In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/23334 |
Resumo: | Cardiovascular diseases are one of the leading causes of death globally and the most common pathological process is atherosclerosis. Over the years, these cardiovascular complications have been extensively studied by applying in vivo, in vitro and numerical methods (in silico). In vivo studies represent more accurately the physiological conditions and provide the most realistic data. Nevertheless, these approaches are expensive, and it is complex to control several physiological variables. Hence, the continuous effort to find reliable alternative methods has been growing. In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. However, it is necessary to ensure its accuracy and reliability by comparing the numerical simulations with clinical and experimental data. For this reason, with the progress of the in vitro flow measurement techniques and rapid prototyping, experimental investigation of hemodynamics has gained widespread attention. The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques. |
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In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a reviewBlood analoguesBlood flowCardiovascular diseasesFlow measurementsHemodynamicsIn vitroRapid prototypingStenosisCardiovascular diseases are one of the leading causes of death globally and the most common pathological process is atherosclerosis. Over the years, these cardiovascular complications have been extensively studied by applying in vivo, in vitro and numerical methods (in silico). In vivo studies represent more accurately the physiological conditions and provide the most realistic data. Nevertheless, these approaches are expensive, and it is complex to control several physiological variables. Hence, the continuous effort to find reliable alternative methods has been growing. In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. However, it is necessary to ensure its accuracy and reliability by comparing the numerical simulations with clinical and experimental data. For this reason, with the progress of the in vitro flow measurement techniques and rapid prototyping, experimental investigation of hemodynamics has gained widespread attention. The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the R&D Units Project Scope: UIDB/00319/2020, UIDB/04077/2020, UIDB/00690/2020, UIDB/04436/2020 and NORTE-01-0145-FEDER-030171, NORTE-01-0145-FEDER-029394 funded by COMPETE2020, NORTE 2020, PORTUGAL 2020, Lisb@2020 and FEDER.Biblioteca Digital do IPBCarvalho, Violeta MenesesMaia, InêsSouza, Andrews Victor AlmeidaRibeiro, J.E.Costa, PedroPuga, Hélder FernandesTeixeira, SenhorinhaLima, Rui A.2018-01-19T10:00:00Z20202020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/23334engCarvalho, Violeta; Maia, Inês; Souza, Andrews; Ribeiro, João; Costa, Pedro; Puga, H.; Teixeira, Senhorinha; Lima, Rui A. (2020) - In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review. Open Biomedical Engineering Journal. ISSN 1874-1207. 14:1, p. 87-10210.2174/1874120702014010087info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:52:11Zoai:bibliotecadigital.ipb.pt:10198/23334Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:14:21.380032Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
title |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
spellingShingle |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review Carvalho, Violeta Meneses Blood analogues Blood flow Cardiovascular diseases Flow measurements Hemodynamics In vitro Rapid prototyping Stenosis |
title_short |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
title_full |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
title_fullStr |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
title_full_unstemmed |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
title_sort |
In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review |
author |
Carvalho, Violeta Meneses |
author_facet |
Carvalho, Violeta Meneses Maia, Inês Souza, Andrews Victor Almeida Ribeiro, J.E. Costa, Pedro Puga, Hélder Fernandes Teixeira, Senhorinha Lima, Rui A. |
author_role |
author |
author2 |
Maia, Inês Souza, Andrews Victor Almeida Ribeiro, J.E. Costa, Pedro Puga, Hélder Fernandes Teixeira, Senhorinha Lima, Rui A. |
author2_role |
author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Carvalho, Violeta Meneses Maia, Inês Souza, Andrews Victor Almeida Ribeiro, J.E. Costa, Pedro Puga, Hélder Fernandes Teixeira, Senhorinha Lima, Rui A. |
dc.subject.por.fl_str_mv |
Blood analogues Blood flow Cardiovascular diseases Flow measurements Hemodynamics In vitro Rapid prototyping Stenosis |
topic |
Blood analogues Blood flow Cardiovascular diseases Flow measurements Hemodynamics In vitro Rapid prototyping Stenosis |
description |
Cardiovascular diseases are one of the leading causes of death globally and the most common pathological process is atherosclerosis. Over the years, these cardiovascular complications have been extensively studied by applying in vivo, in vitro and numerical methods (in silico). In vivo studies represent more accurately the physiological conditions and provide the most realistic data. Nevertheless, these approaches are expensive, and it is complex to control several physiological variables. Hence, the continuous effort to find reliable alternative methods has been growing. In the last decades, numerical simulations have been widely used to assess the blood flow behavior in stenotic arteries and, consequently, providing insights into the cardiovascular disease condition, its progression and therapeutic optimization. However, it is necessary to ensure its accuracy and reliability by comparing the numerical simulations with clinical and experimental data. For this reason, with the progress of the in vitro flow measurement techniques and rapid prototyping, experimental investigation of hemodynamics has gained widespread attention. The present work reviews state-of-the-art in vitro macro-scale arterial stenotic biomodels for flow measurements, summarizing the different fabrication methods, blood analogues and highlighting advantages and limitations of the most used techniques. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01-19T10:00:00Z 2020 2020-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/23334 |
url |
http://hdl.handle.net/10198/23334 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Carvalho, Violeta; Maia, Inês; Souza, Andrews; Ribeiro, João; Costa, Pedro; Puga, H.; Teixeira, Senhorinha; Lima, Rui A. (2020) - In vitro biomodels in stenotic arteries to perform blood analogues flow visualizations and measurements: a review. Open Biomedical Engineering Journal. ISSN 1874-1207. 14:1, p. 87-102 10.2174/1874120702014010087 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799135422602805248 |