Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10174/31002 https://doi.org/10.21873/invivo.11974 |
Resumo: | Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models. |
id |
RCAP_6b7d66779743dd80481534ec72e04c12 |
---|---|
oai_identifier_str |
oai:dspace.uevora.pt:10174/31002 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar ratscarcinogenesisprostaterodentultrasonographyAim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models.In Vivo2022-01-31T16:06:45Z2022-01-312020-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10174/31002http://hdl.handle.net/10174/31002https://doi.org/10.21873/invivo.11974engFaustino-Rocha AI, Seixas F, Ferreira R, Silva J, Fardilha M, Oliveira PA, Ginja M. 2020. Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats. In vivo 34(4): 1797-1803. doi: 10.21873/invivo.11974.1797-1803https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439876/34anafaustino@uevora.ptndndndndndnd206Faustino-Rocha, Ana FaustinoSeixas, FernandaFerreira, RitaSilva, JessicaFardilha, MargaridaOliveira, Paula AlexandraGinja, Márioinfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-01-03T19:27:37Zoai:dspace.uevora.pt:10174/31002Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T01:19:34.041197Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
spellingShingle |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats Faustino-Rocha, Ana Faustino carcinogenesis prostate rodent ultrasonography |
title_short |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_full |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_fullStr |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_full_unstemmed |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_sort |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
author |
Faustino-Rocha, Ana Faustino |
author_facet |
Faustino-Rocha, Ana Faustino Seixas, Fernanda Ferreira, Rita Silva, Jessica Fardilha, Margarida Oliveira, Paula Alexandra Ginja, Mário |
author_role |
author |
author2 |
Seixas, Fernanda Ferreira, Rita Silva, Jessica Fardilha, Margarida Oliveira, Paula Alexandra Ginja, Mário |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Faustino-Rocha, Ana Faustino Seixas, Fernanda Ferreira, Rita Silva, Jessica Fardilha, Margarida Oliveira, Paula Alexandra Ginja, Mário |
dc.subject.por.fl_str_mv |
carcinogenesis prostate rodent ultrasonography |
topic |
carcinogenesis prostate rodent ultrasonography |
description |
Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-01-01T00:00:00Z 2022-01-31T16:06:45Z 2022-01-31 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10174/31002 http://hdl.handle.net/10174/31002 https://doi.org/10.21873/invivo.11974 |
url |
http://hdl.handle.net/10174/31002 https://doi.org/10.21873/invivo.11974 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Faustino-Rocha AI, Seixas F, Ferreira R, Silva J, Fardilha M, Oliveira PA, Ginja M. 2020. Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats. In vivo 34(4): 1797-1803. doi: 10.21873/invivo.11974. 1797-1803 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7439876/ 34 anafaustino@uevora.pt nd nd nd nd nd nd 206 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
In Vivo |
publisher.none.fl_str_mv |
In Vivo |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799136677072994304 |