Antifungal activity of phenolic compounds identified in flowers from the North Eastern Portugal against Candida species

• Main Author: Alves, Carlos
• Publication Date: 2014
• Other Authors: Ferreira, Isabel C. F. R., Barros, Lillian, Silva, Sónia Carina, Azeredo, Joana, Henriques, Mariana
• Format: Article
• Language: eng
• Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Download full: http://hdl.handle.net/1822/32115
• topic: antifungal effect; biofilms; Candida species; medicinal flowers; phenolic compounds; Science & Technology

Aim: To evaluate the antifungal effect of gallic acid, catechin, luteolin and quercetin, phenolic compounds identified from flowers of the North Eastern Portugal, against Candida planktonic and biofilm cells. Materials and Methods: The minimal inhibitory concentrations (MIC) were determined in Candida planktonic cells and the effect of phenolic compounds on Candida biofilms was assessed through quantification by colony forming units (CFUs). Results: MIC values demonstrated that gallic acid presented the highest effect against the all Candida species. Catechin showed a similar effect against C. albicans ATCC 90028cells. Additionally, gallic acid and quercetin had demonstrated only a minimum effect against Candida species biofilms. Conclusions: Gallic acid affected the growth of the different planktonic Candida species in all concentrations used, still catechin showed a similar effect against C. albicans ATCC 90028and C. glabrata ATCC 2001cells.Additionally, only gallic acid and quercetin demonstrated a slight effect against all Candida species biofilms.