Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice

Detalhes bibliográficos
Autor(a) principal: Mateus, Vanessa
Data de Publicação: 2022
Outros Autores: Estarreja, João, Silva, Inês, Gonçalves, Fernando, Teixeira-Lemos, Edite, Pinto, Rui
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.21/14714
Resumo: FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
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spelling Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in miceInflammatory bowel diseasePolyphenolsRed wineColitisInflammationTNBS-induced colitisFCT_UIDB/05608/2020FCT_UIDP/05608/2020FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.Background: Inflammatory bowel disease (IBD) is a chronic relapsing inflammatory disorder represented by Crohn’s disease and ulcerative colitis. Currently, there is no cure and pharmacological treatment aims to induce and maintain remission in patients. Because the therapy reveals relatively high toxicity, during a long-term utilization, it is essential to investigate new pharmacological approaches. Polyphenols, commonly present in red wine, have shown health-beneficial effects related to their antioxidant and anti-inflammatory effects through the inhibition of NF-kB activation, COX-2, and iNOS induction. In this sense, it would be interesting to study their effects in an IBD context. Therefore, this study aims to evaluate the effects of an aqueous extract of phenolic compounds in a 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced model of colitis. Method: Experimental colitis was induced in mice through an intrarectal administration of TNBS and then the mice were treated with an aqueous extract of phenolic compounds intraperitoneally for four days. Results and Discussion: The extract demonstrated an anti-inflammatory effect, reduced TNF-α levels in the colon, and had a beneficial effect on the extraintestinal manifestations related to IBD, without any significant side effects. The extract of phenolic compounds demonstrated to be a valuable object of study for the management of IBD in the future.MDPIRCIPLMateus, VanessaEstarreja, JoãoSilva, InêsGonçalves, FernandoTeixeira-Lemos, EditePinto, Rui2022-06-20T14:10:17Z2022-062022-06-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.21/14714engMateus V, Estarreja J, Silva I, Gonçalves F, Teixeira-Lemos E, Pinto R. Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice. Curr Issues Mol Biol. 2022;44(6):2745-58.10.3390/cimb44060188info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-08-03T10:11:16Zoai:repositorio.ipl.pt:10400.21/14714Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:22:28.370620Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
title Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
spellingShingle Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
Mateus, Vanessa
Inflammatory bowel disease
Polyphenols
Red wine
Colitis
Inflammation
TNBS-induced colitis
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
title_short Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
title_full Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
title_fullStr Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
title_full_unstemmed Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
title_sort Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice
author Mateus, Vanessa
author_facet Mateus, Vanessa
Estarreja, João
Silva, Inês
Gonçalves, Fernando
Teixeira-Lemos, Edite
Pinto, Rui
author_role author
author2 Estarreja, João
Silva, Inês
Gonçalves, Fernando
Teixeira-Lemos, Edite
Pinto, Rui
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv RCIPL
dc.contributor.author.fl_str_mv Mateus, Vanessa
Estarreja, João
Silva, Inês
Gonçalves, Fernando
Teixeira-Lemos, Edite
Pinto, Rui
dc.subject.por.fl_str_mv Inflammatory bowel disease
Polyphenols
Red wine
Colitis
Inflammation
TNBS-induced colitis
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
topic Inflammatory bowel disease
Polyphenols
Red wine
Colitis
Inflammation
TNBS-induced colitis
FCT_UIDB/05608/2020
FCT_UIDP/05608/2020
description FCT_UIDB/05608/2020. FCT_UIDP/05608/2020.
publishDate 2022
dc.date.none.fl_str_mv 2022-06-20T14:10:17Z
2022-06
2022-06-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.21/14714
url http://hdl.handle.net/10400.21/14714
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Mateus V, Estarreja J, Silva I, Gonçalves F, Teixeira-Lemos E, Pinto R. Effect of aqueous extract of phenolic compounds obtained from red wine in experimental model of colitis in mice. Curr Issues Mol Biol. 2022;44(6):2745-58.
10.3390/cimb44060188
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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