Evaluation of different natural ingredients as satiety inductors

Detalhes bibliográficos
Autor(a) principal: Mendes, Nuno Eduardo dos Anjos Serra
Data de Publicação: 2012
Tipo de documento: Dissertação
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/8056
Resumo: Dissertation to obtain a Master’s Degree in Chemical and Biochemical Engineering
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spelling Evaluation of different natural ingredients as satiety inductorsObesityLipaseTrypsinThylakoidsPhytochemicalsEnzyme inhibitionDissertation to obtain a Master’s Degree in Chemical and Biochemical EngineeringUsing natural ingredients to combat obesity has emerged as a promising alternative to conventional therapies which present many side effects. Satiety induction by the ingestion of certain natural compounds has been proven to be an interesting strategy. In this context, the present study had the following objectives: - Isolation of rucola, watercress and spinach, plum and tomato waste and cladodes of Opuntia ficus-indica extracts, rich in compounds with the potential to induce a prolonged feeling of satiety - Assess the satiety inducing potential of isolated extracts using two enzymatic methods: - Inhibition of pancreatic lipase, an enzyme responsible for the conversion of complex lipids into simple and easily absorbable fat, which when inhibited is associated with a prolongation of satiety and a reduction in fat absorption, being the therapeutic target of Orlistat (the most common anti-obesity drug) - Inhibition of trypsin’s proteolytic activity, which is associated with a prolongation of satiety as it promotes the secretion of cholecystokinin (CCK), a polypeptide which regulates pancreatic enzyme release, which not only promotes satiety but also slows gastric emptying. In this work a method for extracting thylakoids, which are potent inhibitors of pancreatic lipase,was optimized. In addition to spinach, this method was applied for the first time to rucola and watercress. The extracts from these three matrixes exhibited lipase inhibitory activity, with spinach being the most efficient one. Hydroalcoholic extracts were prepared from plum residue, rich in polyphenols and saponins, which also showed efficient inhibitory capacity of pancreatic lipase. A protocol was optimized for the extraction of proteins which applied to the plum residue,tomatoes and cladodes of Opuntia ficus-indica. Only the opuntia and tomato extracts presented effective inhibition of trypsin’s proteolytic activity.Faculdade de Ciências e TecnologiaDuarte, CatarinaNunes, SaraRUNMendes, Nuno Eduardo dos Anjos Serra2012-10-30T15:09:21Z20122012-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/8056enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:40:27Zoai:run.unl.pt:10362/8056Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:17:54.780061Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Evaluation of different natural ingredients as satiety inductors
title Evaluation of different natural ingredients as satiety inductors
spellingShingle Evaluation of different natural ingredients as satiety inductors
Mendes, Nuno Eduardo dos Anjos Serra
Obesity
Lipase
Trypsin
Thylakoids
Phytochemicals
Enzyme inhibition
title_short Evaluation of different natural ingredients as satiety inductors
title_full Evaluation of different natural ingredients as satiety inductors
title_fullStr Evaluation of different natural ingredients as satiety inductors
title_full_unstemmed Evaluation of different natural ingredients as satiety inductors
title_sort Evaluation of different natural ingredients as satiety inductors
author Mendes, Nuno Eduardo dos Anjos Serra
author_facet Mendes, Nuno Eduardo dos Anjos Serra
author_role author
dc.contributor.none.fl_str_mv Duarte, Catarina
Nunes, Sara
RUN
dc.contributor.author.fl_str_mv Mendes, Nuno Eduardo dos Anjos Serra
dc.subject.por.fl_str_mv Obesity
Lipase
Trypsin
Thylakoids
Phytochemicals
Enzyme inhibition
topic Obesity
Lipase
Trypsin
Thylakoids
Phytochemicals
Enzyme inhibition
description Dissertation to obtain a Master’s Degree in Chemical and Biochemical Engineering
publishDate 2012
dc.date.none.fl_str_mv 2012-10-30T15:09:21Z
2012
2012-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/8056
url http://hdl.handle.net/10362/8056
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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