Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis

Detalhes bibliográficos
Autor(a) principal: Silva, Inês
Data de Publicação: 2022
Outros Autores: Mendes, Priscila, Guerra, Sofia, Pinto, Rui, Mateus, Vanessa
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14941
Resumo: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitisTNBS-induced colitisAnti-inflammatory effectExperimental colitis modelInflammatory bowel diseaseTopiramateFCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Inflammatory bowel disease (IBD) is characterized by a chronic and relapsing inflammatory response in the gastrointestinal tract, resulting in severe symptoms such as abdominal pain, vomiting, diarrhea, bloody stools, and weight loss. Currently, there is no cure, and the pharmacological treatment includes drugs that induce and keep the patient in remission, not reversing the underlying pathogenic mechanism. In the long term, these therapies may cause various side effects and complications, which has increased the need to investigate new, more effective, and safer pharmacological approaches. In preclinical studies, topiramate has demonstrated a potential anti-inflammatory effect by inhibiting the production of several pro-inflammatory cytokines. This study aimed to investigate the effect of topiramate in a chronic TNBS-induced colitis model in rodents. Experimental colitis was induced by four intrarectal administrations of 1% TNBS in female CD-1 mice. Topiramate 10 and 20 mg were administered intraperitoneally for 14 days. Several parameters were evaluated, such as body weight, alkaline phosphatase (ALP), fecal hemoglobin, fecal calprotectin, tumor necrosis factor (TNF)-α, and interleukin (IL)-10. Topiramate reduces TNBS-induced colonic damage in a model of chronic experimental colitis and normalizes stool consistency and anus appearance. Additionally, topiramate significantly reduced the concentration of ALP, fecal hemoglobin, fecal calprotectin, TNF-α, and IL-10, demonstrating it to be a promising pharmacological approach for treating IBD in the future.MDPIRCIPLSilva, InêsMendes, PriscilaGuerra, SofiaPinto, RuiMateus, Vanessa2022-08-29T10:33:49Z2022-082022-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14941engSilva I, Mendes P, Guerra S, Pinto R, Mateus V. Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis. Int J Mol Sci. 2022;23(16):9127.10.3390/ijms23169127info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:46Zoai:repositorio.ipl.pt:10400.21/14941Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:39.556652Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
title Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
spellingShingle Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
Silva, Inês
TNBS-induced colitis
Anti-inflammatory effect
Experimental colitis model
Inflammatory bowel disease
Topiramate
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
title_full Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
title_fullStr Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
title_full_unstemmed Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
title_sort Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis
author Silva, Inês
author_facet Silva, Inês
Mendes, Priscila
Guerra, Sofia
Pinto, Rui
Mateus, Vanessa
author_role author
author2 Mendes, Priscila
Guerra, Sofia
Pinto, Rui
Mateus, Vanessa
author2_role author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Silva, Inês
Mendes, Priscila
Guerra, Sofia
Pinto, Rui
Mateus, Vanessa
dc.subject.por.fl_str_mv TNBS-induced colitis
Anti-inflammatory effect
Experimental colitis model
Inflammatory bowel disease
Topiramate
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic TNBS-induced colitis
Anti-inflammatory effect
Experimental colitis model
Inflammatory bowel disease
Topiramate
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-08-29T10:33:49Z
2022-08
2022-08-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14941
url http://hdl.handle.net/10400.21/14941
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Silva I, Mendes P, Guerra S, Pinto R, Mateus V. Anti-inflammatory effect of topiramate in a chronic model of TNBS-induced colitis. Int J Mol Sci. 2022;23(16):9127.
10.3390/ijms23169127
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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