Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players

Detalhes bibliográficos
Autor(a) principal: Silva, Hugo Henrique
Data de Publicação: 2023
Outros Autores: Tavares, Valéria, Silva, Maria Raquel G., Neto, Beatriz Vieira, Cerqueira, Fátima, Medeiros, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10362/155489
Resumo: Funding Information: This research was supported by research found at ICBAS-PD Biomedical Sciences-200203100 and the Portuguese League Against Cancer—Northern Branch (LPCC-NRN). Funding Information: We would like to thank all the volleyball players who participated in this study and the coaches for their collaboration. We would also like to thank the Instituto Português de Oncologia do Porto (IPOP), the Fundação para a Ciência e Tecnologia (FCT), and the Faculty of Health Sciences—University Fernando Pessoa, Porto. V.T. is a PhD scholarship holder (2020.08969.BD) supported by Fundação para a Ciência e Tecnologia (FCT), and co-financed by European Social Funds (FSE) and national funds of MCTES. Publisher Copyright: © 2023 by the authors.
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spelling Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball PlayersFAAHgenehigh-level performancepolymorphismvolleyballGeneticsGenetics(clinical)Funding Information: This research was supported by research found at ICBAS-PD Biomedical Sciences-200203100 and the Portuguese League Against Cancer—Northern Branch (LPCC-NRN). Funding Information: We would like to thank all the volleyball players who participated in this study and the coaches for their collaboration. We would also like to thank the Instituto Português de Oncologia do Porto (IPOP), the Fundação para a Ciência e Tecnologia (FCT), and the Faculty of Health Sciences—University Fernando Pessoa, Porto. V.T. is a PhD scholarship holder (2020.08969.BD) supported by Fundação para a Ciência e Tecnologia (FCT), and co-financed by European Social Funds (FSE) and national funds of MCTES. Publisher Copyright: © 2023 by the authors.Genetic variants are recognized to affect athletic performance, partially by modulating competition-facilitating behavior. In this study, the role of three genetic variants previously linked to athlete status was investigated among elite volleyball players. A total of 228 players (26.7 ± 8.1 years old) participating in the Portuguese championship and with multiple medalists in national and international competitions were evaluated in terms of anthropometrics, training regime, sports experience, and a history of sports lesions. SNP genotyping was conducted by means of TaqMan® Allelic Discrimination Methodology. Volleyball players showed significantly different anthropometric indicators and training habits according to sex (p < 0.05). The A allele of the genetic variant Fatty Acid Amide Hydrolase (FAAH) rs324420 (C385A) was shown to be significantly associated with superior athletic achievements under a dominant genetic model (AA/AC vs. CC, odds ratio (OR) = 1.70; 95% Cl, 0.93–3.13; p = 0.026; p < 0.001 after Bootstrap), which was corroborated by a multivariable analysis (AA/AC vs. CC adjusted OR = 2.00; 95% Cl, 1.04–3.82; p = 0.037). Age and hand length were also found to be independently associated with high-level performance (p < 0.05). Our results confirm the role of FAAH in athletic performance. More investigation into this polymorphism’s potential impact on stress coping, pain, and inflammation regulation in sport, particularly in the scope of lesions prevention and treatment, is required.NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)Comprehensive Health Research Centre (CHRC) - pólo NMSRUNSilva, Hugo HenriqueTavares, ValériaSilva, Maria Raquel G.Neto, Beatriz VieiraCerqueira, FátimaMedeiros, Rui2023-07-18T22:15:55Z2023-062023-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10362/155489eng0920-8569PURE: 66647194https://doi.org/10.3390/genes14061164info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T05:38:04Zoai:run.unl.pt:10362/155489Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:56:05.533330Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
title Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
spellingShingle Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
Silva, Hugo Henrique
FAAH
gene
high-level performance
polymorphism
volleyball
Genetics
Genetics(clinical)
title_short Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
title_full Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
title_fullStr Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
title_full_unstemmed Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
title_sort Association of FAAH rs324420 (C385A) Polymorphism with High-Level Performance in Volleyball Players
author Silva, Hugo Henrique
author_facet Silva, Hugo Henrique
Tavares, Valéria
Silva, Maria Raquel G.
Neto, Beatriz Vieira
Cerqueira, Fátima
Medeiros, Rui
author_role author
author2 Tavares, Valéria
Silva, Maria Raquel G.
Neto, Beatriz Vieira
Cerqueira, Fátima
Medeiros, Rui
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv NOVA Medical School|Faculdade de Ciências Médicas (NMS|FCM)
Comprehensive Health Research Centre (CHRC) - pólo NMS
RUN
dc.contributor.author.fl_str_mv Silva, Hugo Henrique
Tavares, Valéria
Silva, Maria Raquel G.
Neto, Beatriz Vieira
Cerqueira, Fátima
Medeiros, Rui
dc.subject.por.fl_str_mv FAAH
gene
high-level performance
polymorphism
volleyball
Genetics
Genetics(clinical)
topic FAAH
gene
high-level performance
polymorphism
volleyball
Genetics
Genetics(clinical)
description Funding Information: This research was supported by research found at ICBAS-PD Biomedical Sciences-200203100 and the Portuguese League Against Cancer—Northern Branch (LPCC-NRN). Funding Information: We would like to thank all the volleyball players who participated in this study and the coaches for their collaboration. We would also like to thank the Instituto Português de Oncologia do Porto (IPOP), the Fundação para a Ciência e Tecnologia (FCT), and the Faculty of Health Sciences—University Fernando Pessoa, Porto. V.T. is a PhD scholarship holder (2020.08969.BD) supported by Fundação para a Ciência e Tecnologia (FCT), and co-financed by European Social Funds (FSE) and national funds of MCTES. Publisher Copyright: © 2023 by the authors.
publishDate 2023
dc.date.none.fl_str_mv 2023-07-18T22:15:55Z
2023-06
2023-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/155489
url http://hdl.handle.net/10362/155489
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 0920-8569
PURE: 66647194
https://doi.org/10.3390/genes14061164
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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