Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10773/29392 |
Resumo: | Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models. |
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Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar ratsCarcinogenesisProstateRodentUltrasonographyAim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models.International Institute of Anticancer Research2020-10-09T11:35:14Z2020-07-01T00:00:00Z2020-07info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10773/29392eng0258-851X10.21873/invivo.11974Faustino-Rocha, Ana I.Seixas, FernandaFerreira, RitaSilva, JessicaPires, Maria J.Fardilha, MargaridaGinja, MárioOliveira, Paula A.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-02-22T11:56:29Zoai:ria.ua.pt:10773/29392Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:01:35.784533Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
spellingShingle |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats Faustino-Rocha, Ana I. Carcinogenesis Prostate Rodent Ultrasonography |
title_short |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_full |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_fullStr |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_full_unstemmed |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
title_sort |
Ultrasonographic follow-up of the multistep protocol for prostate cancer induction in Wistar rats |
author |
Faustino-Rocha, Ana I. |
author_facet |
Faustino-Rocha, Ana I. Seixas, Fernanda Ferreira, Rita Silva, Jessica Pires, Maria J. Fardilha, Margarida Ginja, Mário Oliveira, Paula A. |
author_role |
author |
author2 |
Seixas, Fernanda Ferreira, Rita Silva, Jessica Pires, Maria J. Fardilha, Margarida Ginja, Mário Oliveira, Paula A. |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Faustino-Rocha, Ana I. Seixas, Fernanda Ferreira, Rita Silva, Jessica Pires, Maria J. Fardilha, Margarida Ginja, Mário Oliveira, Paula A. |
dc.subject.por.fl_str_mv |
Carcinogenesis Prostate Rodent Ultrasonography |
topic |
Carcinogenesis Prostate Rodent Ultrasonography |
description |
Aim: This work intended to improve the knowledge of the rat model of prostate cancer (PCa) by ultrasonographic monitoring. Materials and Methods: Male Wistar rats were divided into control (n=8) and PCa (n=14) groups. PCa development was induced in the PCa group through the sequential administration of the anti-androgenic drug flutamide, testosterone propionate and the carcinogenic N-methyl-N-nitrosourea. The prostate was evaluated by ultrasonography at five timepoints along 49 weeks of the experimental protocol. Ventral prostate lobes were observed in all ultrasonographic examinations. Results: The ventral prostate area of the control group increased gradually between the first and the last ultrasonographic examination. The ventral prostate area of PCa groups decreased due to flutamide administration and increased after androgen and carcinogen administration. The area of the dorsal prostate lobe increased between the fourth and the fifth ultrasonographic examination. In the last ultrasonographic examination, hypoechoic and anechoic lesions were observed in the PCa group. Conclusion: To our knowledge, this is the first study presenting a follow-up of rat prostatic dimensions by ultrasonography. Ultrasonography is a feasible approach for prostate cancer monitoring in experimental models. |
publishDate |
2020 |
dc.date.none.fl_str_mv |
2020-10-09T11:35:14Z 2020-07-01T00:00:00Z 2020-07 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10773/29392 |
url |
http://hdl.handle.net/10773/29392 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
0258-851X 10.21873/invivo.11974 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
International Institute of Anticancer Research |
publisher.none.fl_str_mv |
International Institute of Anticancer Research |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
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1799137671782596608 |