The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.23/1076 |
Resumo: | Antenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract. |
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The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in RatsAbsorção IntestinalExposição MaternaRatosDexametasonaAntenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract.Repositório Científico do Hospital de BragaRamalhosa, FSoares-Cunha, CSeixal, RMSousa, NCarvalho, AF2016-09-16T10:44:40Z2016-01-01T00:00:00Z2016-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.23/1076engPLoS One. 2016 Sep 1;11(9):e0161750.10.1371/journal.pone.0161750info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-09-21T09:02:53Zoai:repositorio.hospitaldebraga.pt:10400.23/1076Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T15:55:38.657352Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
title |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
spellingShingle |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats Ramalhosa, F Absorção Intestinal Exposição Materna Ratos Dexametasona |
title_short |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
title_full |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
title_fullStr |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
title_full_unstemmed |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
title_sort |
The Impact of Prenatal Exposure to Dexamethasone on Gastrointestinal Function in Rats |
author |
Ramalhosa, F |
author_facet |
Ramalhosa, F Soares-Cunha, C Seixal, RM Sousa, N Carvalho, AF |
author_role |
author |
author2 |
Soares-Cunha, C Seixal, RM Sousa, N Carvalho, AF |
author2_role |
author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Hospital de Braga |
dc.contributor.author.fl_str_mv |
Ramalhosa, F Soares-Cunha, C Seixal, RM Sousa, N Carvalho, AF |
dc.subject.por.fl_str_mv |
Absorção Intestinal Exposição Materna Ratos Dexametasona |
topic |
Absorção Intestinal Exposição Materna Ratos Dexametasona |
description |
Antenatal treatment with synthetic glucocorticoids is commonly used in pregnant women at risk of preterm delivery to accelerate tissue maturation. Exposure to glucocorticoids during development has been hypothesized to underlie different functional gastrointestinal (GI) and motility disorders. Herein, we investigated the impact of in utero exposure to synthetic glucocorticoids (iuGC) on GI function of adult rats. Wistar male rats, born from pregnant dams treated with dexamethasone (DEX), were studied at different ages. Length, histologic analysis, proliferation and apoptosis assays, GI transit, permeability and serotonin (5-HT) content of GI tract were measured. iuGC treatment decreased small intestine size and decreased gut transit. However, iuGC had no impact on intestinal permeability. iuGC differentially impacts the structure and function of the GI tract, which leads to long-lasting alterations in the small intestine that may predispose subjects prone to disorders of the GI tract. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-09-16T10:44:40Z 2016-01-01T00:00:00Z 2016-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.23/1076 |
url |
http://hdl.handle.net/10400.23/1076 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
PLoS One. 2016 Sep 1;11(9):e0161750. 10.1371/journal.pone.0161750 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799130425138872320 |