HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium

Detalhes bibliográficos
Autor(a) principal: Santonen, Tiina
Data de Publicação: 2021
Outros Autores: Porras, Simo P., Bocca, Beatrice, Bousoumah, Radia, Duca, Radu Corneliu, Galea, Karen S., Godderis, Lode, Göen, Thomas, Hardy, Emilie, Iavicoli, Ivo, Janasik, Beata, Jones, Kate, Leese, Elizabeth, Leso, Veruscka, Louro, Henriqueta, Majery, Nicole, Ndaw, Sophie, Pinhal, Hermínia, Ruggieri, Flavia, Silva, Maria J., van Nieuwenhuyse, An, Verdonck, Jelle, Viegas, Susana, Wasowicz, Wojciech, Sepai, Ovnair, Scheepers, Paul T.J., Aimonen, Kukka, Antoine, Guillaume, Anzion, Rob, Burgart, Manuella, Castaño, Argelia, Cattaneo, Andrea, Cavallo, Domenico Maria, De Palma, Giuseppe, Denis, Flavien, Gambelunghe, Angela, Gomes, Bruno, Hanser, Ogier, Helenius, Riikka, Ladeira, Carina, López, Marta Esteban, Lovreglio, Piero, Marsan, Philippe, Melczer, Mathieu, Nogueira, Ana, Pletea, Elisabeta, Poels, Katrien, Remes, Jouko, Ribeiro, Edna, Santos, Sílvia Reis, Schaefers, Françoise, Spankie, Sally, Spoek, Robert, Rizki, Mohamed, Rousset, Davy, van Dael, Maurice, Veijalainen, Henna
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/13871
Resumo: Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating, and other surface treatment processes. The aim of this study was to provide EU-relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint, and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding, the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.
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spelling HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromiumHexavalent chromiumBiomonitoringOccupational exposureElectroplatingWeldingExposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating, and other surface treatment processes. The aim of this study was to provide EU-relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint, and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding, the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.ElsevierRCIPLSantonen, TiinaPorras, Simo P.Bocca, BeatriceBousoumah, RadiaDuca, Radu CorneliuGalea, Karen S.Godderis, LodeGöen, ThomasHardy, EmilieIavicoli, IvoJanasik, BeataJones, KateLeese, ElizabethLeso, VerusckaLouro, HenriquetaMajery, NicoleNdaw, SophiePinhal, HermíniaRuggieri, FlaviaSilva, Maria J.van Nieuwenhuyse, AnVerdonck, JelleViegas, SusanaWasowicz, WojciechSepai, OvnairScheepers, Paul T.J.Aimonen, KukkaAntoine, GuillaumeAnzion, RobBurgart, ManuellaCastaño, ArgeliaCattaneo, AndreaCavallo, Domenico MariaDe Palma, GiuseppeDenis, FlavienGambelunghe, AngelaGomes, BrunoHanser, OgierHelenius, RiikkaLadeira, CarinaLópez, Marta EstebanLovreglio, PieroMarsan, PhilippeMelczer, MathieuNogueira, AnaPletea, ElisabetaPoels, KatrienRemes, JoukoRibeiro, EdnaSantos, Sílvia ReisSchaefers, FrançoiseSpankie, SallySpoek, RobertRizki, MohamedRousset, Davyvan Dael, MauriceVeijalainen, Henna2021-10-12T11:55:53Z2022-032022-03-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/13871engSantonen T, Porras SP, Bocca B, Bousoumah R, Duca RC, Viegas S, et al. HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium. Environ Res. 2022;204(Part A):111984.10.1016/j.envres.2021.111984info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:09:17Zoai:repositorio.ipl.pt:10400.21/13871Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:21:44.877401Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
spellingShingle HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
Santonen, Tiina
Hexavalent chromium
Biomonitoring
Occupational exposure
Electroplating
Welding
title_short HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_full HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_fullStr HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_full_unstemmed HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
title_sort HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium
author Santonen, Tiina
author_facet Santonen, Tiina
Porras, Simo P.
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S.
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J.
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T.J.
Aimonen, Kukka
Antoine, Guillaume
Anzion, Rob
Burgart, Manuella
Castaño, Argelia
Cattaneo, Andrea
Cavallo, Domenico Maria
De Palma, Giuseppe
Denis, Flavien
Gambelunghe, Angela
Gomes, Bruno
Hanser, Ogier
Helenius, Riikka
Ladeira, Carina
López, Marta Esteban
Lovreglio, Piero
Marsan, Philippe
Melczer, Mathieu
Nogueira, Ana
Pletea, Elisabeta
Poels, Katrien
Remes, Jouko
Ribeiro, Edna
Santos, Sílvia Reis
Schaefers, Françoise
Spankie, Sally
Spoek, Robert
Rizki, Mohamed
Rousset, Davy
van Dael, Maurice
Veijalainen, Henna
author_role author
author2 Porras, Simo P.
