The Adenosinergic System in Diabetic Retinopathy
Autor(a) principal: | |
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Data de Publicação: | 2016 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10316/108643 https://doi.org/10.1155/2016/4270301 |
Resumo: | The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. Herein, we review the studies that explore the impact of diabetic conditions on the retinal adenosinergic system, as well as the role of the said system in ameliorating or exacerbating those conditions. The experimental results described suggest that this system is heavily affected by diabetic conditions and that the modulation of its components could reveal potential therapeutic targets for the treatment of diabetic retinopathy, particularly in the early stages of the disease. |
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The Adenosinergic System in Diabetic RetinopathyAdenosineAnimalsCellular MicroenvironmentDiabetic RetinopathyHumansPurinergic P1 Receptor AntagonistsReceptors, Purinergic P1RetinaSignal TransductionThe neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. Herein, we review the studies that explore the impact of diabetic conditions on the retinal adenosinergic system, as well as the role of the said system in ameliorating or exacerbating those conditions. The experimental results described suggest that this system is heavily affected by diabetic conditions and that the modulation of its components could reveal potential therapeutic targets for the treatment of diabetic retinopathy, particularly in the early stages of the disease.Hindawi2016info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlehttp://hdl.handle.net/10316/108643http://hdl.handle.net/10316/108643https://doi.org/10.1155/2016/4270301eng2314-67452314-6753Vindeirinho, J.Santiago, A. R.Cavadas, CAmbrósio, António F.Santos, P. F.info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-09-06T10:19:58Zoai:estudogeral.uc.pt:10316/108643Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T21:24:55.752851Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
The Adenosinergic System in Diabetic Retinopathy |
title |
The Adenosinergic System in Diabetic Retinopathy |
spellingShingle |
The Adenosinergic System in Diabetic Retinopathy Vindeirinho, J. Adenosine Animals Cellular Microenvironment Diabetic Retinopathy Humans Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 Retina Signal Transduction |
title_short |
The Adenosinergic System in Diabetic Retinopathy |
title_full |
The Adenosinergic System in Diabetic Retinopathy |
title_fullStr |
The Adenosinergic System in Diabetic Retinopathy |
title_full_unstemmed |
The Adenosinergic System in Diabetic Retinopathy |
title_sort |
The Adenosinergic System in Diabetic Retinopathy |
author |
Vindeirinho, J. |
author_facet |
Vindeirinho, J. Santiago, A. R. Cavadas, C Ambrósio, António F. Santos, P. F. |
author_role |
author |
author2 |
Santiago, A. R. Cavadas, C Ambrósio, António F. Santos, P. F. |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Vindeirinho, J. Santiago, A. R. Cavadas, C Ambrósio, António F. Santos, P. F. |
dc.subject.por.fl_str_mv |
Adenosine Animals Cellular Microenvironment Diabetic Retinopathy Humans Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 Retina Signal Transduction |
topic |
Adenosine Animals Cellular Microenvironment Diabetic Retinopathy Humans Purinergic P1 Receptor Antagonists Receptors, Purinergic P1 Retina Signal Transduction |
description |
The neurodegenerative and inflammatory environment that is prevalent in the diabetic eye is a key player in the development and progression of diabetic retinopathy. The adenosinergic system is widely regarded as a significant modulator of neurotransmission and the inflammatory response, through the actions of the four types of adenosine receptors (A1R, A2AR, A2BR, and A3R), and thus could be revealed as a potential player in the events unfolding in the early stages of diabetic retinopathy. Herein, we review the studies that explore the impact of diabetic conditions on the retinal adenosinergic system, as well as the role of the said system in ameliorating or exacerbating those conditions. The experimental results described suggest that this system is heavily affected by diabetic conditions and that the modulation of its components could reveal potential therapeutic targets for the treatment of diabetic retinopathy, particularly in the early stages of the disease. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10316/108643 http://hdl.handle.net/10316/108643 https://doi.org/10.1155/2016/4270301 |
url |
http://hdl.handle.net/10316/108643 https://doi.org/10.1155/2016/4270301 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
2314-6745 2314-6753 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Hindawi |
publisher.none.fl_str_mv |
Hindawi |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799134132752613376 |