A structural road map to unveil basal body composition and assembly

Detalhes bibliográficos
Autor(a) principal: Jana, Swadhin C
Data de Publicação: 2012
Outros Autores: Machado, Pedro, Bettencourt-Dias, Mónica
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.7/834
Resumo: The deposited article is a post-print version and has been submitted to peer review.
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spelling A structural road map to unveil basal body composition and assemblyAnimalsCiliaMicrotubulesBasal BodyThe deposited article is a post-print version and has been submitted to peer review.This publication hasn't any creative commons license associated.There is no public supplementary material available.The Basal Body (BB) acts as the template for the axoneme, the microtubule‐basedstructure of cilia and flagella. Although several proteins were recently implicatedin both centriole and BB assembly and function, their molecular mechanisms are stillpoorly characterized. In this issue of The EMBO journal, Li and coworkersdescribe for the first time the near‐native structure of the BB at 33 Åresolution obtained by Cryo‐Electron Microscopy analysis of wild‐type (WT) isolatedChlamydomonas BBs. They identified several uncharacterized non‐tubulinstructures and variations along the length of the BB, which likely reflect thebinding and function of numerous macromolecular complexes. These complexes areexpected to define BB intrinsic properties, such as its characteristic structure andstability. Similarly to the high‐resolution structures of ribosome and nuclear porecomplexes, this study will undoubtedly contribute towards the future analysis ofcentriole and BB biogenesis, maintenance and function.Fundação para a Ciência e Tecnologia grant: (PTDC/BIA‐BCM/105602/2008); EMBO Installation Grant; Instituto Gulbenkian de Ciência; ERC grant(261344—CentriolStructNumber).EMBO PressARCAJana, Swadhin CMachado, PedroBettencourt-Dias, Mónica2018-02-08T17:30:05Z2012-02-012012-02-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.7/834engSwadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.47410.1038/emboj.2011.474info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2022-11-29T14:35:14Zoai:arca.igc.gulbenkian.pt:10400.7/834Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T16:12:03.253641Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv A structural road map to unveil basal body composition and assembly
title A structural road map to unveil basal body composition and assembly
spellingShingle A structural road map to unveil basal body composition and assembly
Jana, Swadhin C
Animals
Cilia
Microtubules
Basal Body
title_short A structural road map to unveil basal body composition and assembly
title_full A structural road map to unveil basal body composition and assembly
title_fullStr A structural road map to unveil basal body composition and assembly
title_full_unstemmed A structural road map to unveil basal body composition and assembly
title_sort A structural road map to unveil basal body composition and assembly
author Jana, Swadhin C
author_facet Jana, Swadhin C
Machado, Pedro
Bettencourt-Dias, Mónica
author_role author
author2 Machado, Pedro
Bettencourt-Dias, Mónica
author2_role author
author
dc.contributor.none.fl_str_mv ARCA
dc.contributor.author.fl_str_mv Jana, Swadhin C
Machado, Pedro
Bettencourt-Dias, Mónica
dc.subject.por.fl_str_mv Animals
Cilia
Microtubules
Basal Body
topic Animals
Cilia
Microtubules
Basal Body
description The deposited article is a post-print version and has been submitted to peer review.
publishDate 2012
dc.date.none.fl_str_mv 2012-02-01
2012-02-01T00:00:00Z
2018-02-08T17:30:05Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.7/834
url http://hdl.handle.net/10400.7/834
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Swadhin C Jana, Pedro Machado, Mónica Bettencourt‐Dias (2012). A structural road map to unveil basal body composition and assembly. EMBO J. 31(3):519-21. DOI 10.1038/emboj.2011.474
10.1038/emboj.2011.474
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv EMBO Press
publisher.none.fl_str_mv EMBO Press
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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