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S.
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J.
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T.J.
Aimonen, Kukka
Antoine, Guillaume
Anzion, Rob
Burgart, Manuella
Castaño, Argelia
Cattaneo, Andrea
Cavallo, Domenico Maria
De Palma, Giuseppe
Denis, Flavien
Gambelunghe, Angela
Gomes, Bruno
Hanser, Ogier
Helenius, Riikka
Ladeira, Carina
López, Marta Esteban
Lovreglio, Piero
Marsan, Philippe
Melczer, Mathieu
Nogueira, Ana
Pletea, Elisabeta
Poels, Katrien
Remes, Jouko
Ribeiro, Edna
Santos, Sílvia Reis
Schaefers, Françoise
Spankie, Sally
Spoek, Robert
Rizki, Mohamed
Rousset, Davy
van Dael, Maurice
Veijalainen, Henna
author2_role author
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author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
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author
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author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Santonen, Tiina
Porras, Simo P.
Bocca, Beatrice
Bousoumah, Radia
Duca, Radu Corneliu
Galea, Karen S.
Godderis, Lode
Göen, Thomas
Hardy, Emilie
Iavicoli, Ivo
Janasik, Beata
Jones, Kate
Leese, Elizabeth
Leso, Veruscka
Louro, Henriqueta
Majery, Nicole
Ndaw, Sophie
Pinhal, Hermínia
Ruggieri, Flavia
Silva, Maria J.
van Nieuwenhuyse, An
Verdonck, Jelle
Viegas, Susana
Wasowicz, Wojciech
Sepai, Ovnair
Scheepers, Paul T.J.
Aimonen, Kukka
Antoine, Guillaume
Anzion, Rob
Burgart, Manuella
Castaño, Argelia
Cattaneo, Andrea
Cavallo, Domenico Maria
De Palma, Giuseppe
Denis, Flavien
Gambelunghe, Angela
Gomes, Bruno
Hanser, Ogier
Helenius, Riikka
Ladeira, Carina
López, Marta Esteban
Lovreglio, Piero
Marsan, Philippe
Melczer, Mathieu
Nogueira, Ana
Pletea, Elisabeta
Poels, Katrien
Remes, Jouko
Ribeiro, Edna
Santos, Sílvia Reis
Schaefers, Françoise
Spankie, Sally
Spoek, Robert
Rizki, Mohamed
Rousset, Davy
van Dael, Maurice
Veijalainen, Henna
dc.subject.por.fl_str_mv Hexavalent chromium
Biomonitoring
Occupational exposure
Electroplating
Welding
topic Hexavalent chromium
Biomonitoring
Occupational exposure
Electroplating
Welding
description Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating, and other surface treatment processes. The aim of this study was to provide EU-relevant data on occupational Cr(VI) exposure to support the regulatory risk assessment and decision-making. In addition, the capability and validity of different biomarkers for the assessment of Cr(VI) exposure were evaluated. The study involved nine European countries and involved 399 workers in different industry sectors with exposures to Cr(VI) such as welding, bath plating, applying or removing paint, and other tasks. We also studied 203 controls to establish a background in workers with no direct exposure to Cr(VI). We applied a cross-sectional study design and used chromium in urine as the primary biomonitoring method for Cr(VI) exposure. Additionally, we studied the use of red blood cells (RBC) and exhaled breath condensate (EBC) for biomonitoring of exposure to Cr(VI). Personal measurements were used to study exposure to inhalable and respirable Cr(VI) by personal air sampling. Dermal exposure was studied by taking hand wipe samples. The highest internal exposures were observed in the use of Cr(VI) in electrolytic bath plating. In stainless steel welding, the internal Cr exposure was clearly lower when compared to plating activities. We observed a high correlation between chromium urinary levels and air Cr(VI) or dermal total Cr exposure. Urinary chromium showed its value as a first approach for the assessment of total, internal exposure. Correlations between urinary chromium and Cr(VI) in EBC and Cr in RBC were low, probably due to differences in kinetics and indicating that these biomonitoring approaches may not be interchangeable but rather complementary. This study showed that occupational biomonitoring studies can be conducted successfully by multi-national collaboration and provide relevant information to support policy actions aiming to reduce occupational exposure to chemicals.
publishDate 2021
dc.date.none.fl_str_mv 2021-10-12T11:55:53Z
2022-03
2022-03-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/13871
url http://hdl.handle.net/10400.21/13871
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Santonen T, Porras SP, Bocca B, Bousoumah R, Duca RC, Viegas S, et al. HBM4EU chromates study: overall results and recommendations for the biomonitoring of occupational exposure to hexavalent chromium. Environ Res. 2022;204(Part A):111984.
10.1016/j.envres.2021.111984
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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