Influence of immunosuppressants on bone metabolism and tooth movement: A literature review

Detalhes bibliográficos
Autor(a) principal: Santos, Rogério Lacerda dos
Data de Publicação: 2008
Outros Autores: Gonçalves, Renato Torres, Martins, Marco Aurélio, Souza, Margareth Maria Gomes de
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Revista odonto ciência (Online)
Texto Completo: https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621
Resumo: The objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; bone
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spelling Influence of immunosuppressants on bone metabolism and tooth movement: A literature reviewInfluência dos imunossupressores no metabolismo ósseo e movimento dentário: revisão de literaturaImmunosuppressanttooth movementboneTooth movementThe objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; boneO objetivo desta revisão de literatura é discutir a influência dos imunossupressores no metabolismo ósseo e movimento dentário em Ortodontia. O movimento dentário ocorre em função do processo de remodelação do tecido ósseo e do ligamento periodontal. Existem medicamentos capazes de afetar o metabolismo ósseo e a taxa de movimento dentário, tais como os imunossupressores. Os imunossupressores agem reprimindo a ação dos linfócitos T, podem causar perda óssea e levar a um quadro de osteoporose, a qual é uma complicação comum após os transplantes de rim, coração, fígado e pulmão. Os esquemas imunossupressores para evitar a rejeição do órgão enxertado após o transplante frequentemente incluem glicocorticóides, ciclosporina A, tacrolimus e sirolimus, os quais podem causar efeitos danosos sobre a homeostase mineral óssea. O movimento dentário é dependente da força ortodôntica, dose e duração da terapia imunossupressora, além da resposta individual de cada indivíduo. Assim, todos os pacientes transplantados e usuários de imunossupressores deveriam ser submetidos a monitoramento e prevenção de perda óssea antes e durante o tratamento ortodôntico. Palavras-chave: Imunossupressor; movimento dentário; ossoEDIPUCRS - Editora Universitária da PUCRS2008-08-19info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionPeer-reviewed Article. Invited Article.literature reviewapplication/pdfhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621Revista Odonto Ciência; Vol. 24 No. 1 (2009); 86 - 91Revista Odonto Ciência; v. 24 n. 1 (2009); 86 - 911980-65230102-9460reponame:Revista odonto ciência (Online)instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)instacron:PUC_RSenghttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621/3676Santos, Rogério Lacerda dosGonçalves, Renato TorresMartins, Marco AurélioSouza, Margareth Maria Gomes deinfo:eu-repo/semantics/openAccess2013-11-11T13:23:40Zoai:ojs.revistaseletronicas.pucrs.br:article/3621Revistahttps://revistaseletronicas.pucrs.br/ojs/index.php/foPRIhttps://revistaseletronicas.pucrs.br/ojs/index.php/fo/oai||odontociencia@pucrs.br1980-65230102-9460opendoar:2013-11-11T13:23:40Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)false
dc.title.none.fl_str_mv Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
Influência dos imunossupressores no metabolismo ósseo e movimento dentário: revisão de literatura
title Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
spellingShingle Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
Santos, Rogério Lacerda dos
Immunosuppressant
tooth movement
bone
Tooth movement
title_short Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
title_full Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
title_fullStr Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
title_full_unstemmed Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
title_sort Influence of immunosuppressants on bone metabolism and tooth movement: A literature review
author Santos, Rogério Lacerda dos
author_facet Santos, Rogério Lacerda dos
Gonçalves, Renato Torres
Martins, Marco Aurélio
Souza, Margareth Maria Gomes de
author_role author
author2 Gonçalves, Renato Torres
Martins, Marco Aurélio
Souza, Margareth Maria Gomes de
author2_role author
author
author
dc.contributor.author.fl_str_mv Santos, Rogério Lacerda dos
Gonçalves, Renato Torres
Martins, Marco Aurélio
Souza, Margareth Maria Gomes de
dc.subject.por.fl_str_mv Immunosuppressant
tooth movement
bone
Tooth movement
topic Immunosuppressant
tooth movement
bone
Tooth movement
description The objective of this literature review is to discuss the influence of immunosuppressants on bone metabolism and tooth movement in Orthodontics. Tooth movement occurs as a result of bone and periodontal ligament remodeling. Some medications such as immunosupressants can affect bone metabolism and the rate of tooth movement. Immunosupressants act by repressing the action of T lymphocytes, may cause bone loss, and lead to osteoporosis, which is a common complication following kidney, heart, liver, or lung transplantation. The use of immunosuppressants to prevent rejection after organ transplantation includes glucocorticoids, cyclosporine A, tacrolimus, and sirolimus, which may cause damaging effects on the bone mineral homeostasis. Tooth movement depends on orthodontic force, dosage, and duration of immunosuppressive therapy, and individual response of each patient. Therefore, all patients who have received transplants should be closely monitored to prevent bone loss before and during orthodontic treatment. Key words: Immunosuppressant; tooth movement; bone
publishDate 2008
dc.date.none.fl_str_mv 2008-08-19
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
Peer-reviewed Article. Invited Article.
literature review
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621
url https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv https://revistaseletronicas.pucrs.br/ojs/index.php/fo/article/view/3621/3676
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
publisher.none.fl_str_mv EDIPUCRS - Editora Universitária da PUCRS
dc.source.none.fl_str_mv Revista Odonto Ciência; Vol. 24 No. 1 (2009); 86 - 91
Revista Odonto Ciência; v. 24 n. 1 (2009); 86 - 91
1980-6523
0102-9460
reponame:Revista odonto ciência (Online)
instname:Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron:PUC_RS
instname_str Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
instacron_str PUC_RS
institution PUC_RS
reponame_str Revista odonto ciência (Online)
collection Revista odonto ciência (Online)
repository.name.fl_str_mv Revista odonto ciência (Online) - Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS)
repository.mail.fl_str_mv ||odontociencia@pucrs.br
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