Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage

Detalhes bibliográficos
Autor(a) principal: Almeida, M. C. de
Data de Publicação: 2003
Outros Autores: Cardoso, S. A., Barral-Netto, Manoel
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFBA
Texto Completo: http://repositorio.ufba.br/ri/handle/ri/16535
Resumo: Texto completo: acesso restrito. p. 153–162
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spelling Almeida, M. C. deCardoso, S. A.Barral-Netto, ManoelAlmeida, M. C. deCardoso, S. A.Barral-Netto, Manoel2014-11-11T16:00:14Z20030020-7519http://repositorio.ufba.br/ri/handle/ri/16535v. 33, n. 2Texto completo: acesso restrito. p. 153–162The initial steps of Leishmania infection in humans are largely unknown. There is limited information on the Leishmania infected human monocytes, the first cells that the parasite lives in, particularly related to costimulatory molecules. We show here that Leishmania (L.) chagasi infection avoids inducing proinflammatory molecules and has striking down modulating effects on human monocytes or macrophages. It does not induce CD54, interleukin (IL)-12 or tumour necrosis factor-α, potent proinflammatory cytokines and down modulates CD11b expression in monocytes. Lipopolysaccharide stimulated IL-12 (p40) levels, CD54 and HLA-DR expression are diminished in infected monocytes as well as interferon-γ stimulated HLA-DR and HLA-ABC expression in infected macrophages. There is a negative correlation between CD54 and CD86 expression in both monocytes and macrophages. The depressed expression of class I and II molecules, absence of key proinflammatory cytokines and impaired expression of costimulatory molecules induced by L. chagasi could leave the immune system, at least in its initial phases in anergy or ignorance.Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-01-14T14:13:43Z No. of bitstreams: 1 M.C. De Almeida.pdf: 428562 bytes, checksum: 5eaf85863df4c9eefab0050e225818fc (MD5)Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-11-11T16:00:14Z (GMT) No. of bitstreams: 1 M.C. 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dc.title.pt_BR.fl_str_mv Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
dc.title.alternative.pt_BR.fl_str_mv International Journal for Parasitology
title Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
spellingShingle Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
Almeida, M. C. de
Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
title_short Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
title_full Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
title_fullStr Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
title_full_unstemmed Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
title_sort Leishmania (Leishmania) chagasi infection alters the expression of cell adhesion and costimulatory molecules on human monocyte and macrophage
author Almeida, M. C. de
author_facet Almeida, M. C. de
Cardoso, S. A.
Barral-Netto, Manoel
author_role author
author2 Cardoso, S. A.
Barral-Netto, Manoel
author2_role author
author
dc.contributor.author.fl_str_mv Almeida, M. C. de
Cardoso, S. A.
Barral-Netto, Manoel
Almeida, M. C. de
Cardoso, S. A.
Barral-Netto, Manoel
dc.subject.por.fl_str_mv Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
topic Costimulation
CD54
CD11b
CD86
Cytokines
Leishmania
description Texto completo: acesso restrito. p. 153–162
publishDate 2003
dc.date.issued.fl_str_mv 2003
dc.date.accessioned.fl_str_mv 2014-11-11T16:00:14Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://repositorio.ufba.br/ri/handle/ri/16535
dc.identifier.issn.none.fl_str_mv 0020-7519
dc.identifier.number.pt_BR.fl_str_mv v. 33, n. 2
identifier_str_mv 0020-7519
v. 33, n. 2
url http://repositorio.ufba.br/ri/handle/ri/16535
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.source.pt_BR.fl_str_mv http://dx.doi.org.ez10.periodicos.capes.gov.br/10.1016/S0020-7519(02)00266-7
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFBA
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reponame_str Repositório Institucional da UFBA
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