Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds

Detalhes bibliográficos
Autor(a) principal: Pinho, Eva
Data de Publicação: 2014
Outros Autores: Ferreira, Isabel C. F. R., Barros, Lillian, Carvalho, Ana Maria, Soares, Graça M. B., Henriques, Mariana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/1822/31888
Resumo: The present work aims to assess the antibacterial potential of phenolic extracts, recovered from plants obtained on the North East of Portugal, and of their phenolic compounds (ellagic, caffeic, and gallic acids, quercetin, kaempferol, and rutin), against bacteria commonly found on skin infections. The disk diffusion and the susceptibility assays were used to identify the most active extracts and phenolic compounds. The effect of selected phenolic compounds on animal cells was assessed by determination of cellular metabolic activity. Gallic acid had a higher activity, against gram-positive (S. epidermidis and S. aureus) and gram-negative bacteria (K. pneumoniae) at lower concentrations, than the other compounds. The caffeic acid, also, showed good antibacterial activity against the 3 bacteria used. The gallic acid was effective against the 3 bacteria without causing harm to the animal cells. Gallic and caffeic acid showed a promising applicability as antibacterial agents for the treatment of infected wounds.
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spelling Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compoundsScience & TechnologyThe present work aims to assess the antibacterial potential of phenolic extracts, recovered from plants obtained on the North East of Portugal, and of their phenolic compounds (ellagic, caffeic, and gallic acids, quercetin, kaempferol, and rutin), against bacteria commonly found on skin infections. The disk diffusion and the susceptibility assays were used to identify the most active extracts and phenolic compounds. The effect of selected phenolic compounds on animal cells was assessed by determination of cellular metabolic activity. Gallic acid had a higher activity, against gram-positive (S. epidermidis and S. aureus) and gram-negative bacteria (K. pneumoniae) at lower concentrations, than the other compounds. The caffeic acid, also, showed good antibacterial activity against the 3 bacteria used. The gallic acid was effective against the 3 bacteria without causing harm to the animal cells. Gallic and caffeic acid showed a promising applicability as antibacterial agents for the treatment of infected wounds.The authors thank the Foundation for Science and Technology (Portugal) for financial support by the E. Pinho grant (SFRH/BD/62665/2009) and L. Barros grant (SFRH/BPD/4609/2000), and by the projects PEst-OE/EQB/LA0023/2013, PEst-C/CTM/UI0264/2011, and PEst-OE/EQB/LA0023/2013. Also, the authors acknowledge the financial support from FEDER through Programa Operacional Factores de Competitividade-COMPETE and to COMPETE/QREN/EU (CIMO strategic project 19 PEst-OE/AGR/UI0690/2011), and through the Project "BioHealth-Biotechnology and Bioengineering approaches to improve health quality", Ref. NORTE-07-0124-FEDER-000027, co-funded by the Programa Operacional Regional do Norte (ON.2-O Novo Norte), QREN, FEDER. The authors also acknowledge the project "Consolidating Research Expertise and Resources on Cellular and Molecular Biotechnology at CEB/IBB", Ref. FCOMP-01-0124-FEDER-027462.Hindawi Publishing CorporationUniversidade do MinhoPinho, EvaFerreira, Isabel C. F. R.Barros, LillianCarvalho, Ana MariaSoares, Graça M. B.Henriques, Mariana20142014-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/31888engPinho, Eva; Ferreira, I.C.F.R.; Barros, L.; Carvalho, A.M.; Soares, G.M.B.; Henriques, M. Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds BioMed Research International 2014(814590) 1-8, 2014.2314-61332314-614110.1155/2014/81459024804249http://www.hindawi.com/journals/bmri/info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:42:49ZPortal AgregadorONG
dc.title.none.fl_str_mv Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
title Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
spellingShingle Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
Pinho, Eva
Science & Technology
title_short Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
title_full Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
title_fullStr Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
title_full_unstemmed Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
title_sort Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds
author Pinho, Eva
author_facet Pinho, Eva
Ferreira, Isabel C. F. R.
Barros, Lillian
Carvalho, Ana Maria
Soares, Graça M. B.
Henriques, Mariana
author_role author
author2 Ferreira, Isabel C. F. R.
Barros, Lillian
Carvalho, Ana Maria
Soares, Graça M. B.
Henriques, Mariana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade do Minho
dc.contributor.author.fl_str_mv Pinho, Eva
Ferreira, Isabel C. F. R.
Barros, Lillian
Carvalho, Ana Maria
Soares, Graça M. B.
Henriques, Mariana
dc.subject.por.fl_str_mv Science & Technology
topic Science & Technology
description The present work aims to assess the antibacterial potential of phenolic extracts, recovered from plants obtained on the North East of Portugal, and of their phenolic compounds (ellagic, caffeic, and gallic acids, quercetin, kaempferol, and rutin), against bacteria commonly found on skin infections. The disk diffusion and the susceptibility assays were used to identify the most active extracts and phenolic compounds. The effect of selected phenolic compounds on animal cells was assessed by determination of cellular metabolic activity. Gallic acid had a higher activity, against gram-positive (S. epidermidis and S. aureus) and gram-negative bacteria (K. pneumoniae) at lower concentrations, than the other compounds. The caffeic acid, also, showed good antibacterial activity against the 3 bacteria used. The gallic acid was effective against the 3 bacteria without causing harm to the animal cells. Gallic and caffeic acid showed a promising applicability as antibacterial agents for the treatment of infected wounds.
publishDate 2014
dc.date.none.fl_str_mv 2014
2014-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/1822/31888
url http://hdl.handle.net/1822/31888
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Pinho, Eva; Ferreira, I.C.F.R.; Barros, L.; Carvalho, A.M.; Soares, G.M.B.; Henriques, M. Antibacterial potential of northeastern Portugal wild plant extracts and respective phenolic compounds BioMed Research International 2014(814590) 1-8, 2014.
2314-6133
2314-6141
10.1155/2014/814590
24804249
http://www.hindawi.com/journals/bmri/
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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