Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview
| Autor(a) principal: | |
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| Data de Publicação: | 2021 |
| Outros Autores: | , , , , , , , , , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/1822/73407 |
Resumo: | Journal pre-proofs |
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Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overviewCurcumin (CUR)Drug delivery systems (DDS)Bioactive encapsulationNanotechnologyCancer therapyNanostructuresCiências Médicas::Biotecnologia MédicaScience & TechnologyJournal pre-proofsCurcumin (CUR) is a phenolic compound present in some herbs, including Curcuma longa Linn. (turmeric rhizome), with a high bioactive capacity and characteristic yellow color. It is mainly used as a spice, although it has been found that CUR has interesting pharmaceutical properties, acting as a natural antioxidant, anti-inflammatory, antimicrobial, and antitumoral agent. Nonetheless, CUR is a hydrophobic compound with low water solubility, poor chemical stability, and fast metabolism, limiting its use as a pharmacological compound. Smart drug delivery systems (DDS) have been used to overcome its low bioavailability and improve its stability. The current work overviews the literature from the past 10 years on the encapsulation of CUR in nanostructured systems, such as micelles, liposomes, niosomes, nanoemulsions, hydrogels, and nanocomplexes, emphasizing its use and ability in cancer therapy. The studies highlighted in this review have shown that these nanoformulations achieved higher solubility, improved tumor cytotoxicity, prolonged CUR release, and reduced side effects, among other interesting advantages.This study was funded by the Coordination for Higher Level Graduate Improvements (CAPES/Brazil, finance code 001), National Council for Scientific and Technological Development (CNPq/Brazil, PIBIC process #123483/2020-4), State of São Paulo Research Foundation (FAPESP/Brazil, processes #2017/10789-1, #2018/10799-0, #2018/06475-4, #2018/07707-6, #2019/08549-8, and #2020/03727-2). This work was also supported by the Portuguese Foundation for Science and Technology (FCT) under the scope of the strategic funding of UIDB/04469/2020 unit and the project AgriFood XXI (NORTE-01-0145-FEDER-000041) funded by the European Regional Development Fund under the scope of Norte2020 - Programa Operacional Regional do Norte. Our Figures were created with BioRenderinfo:eu-repo/semantics/publishedVersionElsevierUniversidade do MinhoD'Angelo, Natália A.Noronha, Mariana A.Kurnik, Isabelle S.Câmara, Mayra C. C.Vieira, JorgeAbrunhosa, LuísMartins, Joana T.Alves, Thais F. R.Tundisi, Louise L.Ataide, Janaina A.Costa, Juliana S. R.Jozala, Angela F.Nascimento, Laura O.Mazzola, Priscila G.Chaud, Marco V.Vicente, A. A.Lopes, André M.2021-07-152021-07-15T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/1822/73407engD'Angelo, Natália A.; Noronha, Mariana A.; Kurnik, Isabelle S.; Câmara, Mayra C. C.; Vieira, J.; Abrunhosa, Luís; Martins, Joana T.; Alves, Thais F. R.; Tundisi, Louise L.; Ataide, Janaina A.; Costa, Juliana S. R.; Jozala, Angela F.; Nascimento, Laura O.; Mazzola, Priscila G.; Chaud, Marco V.; Vicente, António A.; Lopes, André M., Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview. International Journal of Pharmaceutics, 604(120534), 20210378517310.1016/j.ijpharm.2021.12053433781887https://www.sciencedirect.com/science/article/pii/S0378517321003392info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-07-21T12:06:56Zoai:repositorium.sdum.uminho.pt:1822/73407Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T18:57:45.979070Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| title |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| spellingShingle |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview D'Angelo, Natália A. Curcumin (CUR) Drug delivery systems (DDS) Bioactive encapsulation Nanotechnology Cancer therapy Nanostructures Ciências Médicas::Biotecnologia Médica Science & Technology |
| title_short |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| title_full |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| title_fullStr |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| title_full_unstemmed |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| title_sort |
Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview |
| author |
D'Angelo, Natália A. |
| author_facet |
D'Angelo, Natália A. Noronha, Mariana A. Kurnik, Isabelle S. Câmara, Mayra C. C. Vieira, Jorge Abrunhosa, Luís Martins, Joana T. Alves, Thais F. R. Tundisi, Louise L. Ataide, Janaina A. Costa, Juliana S. R. Jozala, Angela F. Nascimento, Laura O. Mazzola, Priscila G. Chaud, Marco V. Vicente, A. A. Lopes, André M. |
| author_role |
author |
| author2 |
Noronha, Mariana A. Kurnik, Isabelle S. Câmara, Mayra C. C. Vieira, Jorge Abrunhosa, Luís Martins, Joana T. Alves, Thais F. R. Tundisi, Louise L. Ataide, Janaina A. Costa, Juliana S. R. Jozala, Angela F. Nascimento, Laura O. Mazzola, Priscila G. Chaud, Marco V. Vicente, A. A. Lopes, André M. |
| author2_role |
author author author author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade do Minho |
| dc.contributor.author.fl_str_mv |
D'Angelo, Natália A. Noronha, Mariana A. Kurnik, Isabelle S. Câmara, Mayra C. C. Vieira, Jorge Abrunhosa, Luís Martins, Joana T. Alves, Thais F. R. Tundisi, Louise L. Ataide, Janaina A. Costa, Juliana S. R. Jozala, Angela F. Nascimento, Laura O. Mazzola, Priscila G. Chaud, Marco V. Vicente, A. A. Lopes, André M. |
| dc.subject.por.fl_str_mv |
Curcumin (CUR) Drug delivery systems (DDS) Bioactive encapsulation Nanotechnology Cancer therapy Nanostructures Ciências Médicas::Biotecnologia Médica Science & Technology |
| topic |
Curcumin (CUR) Drug delivery systems (DDS) Bioactive encapsulation Nanotechnology Cancer therapy Nanostructures Ciências Médicas::Biotecnologia Médica Science & Technology |
| description |
Journal pre-proofs |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2021-07-15 2021-07-15T00:00:00Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/1822/73407 |
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http://hdl.handle.net/1822/73407 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
D'Angelo, Natália A.; Noronha, Mariana A.; Kurnik, Isabelle S.; Câmara, Mayra C. C.; Vieira, J.; Abrunhosa, Luís; Martins, Joana T.; Alves, Thais F. R.; Tundisi, Louise L.; Ataide, Janaina A.; Costa, Juliana S. R.; Jozala, Angela F.; Nascimento, Laura O.; Mazzola, Priscila G.; Chaud, Marco V.; Vicente, António A.; Lopes, André M., Curcumin encapsulation in nanostructures for cancer therapy: a 10-year overview. International Journal of Pharmaceutics, 604(120534), 2021 03785173 10.1016/j.ijpharm.2021.120534 33781887 https://www.sciencedirect.com/science/article/pii/S0378517321003392 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Elsevier |
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Elsevier |
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