Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization
Autor(a) principal: | |
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Data de Publicação: | 2022 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10198/25894 |
Resumo: | The fig tree (Ficus carica L.) was one of the first domesticated trees. In 2019, the world's fig fruit production was estimated at 1153 tons. However, fig leaves are not utilized, resulting in copious quantities of bio-waste. To identify promising fig tree varieties, hydroethanolic extracts were prepared from the leaves of five fig tree varieties (Pasteliere-PA, Longue d'Aout-LA, Dauphinie-DA, Boujassote Noire-BN, and Marseille-MA). The variety with the highest concentration of organic acids was BN (146.5 mg/g dw), while glucose, fructose, and sucrose were the predominant sugars across all varieties. All extracts present alpha-tocopherol as the prevalent tocopherol isoform (above 78%), while PUFA fatty acids were predominant, ranging from 53% to 71% of total fatty acids. BN showed moderate antioxidant activity (EC50 0.23 +/- 0.01 mg/mL), while the DA variety presented promising cytotoxicity against the tumor AGS and MCF-7 cell line (GI(50) 158 +/- 13 and 223 +/- 21 mu g/mL) and especially in the inhibition of Nitric Oxide Production evaluation (IC50 20 +/- 5 mu g/mL). The DA activities are probably related to high concentrations of flavonoids, specifically the predominant apigenin-C-hexoside-C-pentoside and quercetin-O-deoxyhexosyl-hexoside. Finally, the BN and DA varieties showed good antimicrobial activity, especially against Yersinia enterocolitica. Fig leaves can be considered sustainable sources of industrially valuable bioactive molecules, and several potential applications were highlighted. |
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Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorizationFigsLeavesBioactive compoundsCircular economyThe fig tree (Ficus carica L.) was one of the first domesticated trees. In 2019, the world's fig fruit production was estimated at 1153 tons. However, fig leaves are not utilized, resulting in copious quantities of bio-waste. To identify promising fig tree varieties, hydroethanolic extracts were prepared from the leaves of five fig tree varieties (Pasteliere-PA, Longue d'Aout-LA, Dauphinie-DA, Boujassote Noire-BN, and Marseille-MA). The variety with the highest concentration of organic acids was BN (146.5 mg/g dw), while glucose, fructose, and sucrose were the predominant sugars across all varieties. All extracts present alpha-tocopherol as the prevalent tocopherol isoform (above 78%), while PUFA fatty acids were predominant, ranging from 53% to 71% of total fatty acids. BN showed moderate antioxidant activity (EC50 0.23 +/- 0.01 mg/mL), while the DA variety presented promising cytotoxicity against the tumor AGS and MCF-7 cell line (GI(50) 158 +/- 13 and 223 +/- 21 mu g/mL) and especially in the inhibition of Nitric Oxide Production evaluation (IC50 20 +/- 5 mu g/mL). The DA activities are probably related to high concentrations of flavonoids, specifically the predominant apigenin-C-hexoside-C-pentoside and quercetin-O-deoxyhexosyl-hexoside. Finally, the BN and DA varieties showed good antimicrobial activity, especially against Yersinia enterocolitica. Fig leaves can be considered sustainable sources of industrially valuable bioactive molecules, and several potential applications were highlighted.MDPIBiblioteca Digital do IPBShiraishi, Carlos Seiti HurtadoZbiss, YosraRoriz, Custódio LoboDias, Maria InêsPrieto Lage, Miguel A.Calhelha, Ricardo C.Alves, Maria JoséHeleno, Sandrina A.Mendes, Vasco da CunhaCarocho, MárcioAbreu, Rui M.V.Barros, Lillian2022-09-12T16:05:09Z20232023-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10198/25894engShiraishi, Carlos Seiti Hurtado; Zbiss, Yosra; Roriz, Custódio Lobo; Dias, Maria Inês; Prieto Lage, Miguel A.; Calhelha, Ricardo C.; Alves, Maria José; Heleno, Sandrina A.; Mendes, Vasco da Cunha; Carocho, Márcio; Abreu, Rui M.V.; Barros, Lillian (2023).Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization. Processes. eISSN 2227-9717. 11:4, p. 1-1810.3390/pr110411792227-9717info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-06T01:17:12Zoai:bibliotecadigital.ipb.pt:10198/25894Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T23:16:22.648170Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
