Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients

Detalhes bibliográficos
Autor(a) principal: Costa, João
Data de Publicação: 2006
Outros Autores: Valls-Solé, Josep, Valldeoriola, Francesc, Pech, Clemens, Rumià, Jordi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10451/47769
Resumo: © The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
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spelling Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patientsSubthalamic nucleusDeep brain stimulationPrepulse inhibitionBlink reflexParkinson’s disease© The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.The disordered output from the basal ganglia to the pontine tegmentum nuclei is considered responsible for a number of abnormalities in brainstem reflexes in patients with Parkinson's disease. One of the most conspicuous of these abnormalities is the reduced inhibition of the blink reflex by a prepulse stimulus. The circuit of prepulse inhibition involves structures and fibre groups that can be reached by stimuli applied through the electrodes implanted in the subthalamic nucleus for deep brain stimulation (STNDBS). In seven Parkinson's disease patients we examined whether single STNDBS induced prepulse effects on the blink reflex and how they compared with the effects induced by single auditory and somatosensory stimuli. Prepulse inhibition was determined by measuring the percentage inhibition induced in the R2 component of the orbicularis oculi response to supraorbital nerve stimuli. The inter-stimuli intervals (ISI) between the prepulse and the supraorbital nerve stimuli were 0 to 30 ms and 100 ms for single STNDBS and 100 ms for auditory and somatosensory modalities. The results obtained with acoustic and somatosensory stimuli were compared with those obtained from a group of 20 age-matched healthy subjects. Single STNDBS induced significant inhibition of the R2 in all patients at ISIs between 10 and 30 ms, with a mean percentage inhibition of 94% at the ISI of 30 ms. On the contrary, significant inhibition by auditory or somatosensory stimuli was induced in only two out of the seven patients. The mean percentage inhibition at the ISI of 100 ms was 37% for auditory and 40% for somatosensory stimuli, well below reference limits for prepulse inhibition in control subjects (61%). Single STNDBS induces significant prepulse inhibition of the blink reflex in Parkinson's disease patients who have abnormally reduced auditory and somatosensory prepulse effects. This finding helps define the prepulse circuit in humans and the eventual site of its dysfunction in Parkinson's disease.This work was in part accomplished thanks to grant P1040970 from FIS. J.C. has received a scholarship from the non-government Calouste Gulbenkian FoundationOxford University PressRepositório da Universidade de LisboaCosta, JoãoValls-Solé, JosepValldeoriola, FrancescPech, ClemensRumià, Jordi2021-05-11T16:05:58Z2006-072006-07-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/47769engBrain. 2006 Jul; 129 (Pt 7): 1758-17670006-895010.1093/brain/awl1431460-2156info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:50:55Zoai:repositorio.ul.pt:10451/47769Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:59:45.852500Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
title Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
spellingShingle Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
Costa, João
Subthalamic nucleus
Deep brain stimulation
Prepulse inhibition
Blink reflex
Parkinson’s disease
title_short Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
title_full Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
title_fullStr Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
title_full_unstemmed Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
title_sort Single subthalamic nucleus deep brain stimuli inhibit the blink reflex in Parkinson's disease patients
author Costa, João
author_facet Costa, João
Valls-Solé, Josep
Valldeoriola, Francesc
Pech, Clemens
Rumià, Jordi
author_role author
author2 Valls-Solé, Josep
Valldeoriola, Francesc
Pech, Clemens
Rumià, Jordi
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Repositório da Universidade de Lisboa
dc.contributor.author.fl_str_mv Costa, João
Valls-Solé, Josep
Valldeoriola, Francesc
Pech, Clemens
Rumià, Jordi
dc.subject.por.fl_str_mv Subthalamic nucleus
Deep brain stimulation
Prepulse inhibition
Blink reflex
Parkinson’s disease
topic Subthalamic nucleus
Deep brain stimulation
Prepulse inhibition
Blink reflex
Parkinson’s disease
description © The Author (2006). Published by Oxford University Press on behalf of the Guarantors of Brain. All rights reserved.
publishDate 2006
dc.date.none.fl_str_mv 2006-07
2006-07-01T00:00:00Z
2021-05-11T16:05:58Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10451/47769
url http://hdl.handle.net/10451/47769
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brain. 2006 Jul; 129 (Pt 7): 1758-1767
0006-8950
10.1093/brain/awl143
1460-2156
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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