Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats

Detalhes bibliográficos
Autor(a) principal: Faustino-Rocha, Ana Faustino
Data de Publicação: 2020
Outros Autores: Seixas, Fernanda, Ferreira, Rita, Silva, Jessica, Fardilha, Margarida, Oliveira, Paula Alexandra, Ginja, Mário
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10174/31002
https://doi.org/10.21873/invivo.11974
Resumo: Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models.
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spelling Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar ratscarcinogenesisprostaterodentultrasonographyAim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models.In Vivo2022-01-31T16:06:45Z2022-01-312020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/31002http://hdl.handle.net/10174/31002https://doi.org/10.21873/invivo.11974engFaustino-Rocha AI, Seixas F, Ferreira R, Silva J, Fardilha M, Oliveira PA, Ginja M. 2020. Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats. In vivo 34(4): 1797-1803. doi: 10.21873/invivo.11974.1797-1803https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439876/34anafaustino@uevora.ptndndndndndnd206Faustino-Rocha, Ana FaustinoSeixas, FernandaFerreira, RitaSilva, JessicaFardilha, MargaridaOliveira, Paula AlexandraGinja, Márioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:27:37Zoai:dspace.uevora.pt:10174/31002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:19:34.041197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
title Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
spellingShingle Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
Faustino-Rocha, Ana Faustino
carcinogenesis
prostate
rodent
ultrasonography
title_short Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
title_full Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
title_fullStr Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
title_full_unstemmed Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
title_sort Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
author Faustino-Rocha, Ana Faustino
author_facet Faustino-Rocha, Ana Faustino
Seixas, Fernanda
Ferreira, Rita
Silva, Jessica
Fardilha, Margarida
Oliveira, Paula Alexandra
Ginja, Mário
author_role author
author2 Seixas, Fernanda
Ferreira, Rita
Silva, Jessica
Fardilha, Margarida
Oliveira, Paula Alexandra
Ginja, Mário
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Faustino-Rocha, Ana Faustino
Seixas, Fernanda
Ferreira, Rita
Silva, Jessica
Fardilha, Margarida
Oliveira, Paula Alexandra
Ginja, Mário
dc.subject.por.fl_str_mv carcinogenesis
prostate
rodent
ultrasonography
topic carcinogenesis
prostate
rodent
ultrasonography
description Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models.
publishDate 2020
dc.date.none.fl_str_mv 2020-01-01T00:00:00Z
2022-01-31T16:06:45Z
2022-01-31
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10174/31002
http://hdl.handle.net/10174/31002
https://doi.org/10.21873/invivo.11974
url http://hdl.handle.net/10174/31002
https://doi.org/10.21873/invivo.11974
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Faustino-Rocha AI, Seixas F, Ferreira R, Silva J, Fardilha M, Oliveira PA, Ginja M. 2020. Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats. In vivo 34(4): 1797-1803. doi: 10.21873/invivo.11974.
1797-1803
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439876/
34
anafaustino@uevora.pt
nd
nd
nd
nd
nd
nd
206
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv In Vivo
publisher.none.fl_str_mv In Vivo
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
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