Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models

Detalhes bibliográficos
Autor(a) principal: Bessa, Maria João
Data de Publicação: 2023
Outros Autores: Brandão, Fátima, Rosário, Fernanda, Moreira, Luciana, Reis, Ana Teresa, Valdiglesias, Vanessa, Laffon, Blanca, Fraga, Sónia, Teixeira, João Paulo
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.18/8666
Resumo: Review
id RCAP_625f6a28a2ce42977ead709385c76966
oai_identifier_str oai:repositorio.insa.pt:10400.18/8666
network_acronym_str RCAP
network_name_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository_id_str 7160
spelling Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced modelsNanoparticlesAir-liquid InterfaceIn vitroRespiratory ModelsSubmerged CulturesToxicity TestingToxicologiaReviewSeveral studies have been conducted to address the potential adverse health risks attributed to exposure to nanoscale materials. While in vivo studies are fundamental for identifying the relation-ship between dose and occurrence of adverse effects, in vitro model systems provide important information regarding the mechanism(s) of action at the molecular level. With a special focus on exposure to inhaled (nano)particulate material toxicity assessment, this review provides an over-view of the available human respiratory models and exposure systems for in vitro testing, advan-tages, limitations, and existing investigations using models of different complexity. A brief overview of the human respiratory system, pathway and fate of inhaled (nano)particles is also presented.The work was supported by the Fundação para a Ciência e a Tecnologia [POCI-01-0145-FEDER-029651, SFRH/BPD/122112/2016,PTDC/MED‐TOX/31162/2017, DL-57/INSA06/2018,SFRH/BD/101060/2014,SFRH/BD/120646/2016, SIINN/0004/2014,UIDB/04750/2020, LA/P/0064/2020]; Spanish Ministry of Education, Culture and Sport [BEAGAL18/00142]; Spanish Ministry of Science and Innovation [PID2020-114908GA-I00].Taylor and FrancisRepositório Científico do Instituto Nacional de SaúdeBessa, Maria JoãoBrandão, FátimaRosário, FernandaMoreira, LucianaReis, Ana TeresaValdiglesias, VanessaLaffon, BlancaFraga, SóniaTeixeira, João Paulo2023-10-06T11:23:52Z2023-01-242023-01-24T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/8666engJ Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24. Review1093-740410.1080/10937404.2023.2166638info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-10-14T01:31:33Zoai:repositorio.insa.pt:10400.18/8666Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T20:33:34.116669Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
title Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
spellingShingle Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
Bessa, Maria João
Nanoparticles
Air-liquid Interface
In vitro
Respiratory Models
Submerged Cultures
Toxicity Testing
Toxicologia
title_short Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
title_full Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
title_fullStr Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
title_full_unstemmed Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
title_sort Assessing the in vitro toxicity of airborne (nano)particles to the human respiratory system: from basic to advanced models
author Bessa, Maria João
author_facet Bessa, Maria João
Brandão, Fátima
Rosário, Fernanda
Moreira, Luciana
Reis, Ana Teresa
Valdiglesias, Vanessa
Laffon, Blanca
Fraga, Sónia
Teixeira, João Paulo
author_role author
author2 Brandão, Fátima
Rosário, Fernanda
Moreira, Luciana
Reis, Ana Teresa
Valdiglesias, Vanessa
Laffon, Blanca
Fraga, Sónia
Teixeira, João Paulo
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório Científico do Instituto Nacional de Saúde
dc.contributor.author.fl_str_mv Bessa, Maria João
Brandão, Fátima
Rosário, Fernanda
Moreira, Luciana
Reis, Ana Teresa
Valdiglesias, Vanessa
Laffon, Blanca
Fraga, Sónia
Teixeira, João Paulo
dc.subject.por.fl_str_mv Nanoparticles
Air-liquid Interface
In vitro
Respiratory Models
Submerged Cultures
Toxicity Testing
Toxicologia
topic Nanoparticles
Air-liquid Interface
In vitro
Respiratory Models
Submerged Cultures
Toxicity Testing
Toxicologia
description Review
publishDate 2023
dc.date.none.fl_str_mv 2023-10-06T11:23:52Z
2023-01-24
2023-01-24T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.18/8666
url http://hdl.handle.net/10400.18/8666
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Toxicol Environ Health B Crit Rev. 2023 Feb 17;26(2):67-96. doi: 10.1080/10937404.2023.2166638. Epub 2023 Jan 24. Review
1093-7404
10.1080/10937404.2023.2166638
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor and Francis
publisher.none.fl_str_mv Taylor and Francis
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799133601046986752

Registros relacionados