Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2023 |
| Outros Autores: | , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/160678 |
Resumo: | Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship ( SFRH/BD/143797/2019 ) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship (SFRH/BD/143797/2019) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Publisher Copyright: © 2023 |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's diseaseAn analysis of survival and disability milestonesDeep brain stimulationDisabilityMilestonesMortalityParkinson's diseaseSubthalamic nucleusNeurologyGeriatrics and GerontologyClinical NeurologyFunding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship ( SFRH/BD/143797/2019 ) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship (SFRH/BD/143797/2019) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Publisher Copyright: © 2023Background: Data on the long-term survival and incidence of disability milestones after subthalamic nucleus deep brain stimulation (STN-DBS) in Parkinson's disease (PD) is limited. Objectives: To estimate mortality and assess the frequency/time-to-development of disability milestones (falls, freezing, hallucinations, dementia, and institutionalization) among PD patients post STN-DBS. Methods: A longitudinal retrospective study of patients undergoing STN-DBS. For mortality, Cox proportional hazards regression analysis was performed. For disease milestones, competing risk analyses were performed and cumulative incidence functions reported. The strength of association between baselines features and event occurrence was calculated based on adjusted hazard ratios. Results: The overall mortality for the 109 patients was 16 % (62.1 ± 21.3 months after surgery). Falls (73 %) and freezing (47 %) were both the earliest (40.4 ± 25.4 and 39.6 ± 28.4 months, respectively) and most frequent milestones. Dementia (34 %) and hallucinations (32 %) soon followed (56.2 ± 21.2 and mean 60.0 ± 20.7 months after surgery, respectively). Higher ADL scores in the OFF state and higher age at surgery were associated with falls, freezing, dementia and institutionalization. Conclusions: Long-term mortality rate is low after STN-DBS. Disease milestones occur later during the disease course, with motor milestones appearing first and at a higher frequency than cognitive ones.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)RUNBarbosa, RaquelGuedes, Leonor CorreiaCattoni, Maria BegoñaLobo, Patricia PitaCaldas, Ana CastroFabbri, MargheritaBastos, PauloValadas, AnabelaCarvalho, HerculanoAlbuquerque, LuisaReimão, SofiaFerreira, A. GonçalvesFerreira, Joaquim J.Rosa, Mário MiguelCoelho, Miguel2023-11-28T22:38:01Z2024-012024-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/160678eng1353-8020PURE: 76898691https://doi.org/10.1016/j.parkreldis.2023.105921info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:43:26Zoai:run.unl.pt:10362/160678Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:58:10.450272Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease An analysis of survival and disability milestones |
| title |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| spellingShingle |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease Barbosa, Raquel Deep brain stimulation Disability Milestones Mortality Parkinson's disease Subthalamic nucleus Neurology Geriatrics and Gerontology Clinical Neurology |
| title_short |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| title_full |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| title_fullStr |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| title_full_unstemmed |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| title_sort |
Long-term follow-up of subthalamic nucleus deep brain stimulation in patients with Parkinson's disease |
| author |
Barbosa, Raquel |
| author_facet |
Barbosa, Raquel Guedes, Leonor Correia Cattoni, Maria Begoña Lobo, Patricia Pita Caldas, Ana Castro Fabbri, Margherita Bastos, Paulo Valadas, Anabela Carvalho, Herculano Albuquerque, Luisa Reimão, Sofia Ferreira, A. Gonçalves Ferreira, Joaquim J. Rosa, Mário Miguel Coelho, Miguel |
| author_role |
author |
| author2 |
Guedes, Leonor Correia Cattoni, Maria Begoña Lobo, Patricia Pita Caldas, Ana Castro Fabbri, Margherita Bastos, Paulo Valadas, Anabela Carvalho, Herculano Albuquerque, Luisa Reimão, Sofia Ferreira, A. Gonçalves Ferreira, Joaquim J. Rosa, Mário Miguel Coelho, Miguel |
| author2_role |
author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM) RUN |
| dc.contributor.author.fl_str_mv |
Barbosa, Raquel Guedes, Leonor Correia Cattoni, Maria Begoña Lobo, Patricia Pita Caldas, Ana Castro Fabbri, Margherita Bastos, Paulo Valadas, Anabela Carvalho, Herculano Albuquerque, Luisa Reimão, Sofia Ferreira, A. Gonçalves Ferreira, Joaquim J. Rosa, Mário Miguel Coelho, Miguel |
| dc.subject.por.fl_str_mv |
Deep brain stimulation Disability Milestones Mortality Parkinson's disease Subthalamic nucleus Neurology Geriatrics and Gerontology Clinical Neurology |
| topic |
Deep brain stimulation Disability Milestones Mortality Parkinson's disease Subthalamic nucleus Neurology Geriatrics and Gerontology Clinical Neurology |
| description |
Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship ( SFRH/BD/143797/2019 ) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Funding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT) through a Ph.D. Scholarship (SFRH/BD/143797/2019) and Prémio João Lobo Antunes by Santa Casa da Misericórdia de Lisboa. Publisher Copyright: © 2023 |
| publishDate |
2023 |
| dc.date.none.fl_str_mv |
2023-11-28T22:38:01Z 2024-01 2024-01-01T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
| format |
article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/160678 |
| url |
http://hdl.handle.net/10362/160678 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
1353-8020 PURE: 76898691 https://doi.org/10.1016/j.parkreldis.2023.105921 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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