Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2022 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10362/148019 |
Resumo: | Funding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
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Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal ParasitesBinary Longitudinal Models with Temporal Structure in a Four-Arm Randomized TrialanemiaAngoladewormingintestinal parasiteslongitudinalmalnutritionmild-to-severemoderate-to-severestuntingtest-and-treatwastingRA0421 Public health. Hygiene. Preventive MedicineQR MicrobiologyFood ScienceNutrition and DieteticsGastroenterologyInfectious DiseasesPediatrics, Perinatology, and Child HealthParasitologyGeneral Immunology and MicrobiologySDG 3 - Good Health and Well-beingSDG 1 - No PovertySDG 10 - Reduced InequalitiesSDG 9 - Industry, Innovation, and InfrastructureSDG 2 - Zero HungerFunding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Undernutrition, anemia, and intestinal parasitic infections are public health problems in Angola, especially in pre-school children. We analyzed binary data from a longitudinal four-arm randomized parallel trial conducted in Bengo Province, northern Angola, over the course of two years, with seven follow-up assessments to explore the effects of four interventions (deworming and a test-and-treat approach for intestinal parasites, at both the individual and household levels) on wasting and stunting, and to understand their indirect benefits for anemia, malaria, diarrhea, and vomiting. A total of 121 children with intestinal parasitic infections received baseline treatment, and were allocated to the four arms (1:1:1:1). Using continuous outcome variables of height-for-age (HAZ) and weight-for-height (WHZ) statistical approaches did not reveal a clear benefit of any particular arm (Pathogens 2021, 10, 309). Next, HAZ and WHZ were transformed into binary variables of stunting and wasting, respectively, considering their mild-to-severe (Z-score < −1) and moderate-to-severe degrees (Z-score < −2). Original clinical data (on anemia, diarrhea, vomiting, and malaria) were also analyzed. From a binary longitudinal analysis with different dependence structures, using the R package bild, fitted models revealed the potential benefit of a test-and-treat approach at the individual level for wasting compared with annual albendazole at the individual level, especially considering mild-to-severe forms (ORadj = 0.27; p = 0.007). All arms showed similar effects on stunting, compared with annual albendazole, at a 5% significance level. Time and age at baseline presented favorable effects in the percentage of stunting using both severity degrees. Results showed a decreased chance of having anemia and diarrhea over time, although with no significant differences between arms. Data from longitudinal studies are essential to study the direct and indirect effects of interventions, such as deworming, and to explore additional approaches aiming at better understanding the temporal structure of nutrition and health outcomes in children.Population health, policies and services (PPS)Global Health and Tropical Medicine (GHTM)Instituto de Higiene e Medicina Tropical (IHMT)Universidade NOVA de LisboaRUNGasparinho, CarolinaGonçalves, Maria HelenaChissaque, AssucênioSilva, Giovani L.Fortes, FilomenoGonçalves, Luzia2023-01-23T22:15:53Z2022-06-012022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/148019eng1422-8599PURE: 50841983https://doi.org/10.3390/nu14112185info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:29:17Zoai:run.unl.pt:10362/148019Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:53:09.238428Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites Binary Longitudinal Models with Temporal Structure in a Four-Arm Randomized Trial |
| title |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| spellingShingle |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites Gasparinho, Carolina anemia Angola deworming intestinal parasites longitudinal malnutrition mild-to-severe moderate-to-severe stunting test-and-treat wasting RA0421 Public health. Hygiene. Preventive Medicine QR Microbiology Food Science Nutrition and Dietetics Gastroenterology Infectious Diseases Pediatrics, Perinatology, and Child Health Parasitology General Immunology and Microbiology SDG 3 - Good Health and Well-being SDG 1 - No Poverty SDG 10 - Reduced Inequalities SDG 9 - Industry, Innovation, and Infrastructure SDG 2 - Zero Hunger |
| title_short |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| title_full |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| title_fullStr |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| title_full_unstemmed |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| title_sort |
Wasting, Stunting, and Anemia in Angolan Children after Deworming with Albendazole or a Test-and-Treat Approach for Intestinal Parasites |
| author |
Gasparinho, Carolina |
| author_facet |
Gasparinho, Carolina Gonçalves, Maria Helena Chissaque, Assucênio Silva, Giovani L. Fortes, Filomeno Gonçalves, Luzia |
| author_role |
author |
| author2 |
Gonçalves, Maria Helena Chissaque, Assucênio Silva, Giovani L. Fortes, Filomeno Gonçalves, Luzia |
| author2_role |
author author author author author |
| dc.contributor.none.fl_str_mv |
Population health, policies and services (PPS) Global Health and Tropical Medicine (GHTM) Instituto de Higiene e Medicina Tropical (IHMT) Universidade NOVA de Lisboa RUN |
| dc.contributor.author.fl_str_mv |
Gasparinho, Carolina Gonçalves, Maria Helena Chissaque, Assucênio Silva, Giovani L. Fortes, Filomeno Gonçalves, Luzia |
| dc.subject.por.fl_str_mv |
anemia Angola deworming intestinal parasites longitudinal malnutrition mild-to-severe moderate-to-severe stunting test-and-treat wasting RA0421 Public health. Hygiene. Preventive Medicine QR Microbiology Food Science Nutrition and Dietetics Gastroenterology Infectious Diseases Pediatrics, Perinatology, and Child Health Parasitology General Immunology and Microbiology SDG 3 - Good Health and Well-being SDG 1 - No Poverty SDG 10 - Reduced Inequalities SDG 9 - Industry, Innovation, and Infrastructure SDG 2 - Zero Hunger |
| topic |
anemia Angola deworming intestinal parasites longitudinal malnutrition mild-to-severe moderate-to-severe stunting test-and-treat wasting RA0421 Public health. Hygiene. Preventive Medicine QR Microbiology Food Science Nutrition and Dietetics Gastroenterology Infectious Diseases Pediatrics, Perinatology, and Child Health Parasitology General Immunology and Microbiology SDG 3 - Good Health and Well-being SDG 1 - No Poverty SDG 10 - Reduced Inequalities SDG 9 - Industry, Innovation, and Infrastructure SDG 2 - Zero Hunger |
| description |
Funding Information: Funding: This work was supported by the promoters of CISA (Camões, Institute of Cooperation and Language, Portugal; Calouste Gulbenkian Foundation (FCG); Government of Bengo Province; Angolan Ministry of Health—MINSA) and the National Malaria Control Program, Angola; the Foundation for Science and Technology (FCT, grants reference SFRH/BD/91566/2012, UIDB/00006/2020, UIDP/00006/2020, and UID/04413/2020); and the FCG (grant number 212008), Lisbon, Portugal. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland. |
| publishDate |
2022 |
| dc.date.none.fl_str_mv |
2022-06-01 2022-06-01T00:00:00Z 2023-01-23T22:15:53Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10362/148019 |
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http://hdl.handle.net/10362/148019 |
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eng |
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eng |
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1422-8599 PURE: 50841983 https://doi.org/10.3390/nu14112185 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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