Vitamin D and Age-Related Macular Degeneration

• Autor(a) principal: Layana, Alfredo Garcia
• Data de Publicação: 2017
• Outros Autores: Minnella, Angelo Maria, Garhöfer, Gerhard, Aslam, Tariq, Holz, Frank G, Leys, Anita, Silva, Rufino, Delcourt, Cécile, Souied, Eric, Seddon, Johanna M.
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
• Texto Completo: http://hdl.handle.net/10316/108289; https://doi.org/10.3390/nu9101120
• topic: vitamin D; age-related macular degeneration; inflammation; angiogenesis; Animals; Biomarkers; Humans; Macular Degeneration; Prognosis; Risk Assessment; Risk Factors; Vitamin D; Vitamin D Deficiency

In recent years, the relationship between vitamin D and health has received growing attention from the scientific and medical communities. Vitamin D deficiencies have been repeatedly associated with various acute and chronic diseases, including age-related macular degeneration (AMD). Its active metabolite, 1α,25-dihydoxy vitamin D, acts as a modulator of cell proliferation, differentiation and apoptosis, and cumulative data from experimental and observational studies suggest that relatively a lower vitamin D status could be a potential risk factor for the development of early and/or late AMD. Herein, we made a narrative review of the mechanisms linking a potential role of vitamin D with the current concepts of AMD pathophysiology.