Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/1822/56615 |
Resumo: | Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy. |
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Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcuminmagnesium ferrite nanoparticlesmagnetoliposomescurcuminsuperparamagnetismpegylationcancer therapyCiências Naturais::Ciências QuímicasScience & TechnologyMagnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy.This work was supported by the Portuguese Foundation for Science and Technology (FCT) in the framework of the Strategic Funding of CF-UM-UP (UID/FIS/04650/2013). FCT, POPH-QREN and FSE are acknowledged for the PhD grant of A. R. O. Rodrigues (SFRH/BD/90949/2012).MAP-Fis PhD Program.info:eu-repo/semantics/publishedVersionRoyal SocietyUniversidade do MinhoCardoso, Beatriz D.Rio, Irina S. R.Rodrigues, Ana Rita OliveiraFernandes, Francisca C. T.Almeida, B. G.Pires, A.Pereira, A. M.Araújo, J. P.Castanheira, Elisabete M. S.Coutinho, Paulo J. G.2018-102018-10-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/1822/56615engB. D. Cardoso, I. S. R. Rio, A. R. O. Rodrigues, F. C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, E. M. S. Castanheira, P. J. G. Coutinho, Royal Society Open Science, 5 (10) (2018) 1810172054-570310.1098/rsos.181017http://rsos.royalsocietypublishing.org/content/5/10/181017info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:47:03ZPortal AgregadorONG |
dc.title.none.fl_str_mv |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
title |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
spellingShingle |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin Cardoso, Beatriz D. magnesium ferrite nanoparticles magnetoliposomes curcumin superparamagnetism pegylation cancer therapy Ciências Naturais::Ciências Químicas Science & Technology |
title_short |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
title_full |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
title_fullStr |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
title_full_unstemmed |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
title_sort |
Magnetoliposomes containing magnesium ferrite nanoparticles as nanocarriers for the mode drug curcumin |
author |
Cardoso, Beatriz D. |
author_facet |
Cardoso, Beatriz D. Rio, Irina S. R. Rodrigues, Ana Rita Oliveira Fernandes, Francisca C. T. Almeida, B. G. Pires, A. Pereira, A. M. Araújo, J. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
author_role |
author |
author2 |
Rio, Irina S. R. Rodrigues, Ana Rita Oliveira Fernandes, Francisca C. T. Almeida, B. G. Pires, A. Pereira, A. M. Araújo, J. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade do Minho |
dc.contributor.author.fl_str_mv |
Cardoso, Beatriz D. Rio, Irina S. R. Rodrigues, Ana Rita Oliveira Fernandes, Francisca C. T. Almeida, B. G. Pires, A. Pereira, A. M. Araújo, J. P. Castanheira, Elisabete M. S. Coutinho, Paulo J. G. |
dc.subject.por.fl_str_mv |
magnesium ferrite nanoparticles magnetoliposomes curcumin superparamagnetism pegylation cancer therapy Ciências Naturais::Ciências Químicas Science & Technology |
topic |
magnesium ferrite nanoparticles magnetoliposomes curcumin superparamagnetism pegylation cancer therapy Ciências Naturais::Ciências Químicas Science & Technology |
description |
Magnesium ferrite nanoparticles, with diameters around 25 nm, were synthesized by coprecipitation method. The magnetic properties indicate a superparamagnetic behavior, with a maximum magnetization of 16.2 emu/g, a coercive field of 22.1 Oe and a blocking temperature of 183.2 K. These MgFe2O4 nanoparticles were used to produce aqueous and solid magnetoliposomes, with sizes below 130 nm. The potential drug curcumin was successfully incorporated in these nanosystems, with high encapsulation efficiencies (above 89%). Interaction by fusion between both types of drug loaded magnetoliposomes (with or without PEGylation) and models of biological membranes was demonstrated, using FRET or fluorescence quenching assays. These results point to future applications of magnetoliposomes containing MgFe2O4 nanoparticles in cancer therapy, allowing combined magnetic hyperthermia and chemotherapy. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-10 2018-10-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/56615 |
url |
http://hdl.handle.net/1822/56615 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
B. D. Cardoso, I. S. R. Rio, A. R. O. Rodrigues, F. C. T. Fernandes, B. G. Almeida, A. Pires, A. M. Pereira, J. P. Araújo, E. M. S. Castanheira, P. J. G. Coutinho, Royal Society Open Science, 5 (10) (2018) 181017 2054-5703 10.1098/rsos.181017 http://rsos.royalsocietypublishing.org/content/5/10/181017 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Royal Society |
publisher.none.fl_str_mv |
Royal Society |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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