Five layers of receptor signaling in γδ T-Cell differentiation and activation
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2015 |
| Outros Autores: | , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
| Texto Completo: | http://hdl.handle.net/10451/49022 |
Resumo: | Copyright: © 2015 Ribeiro, Ribot and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
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Five layers of receptor signaling in γδ T-Cell differentiation and activationT-cell costimulationT-cell receptorCytokinesNatural killer receptorsγδ T-cellsCopyright: © 2015 Ribeiro, Ribot and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.The contributions of γδ T-cells to immunity to infection or tumors critically depend on their activation and differentiation into effectors capable of secreting cytokines and killing infected or transformed cells. These processes are molecularly controlled by surface receptors that capture key extracellular cues and convey downstream intracellular signals that regulate γδ T-cell physiology. The understanding of how environmental signals are integrated by γδ T-cells is critical for their manipulation in clinical settings. Here, we discuss how different classes of surface receptors impact on human and murine γδ T-cell differentiation, activation, and expansion. In particular, we review the role of five receptor types: the T-cell receptor (TCR), costimulatory receptors, cytokine receptors, NK receptors, and inhibitory receptors. Some of the key players are the costimulatory receptors CD27 and CD28, which differentially impact on pro-inflammatory subsets of γδ T-cells; the cytokine receptors IL-2R, IL-7R, and IL-15R, which drive functional differentiation and expansion of γδ T-cells; the NK receptor NKG2D and its contribution to γδ T-cell cytotoxicity; and the inhibitory receptors PD-1 and BTLA that control γδ T-cell homeostasis. We discuss these and other receptors in the context of a five-step model of receptor signaling in γδ T-cell differentiation and activation, and discuss its implications for the manipulation of γδ T-cells in immunotherapy.Our work is supported by Fundação para a Ciência e Tecnologia (SFRH/BD/84123/2012 to Sérgio T. Ribeiro; SFRH/BPD/78135/2011 and EXPL/IMI-IMU/0170/2013 to Julie C. Ribot) and European Research Council (StG_260352 to Bruno Silva-Santos).FrontiersRepositório da Universidade de LisboaRibeiro, Sérgio TRibot, JulieSilva-Santos, Bruno2021-07-20T11:04:40Z20152015-01-01T00:00:00Zinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10451/49022engFront Immunol. 2015 Jan 26;6:1510.3389/fimmu.2015.000151664-3224info:eu-repo/semantics/openAccessreponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos)instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãoinstacron:RCAAP2023-11-08T16:52:14Zoai:repositorio.ul.pt:10451/49022Portal AgregadorONGhttps://www.rcaap.pt/oai/openaireopendoar:71602024-03-19T22:00:33.558702Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informaçãofalse |
| dc.title.none.fl_str_mv |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| title |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| spellingShingle |
Five layers of receptor signaling in γδ T-Cell differentiation and activation Ribeiro, Sérgio T T-cell costimulation T-cell receptor Cytokines Natural killer receptors γδ T-cells |
| title_short |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| title_full |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| title_fullStr |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| title_full_unstemmed |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| title_sort |
Five layers of receptor signaling in γδ T-Cell differentiation and activation |
| author |
Ribeiro, Sérgio T |
| author_facet |
Ribeiro, Sérgio T Ribot, Julie Silva-Santos, Bruno |
| author_role |
author |
| author2 |
Ribot, Julie Silva-Santos, Bruno |
| author2_role |
author author |
| dc.contributor.none.fl_str_mv |
Repositório da Universidade de Lisboa |
| dc.contributor.author.fl_str_mv |
Ribeiro, Sérgio T Ribot, Julie Silva-Santos, Bruno |
| dc.subject.por.fl_str_mv |
T-cell costimulation T-cell receptor Cytokines Natural killer receptors γδ T-cells |
| topic |
T-cell costimulation T-cell receptor Cytokines Natural killer receptors γδ T-cells |
| description |
Copyright: © 2015 Ribeiro, Ribot and Silva-Santos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
| publishDate |
2015 |
| dc.date.none.fl_str_mv |
2015 2015-01-01T00:00:00Z 2021-07-20T11:04:40Z |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10451/49022 |
| url |
http://hdl.handle.net/10451/49022 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Front Immunol. 2015 Jan 26;6:15 10.3389/fimmu.2015.00015 1664-3224 |
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info:eu-repo/semantics/openAccess |
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openAccess |
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application/pdf |
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Frontiers |
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Frontiers |
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reponame:Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) instname:Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação instacron:RCAAP |
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Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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RCAAP |
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RCAAP |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) |
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Repositório Científico de Acesso Aberto de Portugal (Repositórios Cientìficos) - Agência para a Sociedade do Conhecimento (UMIC) - FCT - Sociedade da Informação |
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