The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats

Detalhes bibliográficos
Autor(a) principal: Ramalhosa, F
Data de Publicação: 2016
Outros Autores: Soares-Cunha, C, Seixal, RM, Sousa, N, Carvalho, AF
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.23/1076
Resumo: Antenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract.
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spelling The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in RatsAbsorção IntestinalExposição MaternaRatosDexametasonaAntenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract.Repositório Científico do Hospital de BragaRamalhosa, FSoares-Cunha, CSeixal, RMSousa, NCarvalho, AF2016-09-16T10:44:40Z2016-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1076engPLoS One. 2016 Sep 1;11(9):e0161750.10.1371/journal.pone.0161750info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:53Zoai:repositorio.hospitaldebraga.pt:10400.23/1076Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:38.657352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
title The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
spellingShingle The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
Ramalhosa, F
Absorção Intestinal
Exposição Materna
Ratos
Dexametasona
title_short The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
title_full The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
title_fullStr The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
title_full_unstemmed The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
title_sort The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
author Ramalhosa, F
author_facet Ramalhosa, F
Soares-Cunha, C
Seixal, RM
Sousa, N
Carvalho, AF
author_role author
author2 Soares-Cunha, C
Seixal, RM
Sousa, N
Carvalho, AF
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Hospital de Braga
dc.contributor.author.fl_str_mv Ramalhosa, F
Soares-Cunha, C
Seixal, RM
Sousa, N
Carvalho, AF
dc.subject.por.fl_str_mv Absorção Intestinal
Exposição Materna
Ratos
Dexametasona
topic Absorção Intestinal
Exposição Materna
Ratos
Dexametasona
description Antenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract.
publishDate 2016
dc.date.none.fl_str_mv 2016-09-16T10:44:40Z
2016-01-01T00:00:00Z
2016-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.23/1076
url http://hdl.handle.net/10400.23/1076
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv PLoS One. 2016 Sep 1;11(9):e0161750.
10.1371/journal.pone.0161750
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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