Recent insights into mitochondrial targeting strategies in liver transplantation

• Main Author: Martins, Rui Miguel
• Publication Date: 2018
• Other Authors: Teodoro, João Soeiro, Furtado, Emanuel, Rolo, Anabela Pinto, Palmeira, Carlos Marques, Tralhão, José Guilherme
• Format: Article
• Language: eng
• Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Download full: http://hdl.handle.net/10316/107689; https://doi.org/10.7150/ijms.22891
• topic: Liver transplantation; Mitochondria; Ischemia/reperfusion injury; Liver preservation solution; Pharmacological conditioning; Apoptosis; Humans; Liver; Liver Transplantation; Mitochondria; Protective Agents; Reperfusion Injury

Ischemia/reperfusion (I/R) injury in liver transplantation can disrupt the normal activity of mitochondria in the hepatic parenchyma. This potential dysfunction of mitochondria after I/R injury could be responsible for the initial poor graft function or primary nonfunction observed after liver transplantation. Thus, determining the mechanisms that lead to human hepatic mitochondrial dysfunction might contribute to improving the outcome of liver transplantation. Furthermore, early identification of novel prognostic factors involved in I/R injury could serve as a key endpoint to predict the outcome of liver grafts and also to promote the early adoption of novel strategies that protect against I/R injury. Here, we briefly review recent advances in the study of mitochondrial dysfunction and I/R injury, particularly in relation to liver transplantation. Next, we highlight various pharmacological therapeutic strategies that could be applied, and discuss their relationship to relevant mitochondrion-related processes and targets. Lastly, we note that although considerable progress has been made in our understanding of I/R injury and mitochondrial dysfunction, further investigation is required to elucidate the cellular and molecular mechanisms underlying these processes, thereby identifying biomarkers that can help in evaluating donor organs.