A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3651 |
Resumo: | Background: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm. Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Results: Among 643 patients, actual 5-year overall survival (OS) after resection for ICC was 42.7%. On multivariable analysis, CA19-9 > 200 (hazard ratio (HR), 2.62; 95% CI, 2.01-3.42), sum of the number and largest tumor size >7 (HR, 1.88; 95% CI, 1.46-2.42), N1 disease (HR, 2.87; 95% CI, 1.98-4.16), R1 resection (HR, 1.72; 95% CI, 1.21-2.46), poor/undifferentiated tumor grade (HR, 1.74; 95% CI, 1.25-2.44), major vascular invasion (HR, 1.47; 95% CI, 1.03-2.10), and adjuvant chemotherapy (HR, 0.64; 95% CI, 0.45-0.89) were significantly associated with survival and were included in the online calculator. The predictive accuracy of the model was good to very good as the C-statistics to predict 5-year OS was 0.696 in the training dataset and 0.672 with bootstrapping resamples (n = 5000) in the test dataset. Conclusion: A novel, online calculator was developed to estimate the 5-year survival probability for patients undergoing resection for ICC. This tool could help provide useful information to guide treatment decision-making and inform conversations about prognosis. |
id |
RCAP_74923fea6f332e8f546fab938cd0289c |
---|---|
oai_identifier_str |
oai:repositorio.chlc.min-saude.pt:10400.17/3651 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" ParadigmAgedBile Duct NeoplasmsCholangiocarcinomaFemaleHumansMaleMiddle AgedOnline SystemsPredictive Value of TestsPrognosisSurvival RateBile Ducts, IntrahepaticHepatectomyHCC CIRBackground: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm. Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Results: Among 643 patients, actual 5-year overall survival (OS) after resection for ICC was 42.7%. On multivariable analysis, CA19-9 > 200 (hazard ratio (HR), 2.62; 95% CI, 2.01-3.42), sum of the number and largest tumor size >7 (HR, 1.88; 95% CI, 1.46-2.42), N1 disease (HR, 2.87; 95% CI, 1.98-4.16), R1 resection (HR, 1.72; 95% CI, 1.21-2.46), poor/undifferentiated tumor grade (HR, 1.74; 95% CI, 1.25-2.44), major vascular invasion (HR, 1.47; 95% CI, 1.03-2.10), and adjuvant chemotherapy (HR, 0.64; 95% CI, 0.45-0.89) were significantly associated with survival and were included in the online calculator. The predictive accuracy of the model was good to very good as the C-statistics to predict 5-year OS was 0.696 in the training dataset and 0.672 with bootstrapping resamples (n = 5000) in the test dataset. Conclusion: A novel, online calculator was developed to estimate the 5-year survival probability for patients undergoing resection for ICC. This tool could help provide useful information to guide treatment decision-making and inform conversations about prognosis.WileyRepositório do Centro Hospitalar Universitário de Lisboa Central, EPESahara, KTsilimigras, DMehta, RBagante, FGuglielmi, AAldrighetti, LAlexandrescu, SPinto Marques, HShen, FKoerkamp, BEndo, IPawlik, T2021-04-14T14:01:10Z2019-082019-08-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3651engJ Surg Oncol. 2019 Aug;120(2):223-230.10.1002/jso.25480info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:43:53Zoai:repositorio.chlc.min-saude.pt:10400.17/3651Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:57.126011Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
title |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
spellingShingle |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm Sahara, K Aged Bile Duct Neoplasms Cholangiocarcinoma Female Humans Male Middle Aged Online Systems Predictive Value of Tests Prognosis Survival Rate Bile Ducts, Intrahepatic Hepatectomy HCC CIR |
title_short |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
title_full |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
title_fullStr |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
title_full_unstemmed |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
title_sort |
A Novel Online Prognostic Tool to Predict Long-Term Survival after Liver Resection for Intrahepatic Cholangiocarcinoma: The "Metro-Ticket" Paradigm |
author |
Sahara, K |
author_facet |
Sahara, K Tsilimigras, D Mehta, R Bagante, F Guglielmi, A Aldrighetti, L Alexandrescu, S Pinto Marques, H Shen, F Koerkamp, B Endo, I Pawlik, T |
author_role |
author |
author2 |
Tsilimigras, D Mehta, R Bagante, F Guglielmi, A Aldrighetti, L Alexandrescu, S Pinto Marques, H Shen, F Koerkamp, B Endo, I Pawlik, T |
author2_role |
author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Sahara, K Tsilimigras, D Mehta, R Bagante, F Guglielmi, A Aldrighetti, L Alexandrescu, S Pinto Marques, H Shen, F Koerkamp, B Endo, I Pawlik, T |
dc.subject.por.fl_str_mv |
Aged Bile Duct Neoplasms Cholangiocarcinoma Female Humans Male Middle Aged Online Systems Predictive Value of Tests Prognosis Survival Rate Bile Ducts, Intrahepatic Hepatectomy HCC CIR |
topic |
Aged Bile Duct Neoplasms Cholangiocarcinoma Female Humans Male Middle Aged Online Systems Predictive Value of Tests Prognosis Survival Rate Bile Ducts, Intrahepatic Hepatectomy HCC CIR |
description |
Background: The aim of the current study was to develop an online calculator to predict survival after liver resection for intrahepatic cholangiocarcinoma (ICC) based on the "metro-ticket" paradigm. Methods: Between 1990 and 2016, patients who underwent liver resection for ICC were identified in an international multi-institutional database. The final multivariable model of survival was used to develop an online prognostic calculator of survival. Results: Among 643 patients, actual 5-year overall survival (OS) after resection for ICC was 42.7%. On multivariable analysis, CA19-9 > 200 (hazard ratio (HR), 2.62; 95% CI, 2.01-3.42), sum of the number and largest tumor size >7 (HR, 1.88; 95% CI, 1.46-2.42), N1 disease (HR, 2.87; 95% CI, 1.98-4.16), R1 resection (HR, 1.72; 95% CI, 1.21-2.46), poor/undifferentiated tumor grade (HR, 1.74; 95% CI, 1.25-2.44), major vascular invasion (HR, 1.47; 95% CI, 1.03-2.10), and adjuvant chemotherapy (HR, 0.64; 95% CI, 0.45-0.89) were significantly associated with survival and were included in the online calculator. The predictive accuracy of the model was good to very good as the C-statistics to predict 5-year OS was 0.696 in the training dataset and 0.672 with bootstrapping resamples (n = 5000) in the test dataset. Conclusion: A novel, online calculator was developed to estimate the 5-year survival probability for patients undergoing resection for ICC. This tool could help provide useful information to guide treatment decision-making and inform conversations about prognosis. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-08 2019-08-01T00:00:00Z 2021-04-14T14:01:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3651 |
url |
http://hdl.handle.net/10400.17/3651 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Surg Oncol. 2019 Aug;120(2):223-230. 10.1002/jso.25480 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131305748725760 |