Omega-3 fatty acids reduce the development of preneoplasic lesions
Autor(a) principal: | |
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Data de Publicação: | 2009 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Revista de Nutrição |
Texto Completo: | http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732009000200006 |
Resumo: | OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis. |
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Omega-3 fatty acids reduce the development of preneoplasic lesionsFatty acidsPrecancerousDietary supplementsOBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis.Pontifícia Universidade Católica de Campinas2009-04-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732009000200006Revista de Nutrição v.22 n.2 2009reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMP10.1590/S1415-52732009000200006info:eu-repo/semantics/openAccessHenriques,Viviana TeixeiraDias,Cristina Maria Ganns ChavesFranceschini,Sylvia do Carmo CastroSabarense,Céphora MariaCosta,Neuza Maria BrunoroLeite,Jacqueline Isaura AlvarezPeluzio,Maria do Carmo Gouveiaeng2009-06-16T00:00:00Zoai:scielo:S1415-52732009000200006Revistahttp://www.scielo.br/rnONGhttps://old.scielo.br/oai/scielo-oai.php||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2009-06-16T00:00Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false |
dc.title.none.fl_str_mv |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
title |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
spellingShingle |
Omega-3 fatty acids reduce the development of preneoplasic lesions Henriques,Viviana Teixeira Fatty acids Precancerous Dietary supplements |
title_short |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
title_full |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
title_fullStr |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
title_full_unstemmed |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
title_sort |
Omega-3 fatty acids reduce the development of preneoplasic lesions |
author |
Henriques,Viviana Teixeira |
author_facet |
Henriques,Viviana Teixeira Dias,Cristina Maria Ganns Chaves Franceschini,Sylvia do Carmo Castro Sabarense,Céphora Maria Costa,Neuza Maria Brunoro Leite,Jacqueline Isaura Alvarez Peluzio,Maria do Carmo Gouveia |
author_role |
author |
author2 |
Dias,Cristina Maria Ganns Chaves Franceschini,Sylvia do Carmo Castro Sabarense,Céphora Maria Costa,Neuza Maria Brunoro Leite,Jacqueline Isaura Alvarez Peluzio,Maria do Carmo Gouveia |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Henriques,Viviana Teixeira Dias,Cristina Maria Ganns Chaves Franceschini,Sylvia do Carmo Castro Sabarense,Céphora Maria Costa,Neuza Maria Brunoro Leite,Jacqueline Isaura Alvarez Peluzio,Maria do Carmo Gouveia |
dc.subject.por.fl_str_mv |
Fatty acids Precancerous Dietary supplements |
topic |
Fatty acids Precancerous Dietary supplements |
description |
OBJECTIVE: The purpose of this study was to evaluate the anticancer potential of dietary omega-3 supplementation to reduce induced intestinal preneoplastic lesions in Wistar rats. METHODS: A total of 58 11-week-old male Wistar rats (Rattus norvergicus, albinus variety, Rodentia) were distributed into two groups: a control group (n=25) and an omega-3-treated group (n=28). Aberrant crypt foci were induced by 1,2-dimethylhydrazine. Tissue incorporation of the supplemented omega-3 fatty acids was evaluated by determining the fatty acid profiles of intra-abdominal fat and the liver with gas chromatography. RESULTS: The omega-3 group presented lower weight and lower food intake (p<0.05) than the control group. The number of aberrant crypt foci decreased 55.34% in response to omega-3 supplementation. Foci with more than three crypts decreased 57.14% between weeks 13 and 28. There was no statistical difference for the docosahexaenoic acid content in the liver of the omega-3 group between week 6 and weeks 13 and 28. CONCLUSION: These results suggest that omega-3 may slow the progress of colorectal carcinogenesis. |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-04-01 |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732009000200006 |
url |
http://old.scielo.br/scielo.php?script=sci_arttext&pid=S1415-52732009000200006 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1590/S1415-52732009000200006 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
text/html |
dc.publisher.none.fl_str_mv |
Pontifícia Universidade Católica de Campinas |
publisher.none.fl_str_mv |
Pontifícia Universidade Católica de Campinas |
dc.source.none.fl_str_mv |
Revista de Nutrição v.22 n.2 2009 reponame:Revista de Nutrição instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) instacron:PUC_CAMP |
instname_str |
Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
instacron_str |
PUC_CAMP |
institution |
PUC_CAMP |
reponame_str |
Revista de Nutrição |
collection |
Revista de Nutrição |
repository.name.fl_str_mv |
Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS) |
repository.mail.fl_str_mv |
||sbi.submissionrn@puc-campinas.edu.br |
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1752128817363681280 |