biomechanical conditions than those of the non-treated ovariectomized and intact control rats.ConclusionBesides promoting protection against the bone loss induced by estrogen deficiency, fluorine improved bone quality, which was demonstrated by the enhanced biomechanical results as compared to the intact groupObjetivoEste estudo investiga os efeitos do flúor suplementar sobre as características dos ossos de ratas ovariectomizadas (castradas), utilizadas como modelo de osteoporose experimental, por meio da correlação entre os parâmetros biomecânicos e as propriedades físicas e químicas desses ossos. MétodosNo início do experimento, 78 ratas Wistar, com quatro meses de idade, foram divididas em oito grupos: grupo basal, que gerou os parâmetros iniciais do experimento; grupo 1, formado por ratas não ovariectomizadas; e os grupos 2 a 7, constituídos por ratas ovariectomizadas submetidas a dosagens de fluoreto de sódio (NaF) de 0, 20, 40, 60, 80 e 100mg/L em solução, respectivamente, durante dois meses.ResultadosA ovariectomia promoveu osteopenia, observada pelos parâmetros morfométricos, físicos e químicos, provocando menor resistência biomecânica dos fêmures submetidos ao ensaio de flexão. Os ossos das ratas que ingeriram 40mg de flúor demonstraram melhores características físicas, bioquímicas e biomecânicas do que os das ratas ovariectomizadas sem tratamento e os das não ovariectomizadas. ConclusãoAlém de promover uma proteção contra a perda óssea induzida pela deficiência de estrógenos causada pela castração, o flúor melhorou a qualidade óssea, demonstrada pelos resultados biomecânicos aumentados em relação ao grupo não ovariectomizado.Núcleo de Editoração – PUC-Campinas2023-10-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9942Brazilian Journal of Nutrition; Vol. 18 No. 5 (2005): Revista de NutriçãoRevista de Nutrição; Vol. 18 Núm. 5 (2005): Revista de NutriçãoRevista de Nutrição; v. 18 n. 5 (2005): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9942/7274Copyright (c) 2023 Luiz Carlos de Paula MELLO, Liana Barbaresco GOMIDEhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccessMELLO, Luiz Carlos de Paula GOMIDE, Liana Barbaresco 2023-10-04T13:42:31Zoai:ojs.periodicos.puc-campinas.edu.br:article/9942Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-10-04T13:42:31Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
Respostas físicas, químicas e biomecânicas do osso de ratas ovariectomizadas submetidas a diversas ingestões de flúor suplementar
title Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
spellingShingle Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
MELLO, Luiz Carlos de Paula
biomechanics
fluorine
menopause
osteoporosis
ovariectomy
biomecânica
flúor
menopausa
osteoporose
ovariectomia
title_short Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
title_full Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
title_fullStr Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
title_full_unstemmed Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
title_sort Physical, chemical and biomechanical bone response of female ovariectomized rats to various intakes of supplemental fluorine
author MELLO, Luiz Carlos de Paula
author_facet MELLO, Luiz Carlos de Paula
GOMIDE, Liana Barbaresco
author_role author
author2 GOMIDE, Liana Barbaresco
author2_role author
dc.contributor.author.fl_str_mv MELLO, Luiz Carlos de Paula
GOMIDE, Liana Barbaresco
dc.subject.por.fl_str_mv biomechanics
fluorine
menopause
osteoporosis
ovariectomy
biomecânica
flúor
menopausa
osteoporose
ovariectomia
topic biomechanics
fluorine
menopause
osteoporosis
ovariectomy
biomecânica
flúor
menopausa
osteoporose
ovariectomia
description ObjectiveThis study investigated the effects of supplemental fluorine on the bone characteristics of ovariectomized (castrated) female rats, used as a model for experimental osteoporosis, evaluating the correlation between biomechanical parameters and the physical and chemical bone properties.MethodsSeventy-eight female, 4-month-old Wistar rats were divided into 8 groups: the basal group, generating the initial values for the parameters; group 1, consisting of non-ovariectomized rats; and groups 2 to 7, consisting of ovariectomized rats that ingested increasing concentrations of supplemental sodium fluoride solutions (NaF): 0, 20, 40, 60, 80 and 100mg/L, respectively, for two months.ResultsOvariectomy promoted osteopenia, determined from the morphometric, physical and chemical parameters and causing lower biomechanical resistance of the femurs submitted to flexion trials. The bones of the rats that ingested the 40mg/L fluorine solution demonstrated better physical, biochemical and biomechanical conditions than those of the non-treated ovariectomized and intact control rats.ConclusionBesides promoting protection against the bone loss induced by estrogen deficiency, fluorine improved bone quality, which was demonstrated by the enhanced biomechanical results as compared to the intact group
publishDate 2023
dc.date.none.fl_str_mv 2023-10-04
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9942
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9942
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9942/7274
dc.rights.driver.fl_str_mv Copyright (c) 2023 Luiz Carlos de Paula MELLO, Liana Barbaresco GOMIDE
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Luiz Carlos de Paula MELLO, Liana Barbaresco GOMIDE
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 18 No. 5 (2005): Revista de Nutrição
Revista de Nutrição; Vol. 18 Núm. 5 (2005): Revista de Nutrição
Revista de Nutrição; v. 18 n. 5 (2005): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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