Nutrition in the post-genome era: ‘omic’ tools basics and applications

Detalhes bibliográficos
Autor(a) principal: FIALHO, Eliane
Data de Publicação: 2023
Outros Autores: Salvador MORENO, Fernando, Prates ONG, Thomas
Tipo de documento: Artigo
Idioma: por
Título da fonte: Revista de Nutrição
Texto Completo: https://periodicos.puc-campinas.edu.br/nutricao/article/view/9630
Resumo: After sequencing the human genome, genomic studies have been focusing on elucidating the function of all genes, as well as characterizing their interactions with environmental factors. Nutrigenomics emerged in the pos-genome era and is considered a key-area for nutrition in the present decade. Its research focus is nutrientgene interaction. The main objective of this recent science is to establish personalized genotype-based diets that promote health and reduce the risk of non-communicable chronic diseases such as cardiovascular diseases, cancer, diabetes and others. In this context, it is essential to use functional genomic tools to analyze the transcriptome (transcriptomics), proteome (proteomics) and metabolome (metabolomics) in the field of nutrition. The applicabilities of such methodologies in nutritional studies seem unlimited since they can be conducted in cell cultures, animal models and pre-clinical and clinical studies. Such techniques may allow one to identify biomarkers that respond specifically to a certain dietary nutrient or bioactive compound and to establish the best individual dietary advice to reduce the risk of non-communicable chronic diseases and promote health.
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spelling Nutrition in the post-genome era: ‘omic’ tools basics and applicationsNutrição no pós-genoma: fundamentos e aplicações de ferramentas ômicasNutrition public healthNutrigenomicsTranscriptomicsProteomicsNutrição em saúde públicaNutrigenômicaTranscritômicaProteômicaAfter sequencing the human genome, genomic studies have been focusing on elucidating the function of all genes, as well as characterizing their interactions with environmental factors. Nutrigenomics emerged in the pos-genome era and is considered a key-area for nutrition in the present decade. Its research focus is nutrientgene interaction. The main objective of this recent science is to establish personalized genotype-based diets that promote health and reduce the risk of non-communicable chronic diseases such as cardiovascular diseases, cancer, diabetes and others. In this context, it is essential to use functional genomic tools to analyze the transcriptome (transcriptomics), proteome (proteomics) and metabolome (metabolomics) in the field of nutrition. The applicabilities of such methodologies in nutritional studies seem unlimited since they can be conducted in cell cultures, animal models and pre-clinical and clinical studies. Such techniques may allow one to identify biomarkers that respond specifically to a certain dietary nutrient or bioactive compound and to establish the best individual dietary advice to reduce the risk of non-communicable chronic diseases and promote health.Após seqüenciamento do genoma humano, os estudos genômicos têm se voltado à elucidação das funções de todos os genes, bem como à caracterização de suas interações com fatores ambientais. A nutrigenômica surgiu no contexto do pós-genoma humano e é considerada área-chave para a nutrição nesta década. Seu foco de estudo baseia-se na interação gene-nutriente. Esta ciência recente tem como objetivo principal o estabelecimento de dietas personalizadas, com base no genótipo, para a promoção da saúde e a redução do risco de doenças crônicas não transmissíveis como as cardiovasculares, o câncer, o diabetes, entre outras. Nesse contexto, é fundamental a aplicação na área de nutrição das ferramentas de genômica funcional para análise do transcritoma (transcritômica), do proteoma (proteômica) e do metaboloma (metabolômica). As aplicabilidades dessas metodologias em estudos nutricionais parecem ilimitadas, pois podem ser conduzidas em cultura de células, modelos de experimentação em animais, estudos pré-clinicos e clínicos. Tais técnicas apresentam potencial para identificar biomarcadores que respondem especificamente a um determinado nutriente ou composto bioativo dos alimentos e para estabelecer as melhores recomendações dietéticas individuais para redução do risco das doenças crônicas não transmissíveis e promoção da saúde. Núcleo de Editoração – PUC-Campinas2023-09-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9630Brazilian Journal of Nutrition; Vol. 21 No. 6 (2008): Revista de NutriçãoRevista de Nutrição; Vol. 21 Núm. 6 (2008): Revista de NutriçãoRevista de Nutrição; v. 21 n. 6 (2008): Revista de Nutrição1678-9865reponame:Revista de Nutriçãoinstname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)instacron:PUC_CAMPporhttps://periodicos.puc-campinas.edu.br/nutricao/article/view/9630/6982Copyright (c) 2023 Eliane FIALHO, Fernando Salvador MORENO, Thomas Prates ONGhttps://creativecommons.org/licenses/by/4.0info:eu-repo/semantics/openAccess FIALHO, Eliane Salvador MORENO, Fernando Prates ONG, Thomas2023-09-05T13:33:57Zoai:ojs.periodicos.puc-campinas.edu.br:article/9630Revistahttp://www.scielo.br/rnPRIhttps://periodicos.puc-campinas.edu.br/nutricao/oai||sbi.submissionrn@puc-campinas.edu.br1678-98651415-5273opendoar:2023-09-05T13:33:57Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)false
