Study on solubility of pharmaceutical compounds in ionic liquids

Bibliographic Details
Main Author: Santos, Ana Rute Duarte dos
Publication Date: 2013
Format: Master thesis
Language: eng
Source: Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
Download full: http://hdl.handle.net/10362/9660
Summary: Dissertation to obtain the degree of master in Chemical and Biochemical Engineering
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spelling Study on solubility of pharmaceutical compounds in ionic liquidsSolubilitySolid–liquid equilibriumIonic liquidThermochemical propertiesPartition coefficientGreen chemistryDissertation to obtain the degree of master in Chemical and Biochemical EngineeringThe sufficient solubility of N-acetyl-L-cysteine (NAC), coumarin (COU) and 4-hydroxycoumarin (4HC) in alternative solvents obtained in this work can open new perspectives in pharmaceutical processing. Solid–liquid equilibrium (SLE) measurements have been made using a dynamic (synthetic) method. The melting point and the enthalpy of fusion of the pharmaceutical compounds were acquired using differential scanning calorimetry (DSC). The solubility of N-acetyl-L-cysteine and 4-hydroxycoumarin in trifluoromethanesulfonate ionic liquids was found to be significantly higher than in the studied bis(trifluoromethylsulfonyl)imide ionic liquids, and when compared, coumarin have the opposite behaviour. The best solvent amongst studied for this antioxidant (NAC) and anticoagulants (COU and 4HC) was discovered. The solid–liquid phase equilibrium were described using six different correlation equations which revealed relatively good description with the acceptable standard deviation temperature range. Moreover, the solubility data was used to calculate the 1-octanol/water partition coefficients and experimental partition coefficients (logP) was found to be negative in N-acetyl-L-cysteine and positive in the case of coumarin, at five temperatures with N-acetyl-L-cysteine being more hydrophilic and coumarin more hydrophobic; These results are also proof of the possibility of using these compounds as pharmaceutical products.Faculdade de Ciências e TecnologiaBogel-Łukasik, EwaRUNSantos, Ana Rute Duarte dos2013-05-20T11:08:19Z20132013-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/masterThesisapplication/pdfhttp://hdl.handle.net/10362/9660enginfo:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2024-03-11T03:42:56Zoai:run.unl.pt:10362/9660Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-20T03:18:58.232708Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse
dc.title.none.fl_str_mv Study on solubility of pharmaceutical compounds in ionic liquids
title Study on solubility of pharmaceutical compounds in ionic liquids
spellingShingle Study on solubility of pharmaceutical compounds in ionic liquids
Santos, Ana Rute Duarte dos
Solubility
Solid–liquid equilibrium
Ionic liquid
Thermochemical properties
Partition coefficient
Green chemistry
title_short Study on solubility of pharmaceutical compounds in ionic liquids
title_full Study on solubility of pharmaceutical compounds in ionic liquids
title_fullStr Study on solubility of pharmaceutical compounds in ionic liquids
title_full_unstemmed Study on solubility of pharmaceutical compounds in ionic liquids
title_sort Study on solubility of pharmaceutical compounds in ionic liquids
author Santos, Ana Rute Duarte dos
author_facet Santos, Ana Rute Duarte dos
author_role author
dc.contributor.none.fl_str_mv Bogel-Łukasik, Ewa
RUN
dc.contributor.author.fl_str_mv Santos, Ana Rute Duarte dos
dc.subject.por.fl_str_mv Solubility
Solid–liquid equilibrium
Ionic liquid
Thermochemical properties
Partition coefficient
Green chemistry
topic Solubility
Solid–liquid equilibrium
Ionic liquid
Thermochemical properties
Partition coefficient
Green chemistry
description Dissertation to obtain the degree of master in Chemical and Biochemical Engineering
publishDate 2013
dc.date.none.fl_str_mv 2013-05-20T11:08:19Z
2013
2013-01-01T00:00:00Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/masterThesis
format masterThesis
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://hdl.handle.net/10362/9660
url http://hdl.handle.net/10362/9660
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
publisher.none.fl_str_mv Faculdade de Ciências e Tecnologia
dc.source.none.fl_str_mv reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron:RCAAP
instname_str Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
instacron_str RCAAP
institution RCAAP
reponame_str Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
collection Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)
repository.name.fl_str_mv Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação
repository.mail.fl_str_mv
_version_ 1799137833931243520

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