title |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
spellingShingle |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization Shiraishi, Carlos Seiti Hurtado Figs Leaves Bioactive compounds Circular economy |
title_short |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
title_full |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
title_fullStr |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
title_full_unstemmed |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
title_sort |
Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization |
author |
Shiraishi, Carlos Seiti Hurtado |
author_facet |
Shiraishi, Carlos Seiti Hurtado Zbiss, Yosra Roriz, Custódio Lobo Dias, Maria Inês Prieto Lage, Miguel A. Calhelha, Ricardo C. Alves, Maria José Heleno, Sandrina A. Mendes, Vasco da Cunha Carocho, Márcio Abreu, Rui M.V. Barros, Lillian |
author_role |
author |
author2 |
Zbiss, Yosra Roriz, Custódio Lobo Dias, Maria Inês Prieto Lage, Miguel A. Calhelha, Ricardo C. Alves, Maria José Heleno, Sandrina A. Mendes, Vasco da Cunha Carocho, Márcio Abreu, Rui M.V. Barros, Lillian |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Biblioteca Digital do IPB |
dc.contributor.author.fl_str_mv |
Shiraishi, Carlos Seiti Hurtado Zbiss, Yosra Roriz, Custódio Lobo Dias, Maria Inês Prieto Lage, Miguel A. Calhelha, Ricardo C. Alves, Maria José Heleno, Sandrina A. Mendes, Vasco da Cunha Carocho, Márcio Abreu, Rui M.V. Barros, Lillian |
dc.subject.por.fl_str_mv |
Figs Leaves Bioactive compounds Circular economy |
topic |
Figs Leaves Bioactive compounds Circular economy |
description |
The fig tree (Ficus carica L.) was one of the first domesticated trees. In 2019, the world's fig fruit production was estimated at 1153 tons. However, fig leaves are not utilized, resulting in copious quantities of bio-waste. To identify promising fig tree varieties, hydroethanolic extracts were prepared from the leaves of five fig tree varieties (Pasteliere-PA, Longue d'Aout-LA, Dauphinie-DA, Boujassote Noire-BN, and Marseille-MA). The variety with the highest concentration of organic acids was BN (146.5 mg/g dw), while glucose, fructose, and sucrose were the predominant sugars across all varieties. All extracts present alpha-tocopherol as the prevalent tocopherol isoform (above 78%), while PUFA fatty acids were predominant, ranging from 53% to 71% of total fatty acids. BN showed moderate antioxidant activity (EC50 0.23 +/- 0.01 mg/mL), while the DA variety presented promising cytotoxicity against the tumor AGS and MCF-7 cell line (GI(50) 158 +/- 13 and 223 +/- 21 mu g/mL) and especially in the inhibition of Nitric Oxide Production evaluation (IC50 20 +/- 5 mu g/mL). The DA activities are probably related to high concentrations of flavonoids, specifically the predominant apigenin-C-hexoside-C-pentoside and quercetin-O-deoxyhexosyl-hexoside. Finally, the BN and DA varieties showed good antimicrobial activity, especially against Yersinia enterocolitica. Fig leaves can be considered sustainable sources of industrially valuable bioactive molecules, and several potential applications were highlighted. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-09-12T16:05:09Z 2023 2023-01-01T00:00:00Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10198/25894 |
url |
http://hdl.handle.net/10198/25894 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Shiraishi, Carlos Seiti Hurtado; Zbiss, Yosra; Roriz, Custódio Lobo; Dias, Maria Inês; Prieto Lage, Miguel A.; Calhelha, Ricardo C.; Alves, Maria José; Heleno, Sandrina A.; Mendes, Vasco da Cunha; Carocho, Márcio; Abreu, Rui M.V.; Barros, Lillian (2023).Fig leaves (Ficus carica L.): source of bioactive ingredients for industrial valorization. Processes. eISSN 2227-9717. 11:4, p. 1-18 10.3390/pr11041179 2227-9717 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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MDPI |
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MDPI |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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