VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels
Autor(a) principal: | |
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Data de Publicação: | 2005 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/2948 |
Resumo: | We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFR-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson’s chi-square ðw2Þ test and Fisher’s exact test (when no5). Threshold for significance was po0:05: Patient age ranged from 31 to 77 years (mean: 55 years). The VEGFR-3 immunoreactivity was as follows: 5 cases were negative (6.5%), 35+(45.4%), 27++ (35.1%), and 10+++ (13.0%). Reactions were positive for both lymphatic and blood vessels in several cases. VEGFR-3-positive reactions were more frequent in the tumor periphery than within the tumor. Immunoreactivity was also observed in myoepithelial cells surrounding both normal ducts and ducts with ductal carcinoma in situ. Statistical analysis of VEGFR-3 reactions was not significantly related to node status, microvessel density, and tumor grade. Ploidy showed a tendency towards significance (p=0.063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells. |
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VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vesselsLymphangiogenesisAngiogenesisVascular endothelial growth factor receptor 3Breast cancerScience & TechnologyWe examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFR-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson’s chi-square ðw2Þ test and Fisher’s exact test (when no5). Threshold for significance was po0:05: Patient age ranged from 31 to 77 years (mean: 55 years). The VEGFR-3 immunoreactivity was as follows: 5 cases were negative (6.5%), 35+(45.4%), 27++ (35.1%), and 10+++ (13.0%). Reactions were positive for both lymphatic and blood vessels in several cases. VEGFR-3-positive reactions were more frequent in the tumor periphery than within the tumor. Immunoreactivity was also observed in myoepithelial cells surrounding both normal ducts and ducts with ductal carcinoma in situ. Statistical analysis of VEGFR-3 reactions was not significantly related to node status, microvessel density, and tumor grade. Ploidy showed a tendency towards significance (p=0.063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells.ElsevierUniversidade do MinhoLongatto Filho, AdhemarMartins, AlbinoCosta, Sandra Maria Araújo daSchmitt, Fernando C.20052005-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/2948eng"Pathology : Research and Practice" . ISSN 0344-0338. 201:2 (2005) 93-99.0344-033810.1016/j.prp.2004.11.00815901129http://www.elsevier.com/wps/find/journaldescription.cws_home/701791/description#descriptioninfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:21:22Zoai:repositorium.sdum.uminho.pt:1822/2948Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T19:14:40.029093Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
title |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
spellingShingle |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels Longatto Filho, Adhemar Lymphangiogenesis Angiogenesis Vascular endothelial growth factor receptor 3 Breast cancer Science & Technology |
title_short |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
title_full |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
title_fullStr |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
title_full_unstemmed |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
title_sort |
VEGFR-3 expression in breast cancer tissue is not restricted to lymphatic vessels |
author |
Longatto Filho, Adhemar |
author_facet |
Longatto Filho, Adhemar Martins, Albino Costa, Sandra Maria Araújo da Schmitt, Fernando C. |
author_role |
author |
author2 |
Martins, Albino Costa, Sandra Maria Araújo da Schmitt, Fernando C. |
author2_role |
author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Longatto Filho, Adhemar Martins, Albino Costa, Sandra Maria Araújo da Schmitt, Fernando C. |
dc.subject.por.fl_str_mv |
Lymphangiogenesis Angiogenesis Vascular endothelial growth factor receptor 3 Breast cancer Science & Technology |
topic |
Lymphangiogenesis Angiogenesis Vascular endothelial growth factor receptor 3 Breast cancer Science & Technology |
description |
We examined the immunohistochemical reactivity for vascular endothelial growth factor receptor 3 (VEGFR-3), a protein playing an important role in lymphangiogenesis, in breast cancer. A retrospective series of 77 invasive ductal breast carcinomas was investigated. The relationship between VEGFR-3 expression and clinicopathologic parameters was examined for statistical significance using Pearson’s chi-square ðw2Þ test and Fisher’s exact test (when no5). Threshold for significance was po0:05: Patient age ranged from 31 to 77 years (mean: 55 years). The VEGFR-3 immunoreactivity was as follows: 5 cases were negative (6.5%), 35+(45.4%), 27++ (35.1%), and 10+++ (13.0%). Reactions were positive for both lymphatic and blood vessels in several cases. VEGFR-3-positive reactions were more frequent in the tumor periphery than within the tumor. Immunoreactivity was also observed in myoepithelial cells surrounding both normal ducts and ducts with ductal carcinoma in situ. Statistical analysis of VEGFR-3 reactions was not significantly related to node status, microvessel density, and tumor grade. Ploidy showed a tendency towards significance (p=0.063); however, owing to the limited number of cases, statistical significance was not reached. VEGFR-3 lacks lymphatic vessel specificity and is also expressed in blood vessels, myoepithelial cells, and neoplastic cells. |
publishDate |
2005 |
dc.date.none.fl_str_mv |
2005 2005-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/2948 |
url |
http://hdl.handle.net/1822/2948 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
"Pathology : Research and Practice" . ISSN 0344-0338. 201:2 (2005) 93-99. 0344-0338 10.1016/j.prp.2004.11.008 15901129 http://www.elsevier.com/wps/find/journaldescription.cws_home/701791/description#description |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132589220429824 |