Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
Autor(a) principal: | |
---|---|
Data de Publicação: | 2019 |
Outros Autores: | , , , , , , , , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Texto Completo: | http://hdl.handle.net/10400.17/3643 |
Resumo: | Background: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%. |
id |
RCAP_b65c7387f40969b2dc9274724ab3a5d3 |
---|---|
oai_identifier_str |
oai:repositorio.chlc.min-saude.pt:10400.17/3643 |
network_acronym_str |
RCAP |
network_name_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository_id_str |
7160 |
spelling |
Survival after Resection of Multiple Tumor Foci of Intrahepatic CholangiocarcinomaAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaEuropeFemaleHepatectomyHumansMaleMiddle AgedSurvival RateUnited StatesHCC CIRBackground: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%.SpringerRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBuettner, STen Cate, DBagante, FAlexandrescu, SPinto Marques, HLamelas, JAldrighetti, LGamblin, TMaithel, SPulitano, CMargonis, GWeiss, MBauer, TShen, FPoultsides, GMarsh, JIJzermans, JPawlik, TKoerkamp, B2021-04-14T10:39:10Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3643engJ Gastrointest Surg. 2019 Nov;23(11):2239-2246.10.1007/s11605-019-04184-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:43:52Zoai:repositorio.chlc.min-saude.pt:10400.17/3643Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:56.626540Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
title |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
spellingShingle |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma Buettner, S Aged Bile Duct Neoplasms Bile Ducts, Intrahepatic Cholangiocarcinoma Europe Female Hepatectomy Humans Male Middle Aged Survival Rate United States HCC CIR |
title_short |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
title_full |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
title_fullStr |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
title_full_unstemmed |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
title_sort |
Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma |
author |
Buettner, S |
author_facet |
Buettner, S Ten Cate, D Bagante, F Alexandrescu, S Pinto Marques, H Lamelas, J Aldrighetti, L Gamblin, T Maithel, S Pulitano, C Margonis, G Weiss, M Bauer, T Shen, F Poultsides, G Marsh, J IJzermans, J Pawlik, T Koerkamp, B |
author_role |
author |
author2 |
Ten Cate, D Bagante, F Alexandrescu, S Pinto Marques, H Lamelas, J Aldrighetti, L Gamblin, T Maithel, S Pulitano, C Margonis, G Weiss, M Bauer, T Shen, F Poultsides, G Marsh, J IJzermans, J Pawlik, T Koerkamp, B |
author2_role |
author author author author author author author author author author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE |
dc.contributor.author.fl_str_mv |
Buettner, S Ten Cate, D Bagante, F Alexandrescu, S Pinto Marques, H Lamelas, J Aldrighetti, L Gamblin, T Maithel, S Pulitano, C Margonis, G Weiss, M Bauer, T Shen, F Poultsides, G Marsh, J IJzermans, J Pawlik, T Koerkamp, B |
dc.subject.por.fl_str_mv |
Aged Bile Duct Neoplasms Bile Ducts, Intrahepatic Cholangiocarcinoma Europe Female Hepatectomy Humans Male Middle Aged Survival Rate United States HCC CIR |
topic |
Aged Bile Duct Neoplasms Bile Ducts, Intrahepatic Cholangiocarcinoma Europe Female Hepatectomy Humans Male Middle Aged Survival Rate United States HCC CIR |
description |
Background: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-04-14T10:39:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.17/3643 |
url |
http://hdl.handle.net/10400.17/3643 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
J Gastrointest Surg. 2019 Nov;23(11):2239-2246. 10.1007/s11605-019-04184-2 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Springer |
publisher.none.fl_str_mv |
Springer |
dc.source.none.fl_str_mv |
reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
instname_str |
Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
instacron_str |
RCAAP |
institution |
RCAAP |
reponame_str |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
collection |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
repository.name.fl_str_mv |
Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
repository.mail.fl_str_mv |
|
_version_ |
1799131305734045696 |