Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach
Main Author: | |
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Publication Date: | 2019 |
Other Authors: | , , , , , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.18/6503 |
Summary: | Mycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015–2016). Following a salt assisted matrix extraction, urine samples were analysed by liquid chromatography–mass spectrometry for the simultaneous determination of 37 urinary mycotoxins’ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure. |
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Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approachBiomarkers of ExposureHuman BiomonitoringMycotoxinsPortugalRisk AssessmentSegurança AlimentarToxicologiaAvaliação de RiscoSaúde HumanaMycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015–2016). Following a salt assisted matrix extraction, urine samples were analysed by liquid chromatography–mass spectrometry for the simultaneous determination of 37 urinary mycotoxins’ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure.Thanks are due to FCT/MCTES for the financial support to CESAM (UID/AMB/50017/2019), through national funds. This research was also supported by the project MYTOX-SOUTH, Ghent University Global Minds programme. IAN-AF national survey was funded by the EEA Grants Program, Public Health Initiatives (PT06 - 000088SI3).Elsevier/ Urban and FischerRepositório Científico do Instituto Nacional de SaúdeMartins, CarlaVidal, A.De Boevre, M.De Saeger, S.Nunes, C.Torres, D.Goios, A.Lopes, C.Assunção, RAlvito, P.2020-04-24T06:52:58Z2019-06-262019-06-26T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.18/6503engInt J Hyg Environ Health. 2019 Jul;222(6):913-925. doi: 10.1016/j.ijheh.2019.06.010. Epub 2019 Jun 261438-4639doi: 10.1016/j.ijheh.2019.06.010info:eu-repo/semantics/embargoedAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-20T15:41:26Zoai:repositorio.insa.pt:10400.18/6503Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:41:07.673860Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
title |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
spellingShingle |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach Martins, Carla Biomarkers of Exposure Human Biomonitoring Mycotoxins Portugal Risk Assessment Segurança Alimentar Toxicologia Avaliação de Risco Saúde Humana |
title_short |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
title_full |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
title_fullStr |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
title_full_unstemmed |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
title_sort |
Exposure assessment of Portuguese population to multiple mycotoxins: the human biomonitoring approach |
author |
Martins, Carla |
author_facet |
Martins, Carla Vidal, A. De Boevre, M. De Saeger, S. Nunes, C. Torres, D. Goios, A. Lopes, C. Assunção, R Alvito, P. |
author_role |
author |
author2 |
Vidal, A. De Boevre, M. De Saeger, S. Nunes, C. Torres, D. Goios, A. Lopes, C. Assunção, R Alvito, P. |
author2_role |
author author author author author author author author author |
dc.contributor.none.fl_str_mv |
Repositório Científico do Instituto Nacional de Saúde |
dc.contributor.author.fl_str_mv |
Martins, Carla Vidal, A. De Boevre, M. De Saeger, S. Nunes, C. Torres, D. Goios, A. Lopes, C. Assunção, R Alvito, P. |
dc.subject.por.fl_str_mv |
Biomarkers of Exposure Human Biomonitoring Mycotoxins Portugal Risk Assessment Segurança Alimentar Toxicologia Avaliação de Risco Saúde Humana |
topic |
Biomarkers of Exposure Human Biomonitoring Mycotoxins Portugal Risk Assessment Segurança Alimentar Toxicologia Avaliação de Risco Saúde Humana |
description |
Mycotoxins constitute a relevant group of food contaminants with several associated health outcomes such as estrogenic, immunotoxic, nephrotoxic and teratogenic effects. Although scarce data are available in Portugal, human biomonitoring studies have been globally developed to assess the exposure to mycotoxins at individual level. In order to overcome this lack of data, the present study concerned the analysis of mycotoxins in 24h urine and first-morning urine paired samples from 94 participants enrolled within the scope of the National Food, Nutrition, and Physical Activity Survey of the Portuguese General Population (2015–2016). Following a salt assisted matrix extraction, urine samples were analysed by liquid chromatography–mass spectrometry for the simultaneous determination of 37 urinary mycotoxins’ biomarkers and data obtained used to estimate the probable daily intake as well as the risk characterization applying the Hazard Quotient approach. Results revealed the exposure of Portuguese population to zearalenone, deoxynivalenol, ochratoxin A, alternariol, citrinin and fumonisin B1 through the quantification in 24h urine and first-morning urine paired samples. Risk characterization data revealed a potential concern to some reported mycotoxins since the reference intake values were exceeded by some of the considered participants. Alternariol was identified for the first time in urine samples from a European country; however, risk characterization was not performed due to lack of reference intake value. These results confirmed mycotoxins as part of the human exposome of the Portuguese population reinforcing the need for further studies regarding the determinants of exposure. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019-06-26 2019-06-26T00:00:00Z 2020-04-24T06:52:58Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.18/6503 |
url |
http://hdl.handle.net/10400.18/6503 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Int J Hyg Environ Health. 2019 Jul;222(6):913-925. doi: 10.1016/j.ijheh.2019.06.010. Epub 2019 Jun 26 1438-4639 doi: 10.1016/j.ijheh.2019.06.010 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/embargoedAccess |
eu_rights_str_mv |
embargoedAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier/ Urban and Fischer |
publisher.none.fl_str_mv |
Elsevier/ Urban and Fischer |
dc.source.none.fl_str_mv |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799132154307805184 |