Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration
Main Author: | |
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Publication Date: | 2019 |
Other Authors: | , , , , |
Format: | Article |
Language: | eng |
Source: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
Download full: | http://hdl.handle.net/10400.6/7213 |
Summary: | Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranes-based drug delivery systems to be used as wound dressings. |
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Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regenerationDrug delivery systemsElectrospun membranesIbuprofenLavender oilWound dressingNanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranes-based drug delivery systems to be used as wound dressings.ElsevieruBibliorumSequeira, Rosa Maria SaraivaMiguel, SóniaCabral, Cátia S. D.Moreira, AndréFerreira, PaulaCorreia, I.J.2021-08-30T00:30:10Z20192019-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10400.6/7213eng10.1016/j.ijpharm.2019.118640info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-12-15T09:46:23Zoai:ubibliorum.ubi.pt:10400.6/7213Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T00:47:46.467461Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
dc.title.none.fl_str_mv |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
title |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
spellingShingle |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration Sequeira, Rosa Maria Saraiva Drug delivery systems Electrospun membranes Ibuprofen Lavender oil Wound dressing |
title_short |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
title_full |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
title_fullStr |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
title_full_unstemmed |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
title_sort |
Development of a poly(vinyl alcohol)/lysine electrospun membrane-based drug delivery system for improved skin regeneration |
author |
Sequeira, Rosa Maria Saraiva |
author_facet |
Sequeira, Rosa Maria Saraiva Miguel, Sónia Cabral, Cátia S. D. Moreira, André Ferreira, Paula Correia, I.J. |
author_role |
author |
author2 |
Miguel, Sónia Cabral, Cátia S. D. Moreira, André Ferreira, Paula Correia, I.J. |
author2_role |
author author author author author |
dc.contributor.none.fl_str_mv |
uBibliorum |
dc.contributor.author.fl_str_mv |
Sequeira, Rosa Maria Saraiva Miguel, Sónia Cabral, Cátia S. D. Moreira, André Ferreira, Paula Correia, I.J. |
dc.subject.por.fl_str_mv |
Drug delivery systems Electrospun membranes Ibuprofen Lavender oil Wound dressing |
topic |
Drug delivery systems Electrospun membranes Ibuprofen Lavender oil Wound dressing |
description |
Nanofiber-based wound dressings are currently being explored as delivery systems of different biomolecules for avoiding skin infections as well as improve/accelerate the healing process. In the present work, a nanofibrous membrane composed of poly(vinyl alcohol) (PVA) and lysine (Lys) was produced by using the electrospinning technique. Further, anti-inflammatory (ibuprofen (IBP)) and antibacterial (lavender oil (LO)) agents were incorporated within the electrospun membrane through blend electrospinning and surface physical adsorption methods, respectively. The obtained results demonstrated that the PVA_Lys electrospun membranes incorporating IBP or LO displayed the suitable morphological, mechanical and biological properties for enhancing the wound healing process. Moreover, the controlled and sustained release profile attained for IBP was appropriate for the duration of the wound healing inflammatory phase, whereas the initial burst release of LO is crucial to prevent wound bacterial contamination. Indeed, the PVA_Lys_LO electrospun membranes were able to mediate a strong antibacterial activity against both S. aureus and P. aeruginosa, without compromising human fibroblasts viability. Overall, the gathered data emphasizes the potential of the PVA_Lys electrospun membranes-based drug delivery systems to be used as wound dressings. |
publishDate |
2019 |
dc.date.none.fl_str_mv |
2019 2019-01-01T00:00:00Z 2021-08-30T00:30:10Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10400.6/7213 |
url |
http://hdl.handle.net/10400.6/7213 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
10.1016/j.ijpharm.2019.118640 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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1799136372790919168 |