Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma

Detalhes bibliográficos
Autor(a) principal: Buettner, S
Data de Publicação: 2019
Outros Autores: Ten Cate, D, Bagante, F, Alexandrescu, S, Pinto Marques, H, Lamelas, J, Aldrighetti, L, Gamblin, T, Maithel, S, Pulitano, C, Margonis, G, Weiss, M, Bauer, T, Shen, F, Poultsides, G, Marsh, J, IJzermans, J, Pawlik, T, Koerkamp, B
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Texto Completo: http://hdl.handle.net/10400.17/3643
Resumo: Background: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%.
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spelling Survival after Resection of Multiple Tumor Foci of Intrahepatic CholangiocarcinomaAgedBile Duct NeoplasmsBile Ducts, IntrahepaticCholangiocarcinomaEuropeFemaleHepatectomyHumansMaleMiddle AgedSurvival RateUnited StatesHCC CIRBackground: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%.SpringerRepositório do Centro Hospitalar Universitário de Lisboa Central, EPEBuettner, STen Cate, DBagante, FAlexandrescu, SPinto Marques, HLamelas, JAldrighetti, LGamblin, TMaithel, SPulitano, CMargonis, GWeiss, MBauer, TShen, FPoultsides, GMarsh, JIJzermans, JPawlik, TKoerkamp, B2021-04-14T10:39:10Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.17/3643engJ Gastrointest Surg. 2019 Nov;23(11):2239-2246.10.1007/s11605-019-04184-2info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-03-10T09:43:52Zoai:repositorio.chlc.min-saude.pt:10400.17/3643Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T17:20:56.626540Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
title Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
spellingShingle Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
Buettner, S
Aged
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Cholangiocarcinoma
Europe
Female
Hepatectomy
Humans
Male
Middle Aged
Survival Rate
United States
HCC CIR
title_short Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
title_full Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
title_fullStr Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
title_full_unstemmed Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
title_sort Survival after Resection of Multiple Tumor Foci of Intrahepatic Cholangiocarcinoma
author Buettner, S
author_facet Buettner, S
Ten Cate, D
Bagante, F
Alexandrescu, S
Pinto Marques, H
Lamelas, J
Aldrighetti, L
Gamblin, T
Maithel, S
Pulitano, C
Margonis, G
Weiss, M
Bauer, T
Shen, F
Poultsides, G
Marsh, J
IJzermans, J
Pawlik, T
Koerkamp, B
author_role author
author2 Ten Cate, D
Bagante, F
Alexandrescu, S
Pinto Marques, H
Lamelas, J
Aldrighetti, L
Gamblin, T
Maithel, S
Pulitano, C
Margonis, G
Weiss, M
Bauer, T
Shen, F
Poultsides, G
Marsh, J
IJzermans, J
Pawlik, T
Koerkamp, B
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Repositório do Centro Hospitalar Universitário de Lisboa Central, EPE
dc.contributor.author.fl_str_mv Buettner, S
Ten Cate, D
Bagante, F
Alexandrescu, S
Pinto Marques, H
Lamelas, J
Aldrighetti, L
Gamblin, T
Maithel, S
Pulitano, C
Margonis, G
Weiss, M
Bauer, T
Shen, F
Poultsides, G
Marsh, J
IJzermans, J
Pawlik, T
Koerkamp, B
dc.subject.por.fl_str_mv Aged
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Cholangiocarcinoma
Europe
Female
Hepatectomy
Humans
Male
Middle Aged
Survival Rate
United States
HCC CIR
topic Aged
Bile Duct Neoplasms
Bile Ducts, Intrahepatic
Cholangiocarcinoma
Europe
Female
Hepatectomy
Humans
Male
Middle Aged
Survival Rate
United States
HCC CIR
description Background: Multiple tumor foci of intrahepatic cholangiocarcinoma (ICC) are often considered a contra-indication for resection. We sought to define long-term outcomes after resection of ICC in patients with multiple foci. Methods: Patients who underwent resection for ICC between 1990 and 2017 were identified from 12 major HPB centers. Outcomes of patients with solitary lesions, multiple lesions (ML), and oligometastases (OM) were compared. OM were defined as extrahepatic metastases spread to a single organ. Results: One thousand thirteen patients underwent resection of ICC. On final pathology, 185 patients (18.4%) had ML and 27 (2.7%) had OM. Median survival of patients with a solitary tumor was 43.2 months, while the median survival of patients with 2 tumors was 21.2 months; the median survival of patients with 3 or more tumors was 15.3 months (p < 0.001). Five-year survival was 43.3%, 28.0%, and 8.6%, respectively. The median survival of patients without OM was 37.8 months versus 14.9 months among patients with OM (p < 0.001); estimated 5-year survival was 39.3% and 10.6%, respectively. In multivariable analysis, the presence of two lesions was not an independent poor prognostic factor for OS (HR 1.19; 95%CI 0.90-1.57; p = 0.229). However, the presence of three or more tumors was an independent poor prognostic factor for OS (HR 1.97; 95%CI 1.48-2.64; p < 0.001). Conclusion: Resection of multiple liver tumors for patients with ICC did not preclude 5-year survival: in particular, estimated 5-year OS for resection of two tumors was 28.0%.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01T00:00:00Z
2021-04-14T10:39:10Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10400.17/3643
url http://hdl.handle.net/10400.17/3643
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv J Gastrointest Surg. 2019 Nov;23(11):2239-2246.
10.1007/s11605-019-04184-2
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
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