dc.title.none.fl_str_mv Nutrition in the post-genome era: ‘omic’ tools basics and applications
Nutrição no pós-genoma: fundamentos e aplicações de ferramentas ômicas
title Nutrition in the post-genome era: ‘omic’ tools basics and applications
spellingShingle Nutrition in the post-genome era: ‘omic’ tools basics and applications
FIALHO, Eliane
Nutrition public health
Nutrigenomics
Transcriptomics
Proteomics
Nutrição em saúde pública
Nutrigenômica
Transcritômica
Proteômica
title_short Nutrition in the post-genome era: ‘omic’ tools basics and applications
title_full Nutrition in the post-genome era: ‘omic’ tools basics and applications
title_fullStr Nutrition in the post-genome era: ‘omic’ tools basics and applications
title_full_unstemmed Nutrition in the post-genome era: ‘omic’ tools basics and applications
title_sort Nutrition in the post-genome era: ‘omic’ tools basics and applications
author FIALHO, Eliane
author_facet FIALHO, Eliane
Salvador MORENO, Fernando
Prates ONG, Thomas
author_role author
author2 Salvador MORENO, Fernando
Prates ONG, Thomas
author2_role author
author
dc.contributor.author.fl_str_mv FIALHO, Eliane
Salvador MORENO, Fernando
Prates ONG, Thomas
dc.subject.por.fl_str_mv Nutrition public health
Nutrigenomics
Transcriptomics
Proteomics
Nutrição em saúde pública
Nutrigenômica
Transcritômica
Proteômica
topic Nutrition public health
Nutrigenomics
Transcriptomics
Proteomics
Nutrição em saúde pública
Nutrigenômica
Transcritômica
Proteômica
description After sequencing the human genome, genomic studies have been focusing on elucidating the function of all genes, as well as characterizing their interactions with environmental factors. Nutrigenomics emerged in the pos-genome era and is considered a key-area for nutrition in the present decade. Its research focus is nutrientgene interaction. The main objective of this recent science is to establish personalized genotype-based diets that promote health and reduce the risk of non-communicable chronic diseases such as cardiovascular diseases, cancer, diabetes and others. In this context, it is essential to use functional genomic tools to analyze the transcriptome (transcriptomics), proteome (proteomics) and metabolome (metabolomics) in the field of nutrition. The applicabilities of such methodologies in nutritional studies seem unlimited since they can be conducted in cell cultures, animal models and pre-clinical and clinical studies. Such techniques may allow one to identify biomarkers that respond specifically to a certain dietary nutrient or bioactive compound and to establish the best individual dietary advice to reduce the risk of non-communicable chronic diseases and promote health.
publishDate 2023
dc.date.none.fl_str_mv 2023-09-05
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9630
url https://periodicos.puc-campinas.edu.br/nutricao/article/view/9630
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv https://periodicos.puc-campinas.edu.br/nutricao/article/view/9630/6982
dc.rights.driver.fl_str_mv Copyright (c) 2023 Eliane FIALHO, Fernando Salvador MORENO, Thomas Prates ONG
https://creativecommons.org/licenses/by/4.0
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Copyright (c) 2023 Eliane FIALHO, Fernando Salvador MORENO, Thomas Prates ONG
https://creativecommons.org/licenses/by/4.0
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
publisher.none.fl_str_mv Núcleo de Editoração – PUC-Campinas
dc.source.none.fl_str_mv Brazilian Journal of Nutrition; Vol. 21 No. 6 (2008): Revista de Nutrição
Revista de Nutrição; Vol. 21 Núm. 6 (2008): Revista de Nutrição
Revista de Nutrição; v. 21 n. 6 (2008): Revista de Nutrição
1678-9865
reponame:Revista de Nutrição
instname:Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron:PUC_CAMP
instname_str Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
instacron_str PUC_CAMP
institution PUC_CAMP
reponame_str Revista de Nutrição
collection Revista de Nutrição
repository.name.fl_str_mv Revista de Nutrição - Pontifícia Universidade Católica de Campinas (PUC-CAMPINAS)
repository.mail.fl_str_mv ||sbi.submissionrn@puc-campinas.edu.br
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