Isolation of secondary metabolites from Geranium molle L. with anticancer potential

Detalhes bibliográficos
Autor(a) principal: Graça, Vânia C.
Data de Publicação: 2018
Outros Autores: Calhelha, Ricardo C., Nunes, Fernando M., Berthet, Jérôme, Ferreira, Isabel C.F.R., Santos, Paulo F.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10198/10469
Resumo: Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.
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spelling Isolation of secondary metabolites from Geranium molle L. with anticancer potentialCytotoxic activityGeranium molle L.Phenolic compoundsSecondary metabolitesTwo flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.This work was supported by European Investment Funds by FEDER/ COMPETE/POCI – Operational Competitiveness and Internationalization Programme, under Project POCI-01-0145-FEDER- 006958 and National Funds by FCT – Portuguese Foundation for Science and Technology under the projects UID/AGR/00690/2013 (CIMO) and UID/QUI/00616/2013 (CQ-VR). V.C. Graça thanks FCT for her grant (SFRH/BD/52542/2014) and L. Barros for her contract. The authors are also grateful to Interreg España-Portugal for financial support through the project 0377_Iberphenol_6_E.Biblioteca Digital do IPBGraça, Vânia C.Calhelha, Ricardo C.Nunes, Fernando M.Berthet, JérômeFerreira, Isabel C.F.R.Santos, Paulo F.2018-01-19T10:00:00Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/10469engGraça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-50926-669010.1016/j.indcrop.2019.111859info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-21T10:45:51Zoai:bibliotecadigital.ipb.pt:10198/10469Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:10:52.175214Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Isolation of secondary metabolites from Geranium molle L. with anticancer potential
title Isolation of secondary metabolites from Geranium molle L. with anticancer potential
spellingShingle Isolation of secondary metabolites from Geranium molle L. with anticancer potential
Graça, Vânia C.
Cytotoxic activity
Geranium molle L.
Phenolic compounds
Secondary metabolites
title_short Isolation of secondary metabolites from Geranium molle L. with anticancer potential
title_full Isolation of secondary metabolites from Geranium molle L. with anticancer potential
title_fullStr Isolation of secondary metabolites from Geranium molle L. with anticancer potential
title_full_unstemmed Isolation of secondary metabolites from Geranium molle L. with anticancer potential
title_sort Isolation of secondary metabolites from Geranium molle L. with anticancer potential
author Graça, Vânia C.
author_facet Graça, Vânia C.
Calhelha, Ricardo C.
Nunes, Fernando M.
Berthet, Jérôme
Ferreira, Isabel C.F.R.
Santos, Paulo F.
author_role author
author2 Calhelha, Ricardo C.
Nunes, Fernando M.
Berthet, Jérôme
Ferreira, Isabel C.F.R.
Santos, Paulo F.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Biblioteca Digital do IPB
dc.contributor.author.fl_str_mv Graça, Vânia C.
Calhelha, Ricardo C.
Nunes, Fernando M.
Berthet, Jérôme
Ferreira, Isabel C.F.R.
Santos, Paulo F.
dc.subject.por.fl_str_mv Cytotoxic activity
Geranium molle L.
Phenolic compounds
Secondary metabolites
topic Cytotoxic activity
Geranium molle L.
Phenolic compounds
Secondary metabolites
description Two flavone glycosides, apigenin-6-C-glucoside (1) and lutelin-6-C-glucoside (2), and an anomeric mixture of 2,3-dygalloyl-4,6-HHDP-D-glucose (3a/3b) were isolated for the first time from Geranium molle L., a medicinal plant used in the folk medicine of northeast of Portugal for the treatment of a variety of ailments, including cancer. The cytotoxic activity of the isolated compounds was assessed against several human tumour cell lines and non-tumour porcine liver primary cells. The anomeric mixture of ellagitannins 3a/3b, with the two anomers showing considerably different hydrophobicities, was found to be significantly cytotoxic against cancer cells, with only moderate hepatotoxicity.
publishDate 2018
dc.date.none.fl_str_mv 2018-01-19T10:00:00Z
2019
2019-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10198/10469
url http://hdl.handle.net/10198/10469
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Graça, V. C.; Calhelha, Ricardo C.; Nunes, Fernando M.; Berthet, Jérôme; Ferreira, Isabel C.F.R.; Santos, P. F. (2019). Isolation of secondary metabolites from Geranium molle L. with anticancer potential. Industrial Crops and Products. ISSN 0926-6690. 142, p. 1-5
0926-6690
10.1016/j.indcrop.2019.111859
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
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repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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